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This paper traces responses to house flies in US cities as health departments attempted to control pollution and disease in the early twentieth century. It speaks to other historical geographies about the state, citizens, and the urban environment by showing how medical entomology prescribed contradictory changes to civic and domestic space, and how urban people and nature resisted these changes. With the advent of medical entomology, health reformers came to see house flies as agents that wove the entire city together as an interconnected ecology, carrying diseases from neighborhood to neighborhood and across the threshold of the home. But different reformers argued for quite distinct exercises of power in the urban landscape and ecological processes. Some physicians and entomologists argued that the state must modernize networks of fly-breeding organic matter, most notably horse manure and human waste. Such interventions were intended to be preventive and holistic, and aimed to protect all city dwellers. Other reformers, however, doubted the capacity of the state to tame material flows of waste, and instead sought changes to domestic space that would require householders – especially women – to shore up the boundaries of the house against flies. When city governments adopted these distinct interventions they encountered quite distinct sorts of resistance because of the house fly's tight links with urban nature and domestic practices.  相似文献   
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