文物防霉剂华科—108的合成及应用研究

为研制一种适用于恶劣环境现场的物防霉剂，以N，N-二正辛基-3，3-二硫代二丙酰胺在溶剂中通氯气，环化制得2-正辛基-4-异噻唑啉-3-酮盐酸盐，经水解分离油相配以载体即得防霉剂华科-108。通过试验得到了最佳的反应条件(反应温度15．4-2℃，胺化物：氯气(摩尔比)=1：3．75，通气时间2h，搅拌时间1h，确立了可行有效的分析方法，收率可达70％。它在汉阳陵考古发掘现场应用中表现出明显的抑菌、杀菌、防霉效果和优良的适应性，可为类似情况的处理提供有益的借鉴。

The synthesis and use of cultural relics fungicide Huake-108

In order to prepare a funficide used for antiquities protection bad surroundings,N,Ndioctyl3,3dithiodpropinamide is halogenated and cyclized with such reactants as chlorine to acrude reaction mixture containing 2noctyl4lisothiazolone hydrohalide salt in solution. The hydrohalide salt is crystallized isolated and then hydrolyzed with water to the desired isothiazolone(70% yield). The Huake108 is achieved when the isothiazolone is mixed with a special solution. The best production condition is obtained from the experiments and the useful analytic method is derived. When it is used at the excavation spot of the Yangling Mausoleum,the Huake108 has excellent fungicide effect and good adaptability can be see. It can provide benifical results for the similar conditions.