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Epilepsy is a major public health threat in the developing world, with much higher prevalence and incidence rates than those observed in developed countries. At present, one of the most common causes for epilepsy worldwide is the parasitic worm, Taenia solium, and the associated neurocysticercosis (NCC) that may often result from this infestation. Worm infestation was already recognized as a cause of epilepsy by the middle of the 18th century. Helminths and their effects on health were a daily medical concern in the 18th and 19th centuries--with prevailing views ranging from the beneficial effects of the presence of adult worms in the gut, to considering them as culprits for a wide variety of diseases. A number of cases followed longitudinally by various nineteenth-century French physicians showed that there was good reason to believe that the verminous influence on seizures was real, as the expulsion of the T. solium often coincided with a notable amelioration of symptoms. Several theories were proposed to account for how the worms could lead to Epilepsia nervosa, including notions of competition for nutritional resources between the host and the parasite, and irritation of the medulla and of peripheral nerve endings predisposing to epileptiform episodes. Recently, after almost a century of quiet, interest in the neurological effects of helminths has been rekindled, due in part to the growing number of cases in the United States with NCC-related neurological disorders. In this article, we review the history of our understanding of the relationship between seizure disorders and parasitic worms, and we relate this history to contemporary epidemiologic and public health issues in developing countries. 相似文献
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Radcliff PB 《Gender & history》2001,13(3):498-523
This article analyses the contestation over female citizenship in Spain's transition to democracy in the mid 1970s. It posits that the transition opened up a discursive space for the construction of a new concept of female citizenship, which was filled with competing images of female citizens, from the Francoist housewife to the consumer activist to the feminist. Through a close reading of the democratic press, the article explores the contradictions and tensions involved in imagining a new female citizen for a democratic Spain. With a focus on the representation of feminist citizenship, the article argues that the central tension surrounding female citizenship was the contradiction between new modes of female participation, new sets of rights and a framework of meaning which could not make sense of these changes. As a result, there was no comfortable place for the female citizen in the emerging master narrative of the transition. 相似文献