Mapping the potential impact of synthetic biology on Australian foreign policy

Synthetic biology is an emerging technology that will impact on the future security and prosperity of Australia. As a discrete policy area synthetic biology has not been explored in relation to Australian foreign policy. To begin this process an understanding of Australia’s genetic endowment, Australia’s agricultural endowment and those security concerns novel to synthetic biology need to be developed. The convergence of the biological sciences and the information sciences is creating novel security concerns that impact on Australian sovereignty, both mainland and the Antarctic Territories, plant and animal health, and defence medical infrastructure. These concerns cross many traditional disciplinary and policy boundaries, an awareness of this is required and a nascent national practitioner community can develop this further. Drawing from work conducted by the US and UK synthetic biology practitioner communities, this article lays out the unique touch points synthetic biology has on Australian foreign policy.     

Ethologists in the Kindergarten: Natural Behavior,Social Rank,and the Search for the “Innate” in Early Human Ethology (1960s-1970s)

During the 1970s, ethologists at the German Max Planck Institute for Behavioral Physiology in Seewiesen started a series of research projects at several regional kindergartens in search of natural predispositions in human behavior. This so-called “Kindergarten Project” became one of the pillars of research activity at the newly founded Forschungsstelle für Humanethologie (Research Center for Human Ethology) where Irenäus Eibl-Eibesfeldt and a team of researchers set out to explore new fields of research for the discipline of ethology. Taking the research project conducted by biologist Barbara Hold on ranking behavior among kindergarten children as a vantage point, this paper explores the shift in ethology from animal to human behavior which occurred during the 1960s and 1970s. It analyzes how human ethologists coped with the methodological, conceptual, and ethico-political challenges which arose from crossing the human-animal divide. This article thus sheds light on the hitherto unwritten history of human ethology as it was developed at the MPI since the late 1960s.     

D’Arcy Thompson’s Legacy in Contemporary Studies of Patterns and Morphology

Abstract

D’Arcy Thompson’s views on the forms of biomaterials are assessed in the light of current thinking on biomorphology in selected areas of biology. It is clear that his guiding concepts — that biological materials are structured in response to physical forces, and that the biological and abiotic realms share many common features — remain valid. Advances in the physical and biological sciences are discussed, from quantum mechanics and molecular biology to liquid crystalline materials and macroscopic forms. These reveal Thompson’s clear-sighted view of the role of physical and mathematical sciences in biology, as well as his blind-spots.     

The disciplining of scientific communities

Abstract

Amidst ongoing concern with training students in the skills and knowledge necessary to contribute towards a knowledge-intensive economy, we explore how particular ‘epistemic subjects’ are produced within specific epistemic communities. We examine how social studies of science have probed the ‘disciplining’ practices that constitute scientific knowledge production, but have tended to overlook how students participate in, and become members of, epistemic communities. We propose that training contexts provide a window onto the disciplining processes through which scientific fields and their practitioners are co-produced. We offer an empirical example of an emerging scientific field that is working to establish community boundaries through the recruitment and training of university students. We explore how newcomers’ practices, values and identities are disciplined through participation in this nascent community whilst remaining open to negotiation and resistance. The conclusion calls for more scholarly attention to educational trajectories as processes through which disciplines and their disciples are produced.     

Origins of Molecular Neurobiology: The Role of the Physicists

The revolution in the foundations of physics at the beginning of the twentieth century suggested to several of its most prominent workers that biology was ripe for something similar. In consequence, a number of physicists moved into biology. They were highly influential in initiating a molecular biology in the 1950s. Two decades later it seemed to several of these migrants, and those they had influenced, that the major problems in molecular biology had been solved, and that it was time to move on to what seemed to them the final problem: the nervous system, consciousness, and the age-old mind-body problem. This paper reviews this “double migration” and shows how the hopes of the first generation of physicist-biologists were both realized and dashed. No new physical principles were discovered at work in the foundations of biology or neuroscience. On the other hand, the mind-set of those trained in physics proved immensely valuable in analyzing fundamental issues in both biology and neuroscience. It has been argued that the outcome of the molecular biology of the 1950s was a change in the concept of the gene from that of “a mysterious entity into that of a real molecular object” (Watson, 1965 Watson, JD. 1965. The Molecular Biology of the Gene, New York: Benjamin.  [Google Scholar], p.6); the gates and channels which play such crucial roles in the functioning of nervous systems have been transformed in a similar way. Studies on highly simplified systems have also opened the prospect of finding the neural correlatives of numerous behaviors and neuropathologies. This increasing understanding at the molecular level is invaluable not only in devising rational therapies but also, by defining the material substrate of consciousness, in bringing the mind-body problem into sharper focus.     

由经有数家、家有数说到括囊大典、贯通六艺——论郑玄通学的产生

郑玄通学的形成背景需要进一步探讨,晚清今文家关于两汉经学一直壁垒森严,到郑玄才被打破的说法影响还很大.其实汉代的经今古文学根本没有那么壁垒森严,"通"早已是一种大趋势,这一事实已有学者申说过,但其原因,笔者以为重要的是自王莽以后朝廷的导向,这是不容忽视的,经学作为政治统治学说,朝廷的引导往往在其中起着决定性的作用.     

天津博物馆文物库房部分文物与囊匣中霉菌的分离与鉴定

馆藏文物中的书画、古籍、档案、纺织品和竹木漆器等有机质文物,常常受到霉菌的破坏。为了解文物库房有机质文物中霉菌病害现状,寻找适合的防治方法,利用显微形态观察和分子生物学方法,对四个库房内文物材料与囊匣上滋生的霉菌进行采样、培养、分离和鉴定。实验分离出的14株菌株通过形态观察和分子生物学鉴定为6个属,包括毛壳菌属(Chaetomium)、畸枝霉属(Malbranchea)、曲霉属(Aspergillus)、派伦霉属(Peyronellaea)和枝孢属(Cladosporium)等,其中毛壳菌属数量最多,曲霉属次之,多数为能对文物产生危害的常见菌种,亟待采取有效防治措施。实验结果可为今后霉菌的防治工作提供依据。     

A distinct region of microarchitectural variation in femoral compact bone: Histomorphology of the endosteal lamellar pocket

Bone is a dynamic tissue, responding locally to differential mechanical loading and systemically to hormonal stimuli. Although the tendency is to consider compact bone a homogenous tissue, regional variations in microarchitecture are known to have quite different properties relating to processes of growth and mechanical loading. Specifically, we investigated an example of microstructural variation of the human, adult femoral endocortex, referred to here as the endosteal lamellar pocket (ELP). The femoral ELP is characterised as a histomorphological meta‐feature, made distinct from general circumferential lamellae by its hemicircumferential lamellar orientation, medial positioning, radially oriented Volkmann's canals and decreased presence of Haversian systems. Our preliminary observations of mid‐diaphyseal transverse thin‐ground sections demonstrate the ELP as a regular meta‐feature of adult human femora unearthed from the Maya archaeological site of Xcambó, Mexico. ELPs were easily identified in 38 of 45 examined individuals. Their size, shape and degree of secondary remodelling were variable. In comparison, ELP lamellae and those originating from the periosteum are divergent, or non‐concentric in orientation. This divergence, along with the ELP's medial position, suggest it forms during growth through endosteal modelling drift. Possible considerations for ELP formation and persistence with age are discussed as well as its implications for the study of bone dynamics during growth and activity. Further research is necessary to quantitatively measure the morphology of ELPs and to identify any co‐variance between ELP characteristics and age, sex or indicators of mechanical loading. Copyright © 2010 John Wiley & Sons, Ltd.     

In the Circulation Sphere of the Biomolecular Age: Economics and Gender Matter**

This contribution draws attention to the circulation of materialities and persons as a central feature in the constitution of experimental cultures. The protein and ribosome research at the Max Planck Society (MPG)—with a main focus on the research conducted by Brigitte Wittmann-Liebold at the Max Planck Institute for Molecular Genetics—serves as an example to highlight some of the central conditions that determined the material circulation in molecular biology: the very organizational framework of gender and economics. In doing so, this contribution argues for a historical narrative that stresses the conditions facilitating the circulation of technologies, materials, and personnel. Histories of this kind contribute to an integrated view of the scientific, technological, social, political, economic, and cultural specificities of experimental cultures.