The myth of reserpine-induced depression: role in the historical development of the monoamine hypothesis

For five decades it has been generally accepted that reserpine, an antihypertensive and antipsychotic drug, causes depression. The discovery that reserpine depletes brain monoamines was an important factor in the development of the monoamine hypothesis of depression, and it continues to be widely cited in support of this hypothesis. The present paper argues that, contrary to prevailing belief, reserpine is not depressogenic. The reason for perpetuation of this myth is reluctance to discard the monoamine hypothesis. This hypothesis ushered the modern biochemical paradigm into psychiatry and is still of great importance. It serves as a heuristic to guide research, it enhances psychiatry's prestige, and it helps to validate and promote drug therapy for depression and other mental disorders.     

The serotonin hypothesis of schizophrenia: a historical case study on the heuristic value of theory in clinical neuroscience

Clinical examination of the reliability and coherence of the evidence concerning modern neurochemical theories of mental disorders has led some scholars to conclude that support for many of these theories is weak. Nevertheless, these theories continue to be widely promoted. One explanation that has been offered for continued adherence to questionable theory is that it stimulates and gives direction to research. The heuristic value of theory is examined in the present paper by tracing the discoveries that followed from an old theory of schizophrenia, which is--by current consensus--false. It is shown that the original serotonin hypothesis of schizophrenia did, in fact, lead to significant advances in neuropharmacology, neurology and psychiatry.     

Competitiveness through integration in the European Union Strategy for the Alpine Region: a ‘balanced development’ approach

In the last 10 years, the European Union has devoted specific attention and resources to the establishment of macro-regional strategies, with the objective of joining together transnational areas to favour the effective and organized management of common challenges. In most macro-regions, however, the identification of strategies to increase competitiveness is a rather difficult task, given the extreme internal diversity in economic activities. Focusing on the youngest macro-regional strategy – EUSALP – this paper highlights the specific combinations of territorial growth assets that allow to overcome the inefficient use of local abundant strategic resources, in line with a ‘balanced development’ approach. The results, obtained on the basis of a database gathered at NUTS3 level, are useful to provide policy suggestions to support the competitiveness of EUSALP through synergies and complementarities, according to a cooperation networks perspective.     

Kisar and the Archaeology of Small Islands in the Wallacean Archipelago

The occupation of small islands presents particular challenges for people largely related to limited terrestrial resources and susceptibility to natural disasters. Nevertheless, the challenges and risks inherent in maintaining stable populations on small islands can be offset or overcome through the use of maritime technologies and exchange networks. The archaeology of Here Sorot Entapa rockshelter (HSE) on Kisar Island in the Wallacean Archipelago provides an unparalleled record for examining these issues in Southeast Asia. Kisar is the smallest of the Wallacean islands known to have a Pleistocene occupation record, and one of the smallest permanently inhabited today. Our results indicate that Here Sorot Entapa was first occupied in the terminal Pleistocene by people with advanced maritime technology who made extensive use of local marine resources and engaged in social connections with other islands through an obsidian exchange network. As a result, populations appear to have been maintained on the island for approximately 6,000 years. In the early Holocene occupation at HSE ceased for unknown reasons, and the site was not reoccupied until the mid-Holocene, during which time a major change in the lithic resources can be observed and the exchange network appears to have ceased.     

Ethical consumption? There's an app for that. Digital technologies and everyday consumption practices

Ethical consumption mobile phone apps are increasingly popular. These apps allow consumers to scan the barcodes of products they are considering purchasing and determine whether or not they align with their ethics. App technologies are often applauded for their potential to provide consumers with targeted, crowd-sourced information about products while shopping and to foster more political, and less individualistic, consumption practices by connecting users to one another and to campaigns. There is a growing field of scholarship conceptually examining the role of information and digital technologies in ethical consumption. However, there is little empirical research on how consumers engage with ethical consumption apps in everyday ways. Drawing on an in-depth study with 21 participants, this paper explores how app use mediates people's experiences of ethical consumption. We contend that the app design structures and limits how individuals engage in ethically motivated consumption and influences their conceptualizations of ethical consumption as a political practice. We conclude by illustrating that critically examining what it means to be “ethical” in a digital world is a crucial area of research for geographers, particularly as these ethics play out through the everyday use of mobile technologies.     

Non-invasive characterization through X-ray fluorescence and neutron radiography of an ancient Japanese lacquer

Oriental lacquer artefacts represent very interesting objects of investigation, involving a huge variety of materials and manufacturing techniques. Lacquers are very attractive not only for their stylistic features but also for understanding the variety of production processes, time evolution, use and artistic applications involved in their manufacturing. Till recently, the research activity on these materials has been mainly based on standard, more or less invasive, analytical methods. With the aim to characterise a nineteenth century Japanese lacquer in a totally non-invasive and non-destructive way, in situ X-ray fluorescence (XRF) and neutron radiography (NR) have been employed. While XRF suggested an identification of the pigments embedded into superficial layers, NR allowed revealing, in a single measurement, the average bulk properties of the sample.