Emigrated neuroscientists from Berlin to North America

ABSTRACT

The highest number of German scholars and physicians, forced by the National Socialist regime to emigrate for “race” or political reasons, were from Berlin. Language and medical exams were requested differently in their new host country—the United States—leading to a concentration of immigrants in the New York and Boston areas. Very early Emergency Committees in Aid of German Scholars and Physicians were established. Undergraduate students (like F. A. Freyhan, H. Lehmann, and H.-L. Teuber) from Berlin seemed to integrate easily, in contrast to colleagues of more advanced age. Some of the former chiefs and senior assistants of Berlin’s neurological departments could achieve a successful resettlement (C. E. Benda, E. Haase, C. F. List, and F. Quadfasel) and some a minor degree of success (F. H. Lewy and K. Goldstein). A group of neuropsychiatrists from Bonhoeffer’s staff at the Berlin Charité Hospital could rely on the forceful intercession of their former chief. The impact of the émigré colleagues on North American neuroscience is traced in some cases. Apart from the influential field of psychoanalysis, a more diffuse infiltration of German and European neuropsychiatry may be assumed. The contribution to the postwar blossoming of neuropsychology by the émigré neuroscientists K. Goldstein, F. Quadfasel, and H.-L. Teuber is demonstrated in this article.     

Making Distinctions: The Contribution of Hector Landouzy to Differential Diagnosis in Relation to Hysteria and Epilepsy

Hector Landouzy (1818-1864) is known for his Traité Complet de l'Hystérie (1846), which was crowned by the Académie de Médecine, but this work is not given much importance in historical accounts. It deserves more attention because it was more than an orthodox statement about the nature of hysteria. In the context of the diagnostic confusion between epilepsy and hysteria, it introduced a method of presenting criteria to facilitate diagnosis. An examination of French authors on epilepsy and hysteria in the second half of the nineteenth century suggests that this method probably set the example which was to be followed by later clinicians, including Charcot at the Salpêtrière.     

Diffusion of Electrical Current in the Experiments of Fritsch and Hitzig and Ferrier Failed to Negate Their Conclusion of the Existence of Cerebral Motor Centers

This paper explores the implications of an early criticism of the stimulation studies of Fritsch and Hitzig and Ferrier for localized brain functions. Fritsch and Hitzig and Ferrier concluded that motor centers reside in the cortices of the hemispheres. Their studies were replicated, but their conclusions were not generally accepted initially. The most salient, laboratory-based criticism was that the electrical current used for stimulation diffused well beyond the cortex making their conclusion of cerebral motor centers unacceptable. The diffusion argument was essentially a French suggestion. Ferrier's and American research and interpretations provided data and arguments against it.     

Georg Friedrich Handel's strokes*

Abstract

Although there is no definite proof, it seems most likely that Georg Friedrich Handel suffered from cere‐brovascular disease, which caused two or three minor strokes and weakness of his eyesight in his last years. His etiologically important risk factors and the symptoms of Handel's strokes are presented and evaluated by primary sources; various diagnoses are discussed. In Handel's musical work, no direct impact from his illness can be found, but there are some indirect outflows of Handel's pathography on his compositions, especially the Messiah.     

Did Herbert Spencer Have Reading Epilepsy?

Herbert Spencer, the nineteenth-century philosopher, has frequently been dismissed as a “fantastical hypochondriac” (as his most recent biographer, Mark Francis, terms him). Yet he left a record in his Autobiography of symptoms that suggest a very different diagnosis. Abruptly at age 35, he found that the activity of reading, previously indulged in without difficulty, triggered paroxysmal episodes of disturbing “head-sensations” including “giddiness” (so Spencer described them); these severely curtailed his ability to carry out his philosophical studies. Of all possible explanations for such episodes, none seems as likely as reading epilepsy. Enduring preconceptions about Spencer's presumed neurosesmay have kept modern historians from appreciating that Spencer suffered from a legitimate, if esoteric, neurological malady.     

An American Controversy about the Localization of Cutaneous Sensory Regions and their Relation to Motor Regions

Three American neurologists (C. K. Mills, C. L. Dana, and M. A. Starr) explored the anatomical limits of the motor and tactile systems in the brain from 1884 to 1895. Their papers and critiques of one another show contemporary knowledge, limits of their thinking, and difficulties deciding between alternatives. The issue for them was whether there were separate sensory and motor regions or whether there was a combined sensory-motor region. They based their localization arguments on clinical and laboratory findings and on the conclusions of H. Munk and D. Ferrier. There is a discussion about why differences were unresolved.     

“History had taken such a large piece out of my life” — Neuroscientist refugees from Hamburg during National Socialism

ABSTRACT

Approximately 9,000 physicians were uprooted for so-called “racial” or “political” reasons by the Nazi regime and 6,000 fled Germany. These refugees are often seen as survivors who contributed to a “brain drain” from Germany. About 432 doctors (all specialties, private and academic) were dismissed from the major German city of Hamburg. Of these, 16 were Hamburg University faculty members dismissed from their government-supported positions for “racial” reasons, and, of these, five were neuroscientists. In a critical analysis, not comprehensively done previously, we will demonstrate that the brain drain did not equal a “brain gain.” The annihilation of these five neuroscientists’ careers under different but similar auspices, their shameful harassment and incarceration, financial expropriation by Nazi ransom techniques, forced migration, and roadblocks once reaching destination countries stalled and set back any hopes of research and quickly continuing once-promising careers. A major continuing challenge is finding ways to repair an open wound and obvious vacuum in the German neuroscience community created by the largely collective persecution of colleagues 80 years ago.     

Next Emperor,Please! No End to Retrospective Diagnostics

Abstract

The beginning of the seventeenth century marked the start of a scientific revolution, which had consequences for medicine. Vesalius in anatomy, and Harvey in physiology, were important figures who gave the Hippocratic and Galenic traditions new impulses. In this period of change in medical thought, Nicolaas Tulp (1593–1674) wrote his ‘Observationes Medicae’ (Tulp, 1641). A controversy existed in The Netherlands, concerning the circulation, with many doctors still adhering to the Galenic tradition. The following analysis discusses some of the neurologic cases from Tulp's book, seen in the light of modern medical thought.     

Hallucinations and Pathological Visual Perceptions in Maupassant's Fantastical Short Stories- A Neurological Approach

Maupassant excelled as a realist writer of the nineteenth century, with fantastical short stories being an outstanding example of his literary genius. We have analysed four of his fantastical stories from a neurological point of view. In “Le Horla,” his masterpiece, we have found nightmares, sleep paralysis, a hemianopic pattern of loss and recovery of vision, and palinopsia. In “Qui sait” and in “La main” there is also an illusory movement of the objects in the visual field, although in a dreamlike complex pattern. In “Lui,” autoscopy and hypnagogic hallucinations emerge as fantastical key elements.

The writer suffered from severe migraine and neurosyphilis involving the optic nerve, which led to his death by general paralysis of the insane (GPI). Visual loss and visual hallucinations affected the author in his last years, before a delirant state confined him to a nursing home. Our original hypothesis, which stated that he could have translated his sensorial experiences coming from this source to his works, had to be revised by analyzing some of his earliest works, notably “Le Docteur Héraclius Gloss” and “La main d’écorché” (1875). We found hallucinatory symptoms, adopting the form of autoscopy and other elaborated visual misperceptions, in stories written at age 25, when Maupassant was allegedly healthy. Therefore, we hypothesize that they may be related to his hypersensitive disposition, assuming that no pathology is necessary to experience such vivid experiences. In addition, Maupassant's abuse of drugs, as illustrated in “Rêves,” could have provided an additional element to outline his painstaking visual depictions. All these factors, in addition to his up-to-date neurological knowledge and attendance at Charcot's lectures at “La Salpêtrière,” armed the author for repetitive and enriched hallucinatory experiences, which were transferred relentlessly into his works from the beginning of his career.