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Regional-level innovation policies and development activities, which are not only technology oriented but that also address intellectual issues, knowledge and absorptive capacity enhancement as sources of innovation and economic growth, are posing challenges regarding their management. One of the main challenges that arises with these new types of regional-level development activities relates to their evaluation because insufficient attention is paid to the design and building of the current evaluation frameworks suggested for the context of regional development. This study presents a framework to design and build a performance evaluation system to support the performance measurement of regional development activities. Utilizing operational-level development activities as an empirical example, this study aims to improve the understanding of performance evaluation in university–industry collaborations in the context of regional development. The presented framework highlights the role of evaluation as part of the learning process in regional development activities between universities and industrial and public-sector organizations. The results of the study show that it is also possible to use the evaluation system to increase understanding of the interplay between operational level development activities and regional development programmes.  相似文献   
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