The commercialization of molecular biology: Walter Gilbert and the Biogen startup

Abstract

Recombinant DNA technology was invented in 1973. Within a few years, molecular biologists began developing practical applications and establishing private companies to exploit them commercially. In 1978, Harvard biologist Walter Gilbert, one of the leading figures in the field, joined the founding scientific advisory board of a Swiss biotech startup called Biogen. He later became the company’s CEO. His participation helped Biogen recruit top scientific talent in the United States and Europe and encouraged many of his professional colleagues to follow his example and go into business. In this way, Gilbert became a linchpin in the formation of the contemporary biotechnology industry. Because his adventures in business were shaped by circumstances unique to the late twentieth century, Gilbert’s case adds a distinctive point of reference to studies of academic entrepreneurship. It also points to internal contradictions and conceptual ambiguities in neo-institutional accounts of research privatization.     

The coastal landslides of Shetland

Little is known of hard-rock coastal landsliding in Scotland. We identify 128 individual coastal landslides or landslide complexes >50 m wide along the coasts of Shetland. Most are apparently translational slides characterized by headscarps, displaced blocks and/or debris runout, but 13 deep-seated failures with tension cracks up to 200 m inland from cliff crests were also identified. Thirty-one sites exhibit evidence of at least localized recent activity. Landslide distribution is primarily determined by the distribution of coastal cliffs >30 m high, and they are preferentially developed on metasedimentary rocks. Analysis of 16 landslides on Fetlar (NE Shetland) indicates that most are translational dip-slip failures; 3 represent deep-seated failures and several exhibit active frontal erosion attributable to basal sapping by storm waves. As these landslides terminate in shallow water, failure was probably initiated when rising sea level resulted in footslope erosion and upslope propagation of instability, causing downslope displacement of landslide blocks on upper slopes. ¹⁰Be exposure dating of two headscarps yielded ages of 4.8?±?0.2 ka and 4.4?±?0.2 ka, consistent with the onset of footslope erosion as sea level rose. Our results suggest that landslides have played a hitherto undocumented but important role in retreat of cliffed coastlines in Scotland.     

Die Verlegung der Berliner Sternwarte nach Babelsberg — ein konservativer Neubeginn

In 1913 the Berlin Observatory was moved from the center of the city to Babelsberg on the outskirts of Berlin, now part of Potsdam. The new observatory was considerably larger in size and with respect to its staff, and it had got a completely new equipment. At that time it was the most modern astronomical observatory in Germany and possibly even in Europe. However, the scientific results achieved afterward were not comparable to that of other institutions, especially in the USA. A main reason was the conservative concept for the observatory, drawn up by Wilhelm Foerster and his colleagues, and restricting the work to classical fields of astronomy. Foerster's successor Hermann Struve tried to follow rather strictly this concept as well as the traditions of his family of astronomers. This led to conflicts with his collaborators Eugen Goldstein, Erwin Finlay Freundlich and Paul Guthnick, who were interested rather in astrophysics than in the classical problems.     

The Newshot Island Boat Graveyard: an assemblage of 19th‐century vessels on the Clyde

A project by SCAPE, NAS, and local volunteers at Newshot Island on the Clyde near Glasgow has documented an important ships graveyard dating to the early 20th century. The vessels tell the story of the creation of the Clyde Navigation, represent a significant aspect of the river's history, and exemplify the technological and industrial development of the region. The survey and research revealed that the remains on site include the earliest diving support vessel known to have been recorded, and has resulted in the designation of the remains as a Scheduled Ancient Monument by Historic Environment Scotland.     

Space–Time Accessibility Under Conditions of Uncertain Travel Times: Theory and Numerical Simulations

Recently, several accessibility measures using the space–time prism concept have been suggested in the literature. These measures fail to take into account (i) the ability of individuals to adjust their activity–travel patterns in coping with constrained choice sets, (ii) uncertainty in the perception of travel times, (iii) temporal variability of travel times, and (iv) the influence of travel information on accessibility. The aim of the present article is to contribute to this literature by addressing these four shortcomings. Theory will be developed and illustrated using numerical simulations. The results suggest that the accessibility measure proposed in this article is a useful indicator of social inclusion in terms of the time individuals can spend to conduct their preferred activities. Moreover, accessibility is found to be affected by the presence of schedule delay penalties, restrictions in time allocation to activities, and the provision of travel time information in order to reduce uncertainty.     

Innovation in paper making: The Netherlands 1750–1850

Abstract

Until the middle of the eighteenth century Dutch paper makers had a leading position on the international paper market, both commercially and technically. From around 1700 a decline set in, which became dramatic after 1780. The introduction of new machinery and processes from Britain and elsewhere during the nineteenth century was slow, but when it came about, the Dutch paper industry regained an important part of the international market. This article attempts to explain the technological aspects of this development in the light of theories about the economic and technological history of the Netherlands in the eighteenth and nineteenth centuries.