Bone remodelling following a lower leg fracture in the 11,000‐year‐old hunter‐gatherer from Vado all' Arancio (Italy)

The Upper Palaeolithic skeleton from Vado all'Arancio (Italy), dated to about 11,330 BP, exhibits a severe ankle fracture healed with residual deformation. Following recovery, this young hunter‐gatherer continued to walk for an extended period of time, albeit in a mechanically altered manner. While right‐left differences in external lower limb bone measurements are relatively low, biomechanical analysis of femur and tibia indicates unusually pronounced asymmetry in all cross‐sectional measures of diaphyseal strength. Asymmetry results primarily from normal side endosteal hypertrophy, and not from hypotrophy of the injured limb, suggesting that this individual resumed active life following recovery. This pattern of asymmetry underscores the role of physical activity in maintaining bone mass. Copyright © 2002 John Wiley & Sons, Ltd.     

Compensatory bone remodelling in moose: a study of age,sex, and cross‐sectional cortical bone dimensions in moose at Isle Royale National Park

We studied interrelationships among age, sex, and cross‐sectional cortical bone dimensions using quantitative computed tomography (QCT) scans of metatarsal bones of 180 moose (Alces alces) that died in Isle Royale National Park, Michigan. As a large‐bodied quadruped with demanding ecological constraints on movement and behaviour, a moose experiences different weight‐bearing and mechanical stressors than humans, to whom most existing studies of mechanical adaptations of bone pertain. In moose, both sexes showed significant subperiosteal expansion and an increase in medullary area, with an overall increase in cortical bone area over time. Female moose did not exhibit cortical thinning or reduction in cross‐sectional area with age, rather they showed an increase in cortical bone area with periosteal apposition exceeding endosteal resorption, similar to the males. We also found that moose undergo changes in bone geometry through remodelling of bone similar to humans, suggesting a compensatory mechanism for increasing bone strength under conditions of decline in bone mineral density with age. Copyright © 2002 John Wiley & Sons, Ltd.     

Effects of a nineteenth century below-knee amputation and prosthesis on femoral morphology

Access to the lower limbs from a historically-identified nineteenth century below-knee amputee who had worn a hardwood ectoprosthesis for an extended time prior to death provides a natural experiment for investigating the morphological and histological effects of the resulting altered mechanical environment. Osteometry (measuring total bone size), cross-sectional geometry (bending and axial rigidity) and histology (bone turnover rate) are assessed. A reduction in size and geometric strength, along with an increase in cortical bone turnover, indicate that the midshaft and distal regions from the affected femur were partially shielded from functional strain. Structural compliance of the prosthesis, probably originating from design and material of manufacture, to some degree preserved the mechanical and morphological integrity of the proximal subtrochanteric region. The results of this case study are consistent with contemporary theory in skeletal biomechanics, for example, Frost's Mechanostat, which suggests that insufficient functional strain promotes intracortical remodelling and endosteal expansion.     

Reflections on Modelling Across the Arts and Sciences

Abstract

Relying on modelling protocols and examples of cross-border models, it is argued that an increasingly deliberate, self-aware use of modelling enhances constructive interactions from the arts to the sciences. Models are tailored from materials used in their environments of application in order to enable the performance of desired tasks, e.g. metaphorical constructions in poetry. They are suited for interdisciplinary interactions when their domain of application is allowed to extend beyond traditional disciplinary boundaries.