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Abstract

Since the 1990s, young people’s drinking has been a matter of public concern, attracting considerable media attention that has contributed to spreading the alarm. The purpose of this article is to dispel some stereotypes about youth drinking in Italy, by putting it in an international perspective and explaining some of the key factors that have contributed so far to limiting the spread of at-risk alcohol consumption when compared to other countries. Among these factors, the persistence of social values that emphasize family ties and the sharing of informal norms between adults and young people seem to play a prominent role. However, both the spread of increasingly individualistic values at a global level, and the growing complexity of transitions to adulthood could lead to changes in consumption patterns among Italian youth in the near future and increase risky behaviours.  相似文献   
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ABSTRACT In a recent study, Holmes and Stevens (2002) identify for the first time the positive relationship that exists between establishment scale and local industry concentration using a large cross‐sectional plant‐level data set for the United States. Using an exhaustive plant‐level panel data set for Irish manufacturing covering nearly three decades, we are able to extend their analysis in two ways. First, we show that failing to control for fixed effects biases the relationship upward, although the essence of the result still remains after fixed effects are included. Second, the link is substantially weaker when plants locate for the first time in an area, but strengthens with age for those that survive in the long run. We link our results to recent contributions on the dynamics of geographic concentration.  相似文献   
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Ancient preserved molecules offer the opportunity of gaining a deeper knowledge on their biological past. However, the development of a proteomic workflow remains a challenge. The analysis of fossils must involve a low quantity of material to avoid damaging the samples. In this study an enhanced proteomic protocol was applied to 5-milligram samples of about 130,000-year-old mammalian bones ranging from the end of the Middle Pleistocene up to the earlier Upper Pleistocene, excavated from Scladina Cave (Sclayn, Belgium). Using sequence homology with modern sequences, a biological classification was successfully achieved and the associated taxonomic ranks to each bone were identified consistently with the information gained from osteomorphological studies and palaeoenvironmental and palaeodietary data. Amino acid substitutions on collagens were identified, thus providing new information on extinct species sequences and helping in taxonomy-based clustering. Considering samples with no osteomorphological information, such as two fragments of bone retouchers, proteomics successfully identified the families providing paleontologists new information on these objects. Combining osteomorphology studies and amino acid variations identified by proteomics, one of the retouchers was potentially identified as belonging to the Ursus spelaeus species.  相似文献   
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In 2014, the Joint United Nations Programme on HIV/AIDS set the target of dramatically reducing the burden of HIV through expansion of access to timely HIV treatment. In order to achieve this target, it is necessary to expand access to care along the HIV cascade of care. This study examines the relationship between viral suppression and the availability of physicians providing HIV treatment in British Columbia, Canada. Data from the Drug Treatment Program of the British Columbia Centre for Excellence in HIV/AIDS was analyzed. The floating catchment method was used to assess physician availability and multivariable logistic regression was used to implement a confounder selection technique to independently assess the relationship between physician availability and viral load suppression. Individuals with more than 25 physicians within a one‐hour catchment were more likely to reside in urban areas and almost twice as likely to have a suppressed viral load (adjusted odds ratio: 1.97; 95% CI 1.50 – 2.58). This study highlights the impact of physicians’ availability on viral load levels. Mapping technology was used to identify the locations in which patients were most impacted by the lack of physicians.  相似文献   
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