George III: a revised view of the royal malady |
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Authors: | Brownstein S |
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Affiliation: | Harlem Hospital Center, New York, 10037, USA. |
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Abstract: | George III of England's episodic psychotic illness is described. The data has previously been used to substantiate the diagnosis of an unlikely hereditary metabolic disease, porphyria. A scientific perspective, aimed at removing psychiatric diagnosis from dependence on subjective evaluations, is corrected by the diagnosis of a mood disorder. His unipolar mania of late onset is a syndrome, the sine qua non of bipolar disorder, in this instance complicated by the toxicity of quinine, antimony, and purgatives. |
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