Seleucia Pieria: an ancient harbour submitted to two successive uplifts

Historical sources ascribe the foundation of Seleucia (Seleukeia) Pieria to Seleucos I Nikator, shortly before the foundation of Antioch in the late 4th century BC. The Seleucia Pieria site seems however to have been inhabited earlier, perhaps from around 700 BC, possibly by a Greek population under an Assyrian ruler. The city became of considerable military importance during the wars between the Ptolemies and the Seleucids; it was occupied by the Romans in the 1st century BC, but had practically disappeared in the 6th century AD.
Geomorphological surveys in the area have revealed the existence of elevated marine notches and rims bioconstructed by vermetids, oysters and calcareous algae, which occasionally erode or intersect the archaeological sites, showing that two rapid land uplift movements, probably of seismic origin, took place during the late Holocene. The first movement, which occurred about 2500 ± 100 years bp, was the strongest one and caused a local vertical displacement of about 1.7 m, which may have severely affected the earlier Greek settlement. Though several earthquakes are reported to have occurred in the area during the following ten centuries, none of them seem to have been strong enough to cause significant vertical displacements. The second movement occurred around 1400 years bp, probably in May 526 AD, when a great earthquake followed by tsunami waves is known to have caused devastating damage in Antioch and Seleucia. According to geomorphological data supported by several radiocarbon dates, the earthquake was accompanied by a 0.7 to 0 8 m upheaval. This seismotectonic event also caused a rapid silting of the Seleucia Pieria closed harbour basin and entrances, thus preventing its further use.     

The Analysis of Spatial Association by Use of Distance Statistics

Introduced in this paper is a family of statistics, G, that can be used as a measure of spatial association in a number of circumstances. The basic statistic is derived, its properties are identified, and its advantages explained. Several of the G statistics make it possible to evaluate the spatial association of a variable within a specified distance of a single point. A comparison is made between a general G statistic and Moran's I for similar hypothetical and empirical conditions. The empirical work includes studies of sudden infant death syndrome by county in North Carolina and dwelling unit prices in metropolitan San Diego by zip-code districts. Results indicate that G statistics should be used in conjunction with I in order to identify characteristics of patterns not revealed by the I statistic alone and, specifically, the G_i and G_i* statistics enable us to detect local “pockets” of dependence that may not show up when using global statistics.     

Charcot-Marie-Tooth disease from first description to genetic localization of mutations

Charcot-Marie-Tooth disease is a hereditary motor and sensory neuropathy first described in 1886. Our increasing knowledge of this disease correlates well with the development of methods used in neurology over the past 100 years. Although its physiopathology and treatment is still not fully understood, current developments in techniques are opening the way to future discoveries. We have divided its history into three theoretical periods: the first from 1886 to 1956, which was devoted to clinical and pathological study of the disease; the second from 1956 to 1982, which saw the development of electromyography in the investigation of neuromuscular diseases; and the last and current period based upon genetic research, using the methods of molecular biology.     

The history of the neurological examination. Part 1: ancient and pre-modern history--3000 BC to AD 1850

Every time a physician conducts a neurological examination the process continues a biomedical search for understanding the nervous system which is as ancient as the earliest civilizations in human history. Most of the modern neurological examination evolved in a short time span, between 1850 and 1914, but the origins of neurology as a medical quest for knowledge date to the first evolution of urban life, in the valleys of the Euphrates and the Nile. This paper reviews this history in two chronological segments: part 1 up to 1850 and part 2 the subsequent period.