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31.
G. Michael Taylor Stephanie Widdison Ivor N. Brown Douglas Young Theya Molleson 《Journal of archaeological science》2000,27(12):1133
Erosion in the 1960s resulted in exposure of human skeletal remains from a Norse Christian cemetery at Newark Bay, Orkney, Scotland. One set of remains showed osteological evidence of advanced lepromatous leprosy, but the absence of bones from the lower limbs precluded definitive diagnosis. The aim of the present study was to determine whether Mycobacterium leprae could be detected in bone extracts, as a means of confirming the diagnosis of leprosy. Bone samples were examined from the suspected leprosy case and from a second contemporary burial thought to be free of disease. DNA was amplified by polymerase chain reaction (PCR) using primers specific for a repetitive element (RLEP) characteristic of M. leprae. Additional PCR tests specific for Mycobacterium tuberculosis and for amelogenin (a human gene suitable for sex determination) were also applied to the samples. M. leprae DNA was detected only in the skull sample from the suspected leprosy case. The DNA sequence was identical to that found in present day isolates of M. leprae. Positive results were obtained only using a PCR reaction designed to amplify relatively short stretches of DNA (<175 bp), suggesting the microbial DNA had undergone extensive fragmentation. There was no evidence of M. tuberculosis DNA in bones from the leprosy suspect or control individual. The ability to recover ancient samples of DNA provides an opportunity to study long-term evolutionary changes that may affect the epidemiology of microbial pathogens. 相似文献
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Integrating Transportation Network and Regional Economic Models to Estimate the Costs of a Large Urban Earthquake 总被引:9,自引:0,他引:9
Sungbin Cho Peter Gordon James E. Moore II Harry W. Richardson Masanobu Shinozuka & Stephanie Chang 《Journal of regional science》2001,41(1):39-65
In this paper we summarize an integrated, operational model of losses due to earthquake impacts on transportation and industrial capacity, and how these losses affect the metropolitan economy. The procedure advances the information provided by transportation and activity system analysis techniques in ways that help capture the most important ecomonic implications of earthquakes. Network costs and origin-destination requirements are modeled endogenously and consistently. Indirect and induced losses associated with direct impacts on transportation and industrial capacity are distributed across zones and ecomonic sectors. Preliminary results are summarized for a magnitude 7.1 earthquake on the Elysian Park blind thrust fault in Los Angeles. 相似文献
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Marek W. Kozak 《European Planning Studies》2014,22(8):1604-1624
AbstractThere is more to success in destination development than just natural or cultural heritage and assets. Increasing globalization and changes in the realm of tourism, both in supply and demand, helped to identify and recognize new development factors. Skilful application of various drivers and mobilization of stakeholders around well-defined development objectives may bring unique results in terms of creating a multidimensional, complex and innovative mega-product. Until now, public administration has been unable to identify timely innovative features and the high promotional and social potential in the Palaces and Gardens Valley project. Instead, the main drivers behind its success have, therefore, to be sought outside public policies, among new development factors utilized by private sector and non-governmental organizations. However, in the long run, recently intensifying close cooperation of public and private bodies is a condition of further development of the project in question. 相似文献
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This contribution introduces an exercise in epistemic justice to the study of everyday nationalism in post‐conflict, transnational (local and international) encounters. It explores how everyday nationalism, in often unexpected and hidden ways, underpinned a cocreational, educational project involving several local (Albanian) and international (British based) university students and staff collaborating on the theme of post‐war memory and reconciliation in Kosovo. The set‐up resembled a microcosm of transnational social encounters in project collaborations in which the problem of nationalism, typically, is associated with one side only: here, the Kosovars. Guided by Goffman's (1982) social interactionist framework, the study employs selected participants' paraethnographic and auto‐ethnographic reflections of their project experiences and practices after the event in order to trace the everyday workings of mutual assumptions and constructions of a national self and other for all sides involved. In this, it explores how the project participants' asymmetric positioning within a wider, global context of unequal power relations shaped their vernacular epistemologies of belonging and identity. It thereby excavated what otherwise taken‐for‐granted criteria can become relevant in such local/international social encounters as reflected upon and how the enduring power imbalances underpinning these might best be redressed. 相似文献