Effects of Different Record Selection Methods on the Transverse Seismic Response of a Bridge in South Western British Columbia

The seismic response of a continuous 4-span bridge designed according to the current Canadian seismic provisions is investigated using Incremental Dynamic Analysis (IDA). Different earthquake types, including shallow crustal events, interface Cascadia subduction, and deep inslab subduction are considered. The median collapse capacities calculated using different record selection methods including Conditional Mean Spectrum (CMS)-based, Uniform Hazard Spectrum (UHS)-based, and epsilon-based methods are compared. The use of the epsilon-based method generally resulted in the highest collapse capacity predictions, but the CMS-based method was less sensitive to the number of records considered in the IDA.     

MESOGLIA & MICROGLIA – A Historical Review of the Concept of Mononuclear Phagocytes Within the Central Nervous System

More than a century and a half has elapsed since the first accounts of mesodermal phagocytic elements were proposed within the central nervous system. Over the intervening decades, body and substance were added to this concept through the advancement of histological techniques at the disposal of the researcher and the acute and keen-minded skills of the pathologist. Notable among these pioneering efforts were the contributions of W. Ford Robertson, Santiago Ramon y Cajal, Pio del Rio-Hortega and Wilder Penfield amongst an entire cavalcade of other noteworthy figures. The term ‘mesoglia’ and ‘third element of the nervous system’ was bestowed upon these cells towards the beginning of the twentieth century to account for their separate origins from neurons and macroglia. It was later amended by del Rio-Hortega in 1919, to ‘microglia’ in order to further discriminate between true mesodermal elements and oligodendrocytes, previously regarded as a component of ‘mesoglia’. This particular contention sparked much controversy among del Rio-Hortega’s peers and resulted in an escalation of fruitful research throughout Europe that eventually declined up to the outbreak of the Second World War. The post-war years were a period of the ‘dark ages’ that cast doubt on the very existence and nature of microglia, until the ‘renaissance’ of research was once again rejuvenated in the 1960s, by a new cohort of intrigued minds: Cammermeyer, Blinzinger, Kreutzberg and others who saw in the ‘third element’ the potential that is now commonly ascribed to microglia: the intrinsic immune effector cells of the CNS. It is now universally accepted that microglia are involved as the first line of rapid defence in any pathology of the nervous system, and as such, present a diagnostic tool for the neuropathologist. Although our knowledge of microglia stems from an extensive body of work conducted over the last two decades, much of the earlier work (pre-1960s) has remained somewhat obscure. This is partly accountable due to the limited availability of translated works, and additionally to the lack of a compendium of these articles. This paper will present a comprehensive overview of the pioneering research on mononuclear phagocytes within the central nervous system, which has direct bearing on our present-day understanding of the concept of microglia.     

Mesoglia & microglia--a historical review of the concept of mononuclear phagocytes within the central nervous system

More than a century and a half has elapsed since the first accounts of mesodermal phagocytic elements were proposed within the central nervous system. Over the intervening decades, body and substance were added to this concept through the advancement of histological techniques at the disposal of the researcher and the acute and keen-minded skills of the pathologist. Notable among these pioneering efforts were the contributions of W. Ford Robertson, Santiago Ramon y Cajal, Pio del Rio-Hortega and Wilder Penfield amongst an entire cavalcade of other noteworthy figures. The term 'mesoglia' and 'third element of the nervous system' was bestowed upon these cells towards the beginning of the twentieth century to account for their separate origins from neurons and macroglia. It was later amended by del Rio-Hortega in 1919, to 'microglia' in order to further discriminate between true mesodermal elements and oligodendrocytes, previously regarded as a component of 'mesoglia'. This particular contention sparked much controversy among del Rio-Hortega's peers and resulted in an escalation of fruitful research throughout Europe that eventually declined up to the outbreak of the Second World War. The post-war years were a period of the 'dark ages' that cast doubt on the very existence and nature of microglia, until the 'renaissance' of research was once again rejuvenated in the 1960s, by a new cohort of intrigued minds: Cammermeyer, Blinzinger, Kreutzberg and others who saw in the 'third element' the potential that is now commonly ascribed to microglia: the intrinsic immune effector cells of the CNS. It is now universally accepted that microglia are involved as the first line of rapid defence in any pathology of the nervous system, and as such, present a diagnostic tool for the neuropathologist. Although our knowledge of microglia stems from an extensive body of work conducted over the last two decades, much of the earlier work (pre-1960s) has remained somewhat obscure. This is partly accountable due to the limited availability of translated works, and additionally to the lack of a compendium of these articles. This paper will present a comprehensive overview of the pioneering research on mononuclear phagocytes within the central nervous system, which has direct bearing on our present-day understanding of the concept of microglia.     

Investigating cultural evolution through biological phylogenetic analyses of Turkmen textiles

The debate on the evolution of culture has focused on two processes in particular, phylogenesis and ethnogenesis. Recently, it has been suggested that the latter has probably always been more significant than the former. This proposal was assessed by applying cladistic methods of phylogenetic reconstruction to a data set comprising decorative characters from textiles produced by Turkmen tribes since the 18th century. The analyses focused on two periods in Turkmen history: the era in which most Turkmen practised nomadic pastoralism and were organised according to indigenous structures of affiliation and leadership; and the period following their defeat by Tsarist Russia in 1881, which is associated with the sedentarisation of nomadic Turkmen and their increasing dependence on the market. The results indicate that phylogenesis was the dominant process in the evolution of Turkmen carpet designs prior to the annexation of their territories, accounting for c.70% of the resemblances among the woven assemblages. The analyses also show that phylogenesis was the dominant process after 1881, although ethnogenesis accounted for an additional 10% of the resemblances among the assemblages. These results do not support the proposition that ethnogenesis has always been a more significant process in cultural evolution than phylogenesis.     

Seismic Response of Bridges Subjected to Different Earthquake Types Using IDA

Incremental Dynamic Analysis (IDA) was used to evaluate the seismic response of straight, continuous 4-span bridges with different sub-structure configurations. Three different record sets were chosen to represent three different earthquake types which can occur for a site such as Vancouver (i.e., crustal, subduction interface, and subduction inslab earthquakes). Seventy eight records were considered in each set (i.e., a total of 234 records) and the capacities of the bridges were evaluated using a fast IDA algorithm. A simplified method to account for the effects of spectral shapes was used. Different subsets of the records with specific characteristics were also used in the IDA. The bridges were designed and evaluated for two different design force modification factors and bridges with different degrees of irregularity were studied. Comparisons of the IDA results obtained indicated that in most of the cases the interface record sets resulted in lower median collapse capacities and hence were the most critical of the ground motions studied.