Tuberculosis among Iron Age individuals from Tyva,South Siberia: palaeopathological and biomolecular findings |
| |
| Authors: | E.M. Murphy Y.K. Chistov R. Hopkins P. Rutland G.M. Taylor |
| |
| Affiliation: | 1. School of Geography, Archaeology and Palaeoecology, Queen''s University Belfast, Belfast BT7 1NN, Northern Ireland, UK;2. Peter the Great Museum of Anthropology and Ethnography (Kunstkamera), 3 University Embankment, St. Petersburg 199034, Russia;3. Centre for Molecular Microbiology and Infectious Disease, Imperial College of Science, Technology, and Medicine, South Kensington Campus, London SW7 2AZ, England, UK;4. Department of Genetics, Institute of Child Health, University College London, London WC1N 1EH, England, UK;5. Department of Infectious Diseases and International Health, Windeyer Institute, University College London, 46 Cleveland Street, London W1T 4JF, England, UK |
| |
| Abstract: | The study focuses on the evidence for tuberculosis apparent in an Iron Age population recovered from the cemetery of Aymyrlyg, Tyva (Tuva), South Siberia. A recent wholly molecular study of five of the cases confirmed the presence of Mycobacterium tuberculosis (MTB) complex DNA in four of the individuals. In all cases the disease was caused by strains of Mycobacterium bovis rather than Mycobacterium tuberculosis and represents the first positive identification of the bovine form of the disease in archaeological human remains. Details of the palaeopathological characteristics of the cases are provided in the current paper, while the molecular observations are extended to include a quantitative evaluation of the surviving mycobacterial DNA using real-time PCR. The observation that bovine tuberculosis was the pathogen responsible is discussed in terms of current understanding of the evolution of the MTB complex as well as the implications for future ancient DNA studies in this area. |
| |
| Keywords: | Ancient DNA Palaeopathology Aymyrlyg Siberia Iron Age Mycobacterium bovis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
