Charcot-Marie-Tooth disease from first description to genetic localization of mutations

Charcot-Marie-Tooth disease is a hereditary motor and sensory neuropathy first described in 1886. Our increasing knowledge of this disease correlates well with the development of methods used in neurology over the past 100 years. Although its physiopathology and treatment is still not fully understood, current developments in techniques are opening the way to future discoveries. We have divided its history into three theoretical periods: the first from 1886 to 1956, which was devoted to clinical and pathological study of the disease; the second from 1956 to 1982, which saw the development of electromyography in the investigation of neuromuscular diseases; and the last and current period based upon genetic research, using the methods of molecular biology.     

Neutron activation analysis of stone from the Chadron Formation and a Clovis Site on the Great Plains

Cryptocrystalline silicates from the Chadron Formation were widely used by prehistoric human groups in the Great Plains of North America. There are two documented quarry areas: Flattop Butte in Colorado and the White River Badlands of South Dakota. Cryptocrystalline silicates from these sources are visually indistinguishable, making it difficult to determine the sources of artefacts found at archaeological sites. In this investigation, neutron activation analysis is used to distinguish the two sources. This technique also identifies lithic material from the Clovis-age Eckles site in Kansas as being from Flattop Butte.     

ANALYSIS OF THEORETICAL,METHODOLOGICAL AND EMPIRICAL RESEARCH IN THE JOURNAL OF REGIONAL SCIENCE*

ABSTRACT. This paper examines the impacts of JRS articles in the areas of theory, methods and empirical analysis, as represented by subsequent citations reported in the Social Sciences Citation Index. A model relating the mix of theoretical, methodological and empirical research published in the JRS to subsequent citations is estimated. The time distribution of theoretical and empirical citations also indicates that the knowledge diffusion process in these two areas may be segmented.     

Heterodoxe lehren und ihre widerlegung im Kālacakra-tantra

Summary At the end of the second chapter of the Buddhist Klacakra-Tantra (dated c. 10th century) we find a group of verses in which several doctrines are characterized and criticized: Brahmanism, Vaisnavism, aivism, materialism, Islam and Jainism. Moreover the text refers to Buddhism itself as well as the so-called heterodox Buddhist schools. It is the only old Sanskrit text known until now in which the Islam is mentioned and recognized as a doctrine.     

The Effect of Job Advertising Policies on Interregional Labor Migration

A simulation model of a multiregional labor migration process is developed. Information about employment conditions in alternative regions is transmitted in a combination of three channels. The adopted emission policies directly control the amount of information available to potential migrants which, in turn, determines the potential migrant's perception of the level of welfare in the other regions. The effect of several different advertising policies on migration streams is examined. Employers can pursue a number of policies designed to maximize their return. Other agencies adopt policies that facilitate the matching process between unemployed workers and vacant jobs. Results are presented for a number of simulation experiments.     

LITERATURE REVIEWS

Books reviewed in this article:
A. Comments
B. Book Notes
Abney, Glenn and Thomas P Lauth The Politics of State and City Administration
Adams, William J and Christran Stoffaes, (eds) French Industrial Policy
Binkin, Martin, Military Technology and Defense Manpower
Elazar, aniel J Cities of the Prairie Revisited The Closing of the Metropolitan Frontier
Ginsberg, Benjamin The Captive Public How Mass Opinion Promotes State Power
Heath, Robert L and Richard Alan Nelson Issues Management Corporate Public Policymaking in an Information Society
Hunt, Morton Profiles of Social Research The Scientific Study of Human Interactions
Kaplan, Marshall and Peggy Cuciti (eds) The Great Society and itsLegacy wenty Years of U S Social Policy
Katz, Michael B In the Shadow of the Poorhouse A Social History of Welfare in America
Katzmann, Robert A. Institutional Disability The Sage of Transporation Policy for the Disabled
Liroff, Richard A Reformaing Air Pollution Regulation The Toil Trouble of EPA's Bubble
Lowi, Theodore J The Personal President Power Invested Promise Unflfilled
Mead, Walter J, Asbjorn Moseidjord, Dennis D Muraoka, and Philip E Sorenson Offshore Lands. Oil and Gas Leasing and Conservation on th Outer Continental Shelf
Muskie, Edmund, Kenneth Rush, and Kenneth W Thompson The President, the Congress and Foreign Policy
Openshaw, Stan Nuclear Power. Siting and Safety
Peters, B Guy American Public Policy Promise and Performance
Rosentraub, Mark S, (ed) Urban Policy Problems Federal Policy and Institutional Change
Story, Dale Industry, the State, and Public Policy in Mexico
Taylor, Ralph B, (ed) Urban Neighborhoods Research and Policy
Wesson, Robert and Heraldo Munoz, (eds) Latin American Views of U S Policy
Winston, Brian isunderstanding Media
Zurcher, Louis A, Milton L Boykin, and Hardy L Merritt Citizen Sailors in a Changing Society Policy Issues for Manning the United StatesNaval Reserve