Further developments in molecular sex assignment: a blind test of 18th and 19th century human skeletons |
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Authors: | Evangelia Daskalaki Cecilia Anderung Louise Humphrey Anders Götherström |
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Institution: | 1. Department of Ecology and Genetics, Evolutionary Biology, Uppsala University, Norbyvägen 18D, S-752 36 Uppsala, Sweden;2. Palaeontology Department, Natural History Museum, Cromwell Road, SW7 5BD London, United Kingdom |
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Abstract: | The identification of sex in human remains recovered from archaeological locations is important in order to understand the social and biological structure of past societies, and to reconstruct past population demographic events. Sex determination is usually based on morphological traits of the skeletons, with the drawback that most methods do not apply to juveniles and require well preserved remains. In cases where morphological methods cannot be used, or are ambiguous, methods of molecular sexing systems are an alternative. In this methodological study we tested and validated the accuracy and usefulness of a molecular sexing method based on the amelogenin gene using pyrosequencing. We did this in a double blind study of documented 18th and 19th century human remains. |
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Keywords: | Molecular sexing Human Ancient DNA Pyrosequencing |
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