Neuroscience in the Nobel perspective

The Nobel Prizes for Physiology or Medicine have included a relatively large number of awards for work in the neurosciences, or for work construed to have made a contribution to neuroscience. These are recognized in this article by brief explanations of the particular contribution that warranted this magnificent (and munificent) award. The first prizes in neuroscience were awarded five years after the initiation of the Nobel Foundation's program. Up to 2005, 28 prizes have been awarded for achievements in neuroscience to 52 individuals.     

On the energy cost of mental effort

The discovery of the Law of Conservation of Energy in the 1840s had consequences for psychological theory. Does the process of thinking involve a novel form of energy that is not recognized by physical science? E. L. Youmans (1821-1887) argued that "mental operations are dependent upon material changes in the nervous system." Kurd Lasswitz (1848-1910) introduced the term "psychophysical energy," based upon the electrical activity of the brain. At the beginning of the twentieth century Alfred Lehmann (1858-1921) claimed that intense mental effort leads to a net increase in oxygen utilization and regarded this as evidence of a specific psychic energy. His views were adopted and extended by Hans Berger (1873-1941). F. G. Benedict (1870-1957), drawing upon extensive experience with balance experiments conducted on humans in large-scale respiration calorimeters, concluded that mental effort probably had no effect upon the brain's metabolism. Modern approaches to the problem make use of PET imaging, which detects local changes in glucose utilization by the brain during cognitive activity.     

Seventeenth- and eighteenth-century commentators on the chemical composition of the brain

The period between 1600 and 1800 was one of great change in the history of science, generally, and in the history of chemistry, specifically. It opened with Francis Bacon's visionary recognition of the benefits to mankind that would accrue from the expansion of scientia and closed with the overthrow of the phlogiston hypothesis. New chemical knowledge resulted from the efforts of the alchemists, especially in Paracelsians, and of the phlogistic philosophers, some of it recorded by writers of magic books (Thorndike, 1958; Camporesi, 1989). The authors of these works reflected 'the general mentality ... imbued with magic, occult beliefs, unreal suggestions, 'voices', and 'rumours', ... 'errors' and 'prejudices'. In respect to brain chemistry there appeared, beside the fantastic, elements of fact that characterise this period as embracing the 'pre-history' of neurochemistry.