Thalassemia: macroscopic and radiological study of a case

Differentiation of the genetic and the acquired anaemias, particularly in areas of the world where they may co‐exist, has been a challenge for palaeopathologists for over 100 years. In this paper we present macroscopic and radiographic skeletal lesions that are associated with the thalassemias in a 14‐year‐old girl from a modern reference collection of the University of Athens. This individual is of known sex, age, cause of death, place and dates of birth and death. The case is examined in terms of epidemiology, growth, distribution and severity of lesions and differential diagnosis. The entire skeleton is affected by marrow hyperplasia: lesions of the axial skeleton are extreme, and the appendicular skeleton is severely affected as well. The odontofacial manifestations that are diagnostic of thalassemia and differentiate it from other anaemias are present and include: maxillary and mandibular hyperplasia, reduced sinuses, displacement of maxillary dental structures, overbite, and generalised osteopenia. The development of extreme bone lesions and the ‘advanced’ age‐at‐death of this individual is explained as either the result of thalassemia major under a low transfusion regimen that was the norm during her lifetime, or to a form of thalassemia intermedia that allows survival to later life at the expense of gross skeletal alterations. The present status of skeletal studies in Greece does not support the identification of a genetic anaemia in past populations. The potential contribution of the current analysis in differentiating the anaemias in antiquity is evaluated. Copyright © 2006 John Wiley & Sons, Ltd.     

Patterns of the Future? British Mediterranean Strategy and the Choice Between Alexandria and Cyprus 1935–8

During the 1935–6 Abyssinian Crisis, the value of Malta as a British naval base came into question, as the island was vulnerable to Italian air attack. The British then examined the possibility of developing the Cypriot port of Famagusta as a naval base. However, by 1938 the project was rejected on the grounds of cost, while the 1936 Anglo-Egyptian Treaty gave London a more acceptable alternative, namely Alexandria, with its excellent port next to the Suez Canal. The examination of Cyprus’ possible role as a naval and air base and the evident strategic interrelation of the British positions in Egypt and in Cyprus in 1935–8 were indicative of future, post-war developments in British military thinking and strategic priorities.     

The Influence of Masonry Infill Walls in the Framework of the Performance-Based Design

In this article, a performance-based seismic design (PBD) methodology is proposed for the design of reinforced concrete buildings, taking into account the influence of infill walls. Two variants of the PBD framework are examined: The first is based on the non-linear static analysis procedure (NSP) while the second relies on the non-linear dynamic analysis procedure (NDP). Both design approaches are compared in the context of structural optimization with reference to the best possible design achieved for each case examined. Life-cycle cost analysis is considered a reliable tool for assessing the performance of structural systems and it is employed in this study for assessing the optimum designs obtained. The optimization part of the problem is performed with an Evolutionary Algorithm while three performance objectives are implemented in all formulations of the design procedures. The two most important findings can be summarized as follows: (i) if structural realization follows the design assumptions, then total expected life-cycle cost of the three type of structures, bare, fully infilled and open ground story, is almost the same and (ii) if an open ground story building is designed as bare or as fully infilled frame, real performance will be much worse than anticipated at the design stage.