Serial craniectomies for intracranial infection 5.5 millennia ago

A skull found in a burial cave near Jericho with evidence of craniectomies dating approximately 5500 years ago had signs of frontal sinusitis and intracranial infection. The location of the three craniotomies in the frontal bone of this skull and evidence of the infection bursting from the sinus intracranially suggest that this is the oldest known cranial surgery performed due to symptoms of a medical aetiology : epidural infection.