Classic Studies on the Potential of Stem Cell Neuroregeneration

The 1990s and 2000s were the beginning of an exciting time period for developmental neuroscience and neural stem cell research. By better understanding brain plasticity and the birth of new neurons in the adult brain, contrary to established dogma, hope for therapy from devastating neurological diseases was generated. The potential for stem cells to provide functional recovery in humans remains to be further tested and to further move into the clinical trial realm. The future certainly has great promise on stem cells to assist in alleviation of difficult-to-treat neurologic disorders. This article reviews classic studies of the 1990s and 2000s that paved the way for the advances of today, which can in turn lead to tomorrow’s therapies.     

Conceptualizing Urban Inequalities as a Complex Socio-Technical Phenomenon

The United Nations World Social Report (2020) reveals that more than two thirds of the world's population live in countries where urban inequalities have increased in the last three decades. While urban inequalities are traditionally characterized as an economic issue, scholars are increasingly applying methods from geospatial analysis to study them. In the context of these advancements, it remains unclear what underlying perspectives are guiding decisions to concentrate on certain aspects of urban inequalities, while potentially ignoring others. We address this gap by reviewing the literature centered on the geospatial analysis of urban inequalities and identify three predominant research lenses from accessibility, distribution, and policy and stakeholder perspectives. As a primary contribution of this article, we connect the perspectives with ideas drawn from complexity theory to develop an overarching socio-technical framework for how urban inequalities emerge over space and time. While traditional scientific frameworks seek to increase knowledge through causality, complexity science acknowledges the inherent challenges in defining, understanding and solving complex problems such as urban inequalities, which has profound implications for their representation, modeling and interpretation. We critically reflect on the framework through key relational themes and insights drawn from the literature and close with considerations for future research.     

The Effects of Localization on Economic Performance: Analysis of Spanish Tourism Clusters

The sun, sea and sand model that has characterized the Spanish tourism sector and has caused Spain's tourist sector to become a world-class industry is actually undergoing drastic changes. This model is based on the existence of major tourism destinations characterized by high levels of industry specialisation, which makes them a target of analysis as tourism clusters in which the geographic concentration of synergies reinforces the competitive position. In this study, Spanish tourism clusters are identified using quantitative methods and the current validity of the economies of location that have made them possible are also analysed. Although all the identified clusters can be defined as mature and became less significant during the last decade in Spanish tourism, according to the results the creation of externalities measured in terms of higher generation of profit is higher in companies belonging to the tourism clusters than in those outside of them.     

Facilitating spatial thinking in world geography using Web-based GIS

Advocates for geographic information system (GIS) education contend that learning about GIS promotes students’ spatial thinking. Empirical studies are still needed to elucidate the potential of GIS as an instructional tool to support spatial thinking in other geography courses. Using a non-equivalent control group research design, this study examines the effect of using Web-based GIS in a world geography course on the development of students’ spatial thinking abilities. The findings indicate that Web-based GIS activities implemented in this study significantly enhanced students’ spatial thinking skills.     

Can Grassroots Mobilization of the Poorest Reduce Corruption? A Tale of Governance Reforms and Struggle against Petty Corruption in Bihar,India

The rural poor in India have long experienced corruption, exclusion from welfare schemes and the denial of rights. Critical accounts of development policy and practice advocate the need for pro‐poor governance reforms as well as effective mobilization of the poor for exercising their rights and entitlements. However, there is a dearth of empirical work which examines the following questions. What are the dynamics of such mobilization strategies in the environment of pro‐poor governance reforms? How do they affect local power relations from the perspective of the poorest social groups? And what are the challenges involved in sustaining struggles led by civil society organizations on behalf of the poorest and against petty corruption? This article addresses these questions in the context of a grassroots mobilization of Musahars (a Dalit caste group) in Bihar, one of the poorest provinces in India, which has recently initiated pro‐poor governance reforms. It explains what has or hasn't worked (and why) for the Musahars, in terms of their dealings with public officials. The authors argue that pro‐poor governance reforms and welfare schemes on their own are not sufficient; both grassroots mobilization and political will of the ruling dispensation are also necessary.     

REGIONAL VARIATIONS IN TECHNOLOGICAL CHANGE AND IN POTENTIAL GAINS FROM CONSOLIDATION AMONG U.S. COMMERCIAL BANKS

ABSTRACT. This paper investigates the regional variations in the impact of technological change and in gains from consolidation among U.S. commercial banks. We estimate a multiproduct translog cost function with the appropriate regional dummy variables. Technological change, ray scale economies and scale biases in technological change are estimated for each region. Furthermore, pairwise expansion path economies between all the regions are calculated to evaluate the potential gains from interregional consolidation. In general Southwest banks had the worst and Southeast the best technological change. There is substantial disparity across regions. It also appears that technological change increased the efficient size in the Midwest and Southwest regions and reduced it in the West, Northeast and Southeast. Banks in all regions show ray economies of scale, affirming the need for larger banks if output mix remains constant. Finally, the results support takeover of regional banks by the Money Center banks but not vice-versa, and favor consolidation among regional banks. The biggest potential gains accrue from mergers of Southeast banks with either Midwest or Southwest banks and the least gains are derived from mergers between Midwest and Southwest banks.