The early history of the neuroscience of attention-deficit/hyperactivity disorder

Research on the neurobiology and pharmacotherapy of attention-deficit/hyperactivity disorder (ADHD) has grown exponentially since 1980. A reasonable question is whether this research has improved our understanding and treatment of ADHD. This article describes relevant developments that took place roughly between 1900 and 1970. During this time, the efficacy of stimulant therapy for the disorder was established and the symptoms of ADHD were linked to many possible nervous system disorders including in the brain-stem, reticular formation, diencephalon, basal ganglia, frontal lobes, and cortex. In 1970, the catecholamine hypothesis of ADHD was proposed. It is concluded that early theories about the neurobiologic basis of ADHD anticipated core ideas of modern theory.     

John Milton and the Beard-Hater: encounters with Julian the Apostate

ABSTRACT

This is a study of John Milton and Julian the Apostate, last of the pagan emperors. It follows two trajectories. The first takes as its subject Julian’s “School Edict” of 362 AD, which barred Christians from traditional classical education; while the second concerns a literary text by Julian himself, the Misopogon or “Beard-Hater,” in which he ironically attacked his own aversion to Antiochene Christianity, including the performance of plays. These discussions offer an opportunity to re-examine Milton’s comments on early Christian views of drama, as well as his own drafts for sacred dramas. All these discussions turn on the question of how the Christian is to approach pagan literature, one of the oldest intellectual debates within Christianity. I argue that Milton’s attitude to Greek literature as an entire process was shaped by his attitude to this specific debate, and that this can be seen afresh by viewing it through the eyes of its most powerful critic in antiquity, Julian the Apostate. I also furnish an account of the early-modern editorial tradition of Julian.     

Preservation potential of charcoal in alkaline environments: an experimental approach and implications for the archaeological record

Charcoalified plant material (usually wood) has been described as being inert with a high preservation potential. Although usually black on both the outside and inside, the physical and chemical properties differ as a function of temperature and time of exposure to a heat source. Post-depositional processes however may exert additional affects on charcoalified material and introduce bias into the archaeological record. This work explores the influence of alkaline conditions, often encountered in the soil environment, on the preservation potential of charcoalified material. Charcoal, experimentally produced at different temperatures, was exposed to a number of solutions of potassium hydroxide and calcium hydroxide with different pHs, to simulate exposure to alkaline soil conditions. Under these conditions chemically mediated physical interactions occur resulting in fragmentation of the charcoal samples into (very) small pieces the size of which depends upon the initial temperature of charcoalification. Moreover further interactions result in a decrease in reflectance relative to samples not exposed to alkaline conditions. Although experimentally driven the potential for physical loss of charcoal from a particular site coupled with the reduction in (expected) reflectance of any resident material, has important implications for any conclusions drawn regarding the archaeological record.     

Ghosts in the Garden: locative gameplay and historical interpretation from below#

The heritage industry now makes extensive use of digital audioguides and similar interpretation tools to reach new audiences but many remain rooted in authoritative and didactic conservatism. This paper critically evaluates the state of play in the field, from downloadable audio tours and apps, through more complex engagements with theatrically enhanced and affective simulation, to attempts at fuller dialogic visitor participation and the use of gps or RFID-triggered game mechanics. While ‘armchair’ and home screen-based game and interpretation models are addressed, particular attention is paid to the use of mobile and locative design, where embodiment in place is privileged over less associative or remote experience. The paper takes a research project led by the author as a case study. Ghosts in the Garden was conceived in collaboration with a museum and an experience design SME to test the potential of immersive, affective real world games on public understandings of history. It sought to engage visitors with researched history from below by using a pervasive media soundscape, the ‘ghosts’ of past visitors and a ‘choose-your-own-adventure’ game mechanic in which outcomes are variable, visitor agency is retained and a more radical model of historical knowledge suggested.     

The Early History of the Neuroscience of Attention-Deficit/Hyperactivity Disorder

Research on the neurobiology and pharmacotherapy of attention-deficit/hyperactivity disorder (ADHD) has grown exponentially since 1980. A reasonable question is whether this research has improved our understanding and treatment of ADHD. This article describes relevant developments that took place roughly between 1900 and 1970. During this time, the efficacy of stimulant therapy for the disorder was established and the symptoms of ADHD were linked to many possible nervous system disorders including in the brain-stem, reticular formation, diencephalon, basal ganglia, frontal lobes, and cortex. In 1970, the catecholamine hypothesis of ADHD was proposed. It is concluded that early theories about the neurobiologic basis of ADHD anticipated core ideas of modern theory.