The myth of reserpine-induced depression: role in the historical development of the monoamine hypothesis

For five decades it has been generally accepted that reserpine, an antihypertensive and antipsychotic drug, causes depression. The discovery that reserpine depletes brain monoamines was an important factor in the development of the monoamine hypothesis of depression, and it continues to be widely cited in support of this hypothesis. The present paper argues that, contrary to prevailing belief, reserpine is not depressogenic. The reason for perpetuation of this myth is reluctance to discard the monoamine hypothesis. This hypothesis ushered the modern biochemical paradigm into psychiatry and is still of great importance. It serves as a heuristic to guide research, it enhances psychiatry's prestige, and it helps to validate and promote drug therapy for depression and other mental disorders.     

A Reappraisal of Dinas Powys: Local Exchange and Specialized Livestock Production in 5th- to 7th-century Wales

RESULTS OF THE analysis of a previously unstudied group of animal bone from Dinas Powys are tested against the original report and subsequent interpretations. Assumptions inherent in the initial sampling policy and analysis are discussed. The present interpretation explores the concept of social production in early medieval Wales.     

The serotonin hypothesis of schizophrenia: a historical case study on the heuristic value of theory in clinical neuroscience

Clinical examination of the reliability and coherence of the evidence concerning modern neurochemical theories of mental disorders has led some scholars to conclude that support for many of these theories is weak. Nevertheless, these theories continue to be widely promoted. One explanation that has been offered for continued adherence to questionable theory is that it stimulates and gives direction to research. The heuristic value of theory is examined in the present paper by tracing the discoveries that followed from an old theory of schizophrenia, which is--by current consensus--false. It is shown that the original serotonin hypothesis of schizophrenia did, in fact, lead to significant advances in neuropharmacology, neurology and psychiatry.     

A Minimal Representation for Dead-Reckoning Navigation: Updating the Homing Vector

A number of organisms are capable of traveling directly back to the origin of locomotion after following a circuitous outbound path, using dead-reckoning navigation. We describe a minimal representation that could be used for such navigation. It involves keeping track of only the polar coordinates of the origin of locomotion with respect to the observer's current location. An exact solution is provided first, followed by a simplified solution, then a solution involving linearization of trigonometric functions. The paper also examines performance attainable with these solutions and briefly considers ways in which the model might be modified to account for human navigation without reference to landmarks.     

Judicialization and Health Policy in Colombia: The Implications for Evidence‐Informed Policymaking

The existence of the tutela mechanism and the endemic weaknesses of the legislative and executive branches of the Colombian state have led to a de facto judicialization of health policymaking. The objective of evidence‐informed policy is to identify effective policy approaches and legitimize policy decisions. Questions arise about the basis on which judges take decisions with significant policy and budgetary consequences, and the forms of evidence they use to inform these. This article focuses on the extent to which courts take account of research evidence in judgements and assesses the implications for health policy in Colombia. We place these discussions in the context of a broader analysis of the ongoing reforms to the Colombian health system and the most recent literature on evidence‐informed policymaking. The judicialization of health policymaking offers a suboptimal means to achieve the objective of evidence‐informed policymaking. The emergence of a range of evidence advisory bodies in recent years is an attempt to address the issue of judicialization alongside the other constitutional and political weaknesses Colombia faces.