Thalassaemia: Its diagnosis and interpretation in past skeletal populations

The diagnosis of thalassaemia in archaeological populations has long been hindered by a lack of pathogonomic features, and the non‐specific nature of cribra orbitalia and porotic hyperostosis. In fact, clinical research has highlighted more specific diagnostic criteria for thalassaemia major and intermedia based on changes to the thorax (‘rib‐within‐a‐rib’ and costal osteomas). A recent re‐examination of 364 child skeletons from Romano‐British Poundbury Camp, Dorset revealed children with general ‘wasting’ of the bones and three children who demonstrated a variety of severe lesions (e.g. zygomatic bone and rib hypertrophy, porotic hyperostosis, rib lesions, osteopenia and pitted diaphyseal shafts) that are inconsistent with dietary deficiency alone, and more consistent with a diagnosis of genetic anaemia. Two of these children displayed rib lesions typical of those seen in modern cases of thalassaemia. The children of Poundbury Camp represent the first cases of genetic anaemia identified in a British archaeological population. As thalassaemia is a condition strongly linked to Mediterranean communities, the presence of this condition in a child from England, found within a mausoleum, suggests that they were born to wealthy immigrant parents living in this small Roman settlement in Dorset. This paper explores the diagnostic criteria for genetic anaemia in the archaeological literature and what its presence in ancient populations can contribute to our knowledge of past human migration. Copyright © 2010 John Wiley & Sons, Ltd.     

Age changes in bone microstructure: do they occur uniformly?

Age estimations based on conventional multifactorial methods were compared with trends observed in the internal morphology of bones obtained from high‐resolution µCT. Specifically, average trabecular thickness and number of trabeculae/mm transect were determined in the non‐load‐bearing capitate (hand) and the load‐bearing navicular (foot). The µCT findings reveal age‐related trends but—surprisingly—these correspond only loosely with the ages assigned by conventional ageing methods, and are also not in accordance with what would be predicted from biomechanical considerations: trabeculae tend to be thinner in the (habitually) load‐bearing navicular than in the (habitually) non‐load‐bearing capitate. While the statistically significant correlation between trabecular thickness and number of trabeculae would suggest a compensatory mechanism between these two aspects of microanatomy, they are not correlated with the assigned ages and, importantly, may differ between sexes. Only in females is there an unequivocal trend towards trabecular thickness increase with age. These findings, although unexpected, can be reconciled with recent histological evidence and assumed average activity levels in historical populations. Conversely, changes in trabecular number are less clear‐cut and may be due to the lack of very old individuals in the sample. Nevertheless, the trends observed for trabecular thickness, as well as for trabecular number, seem to imply that the higher incidence of osteoporosis in women could be explained from a structural point of view alone. Copyright © 2005 John Wiley & Sons, Ltd.     

Cortical bone dynamics and age‐related osteopenia in a Longobard archaeological sample from three graveyards of the Veneto region (northeast Italy)

Since the contribution of Brothwell and co‐workers in early 1968, few studies have considered the cortical bone involution in European skeletal series of archaeological interest. The present study concerns the involutive process mechanisms and intra‐ and inter‐sexual variability in femurs of 66 adults belonging to three graveyards of the Longobard era excavated in the Vicenza province (northeast Italy). Cortical thickness and cortical and medullary areas were measured and a correlation matrix was generated for each sex and age class. Intra‐ and inter‐sexual variability were evaluated by two‐tailed t‐tests and a sexual dimorphism index. The results indicate a considerable difference between the sexes, with females showing an earlier and more marked cortical bone loss, as expected. Moreover, comparing the data with the scarce literature available, some discrepancies in cortical bone involution were found in populations with different patterns of adaptation, suggesting the need for further studies in this direction aimed at understanding bone environment dynamics. Copyright © 2000 John Wiley & Sons, Ltd.