The myth of reserpine-induced depression: role in the historical development of the monoamine hypothesis

For five decades it has been generally accepted that reserpine, an antihypertensive and antipsychotic drug, causes depression. The discovery that reserpine depletes brain monoamines was an important factor in the development of the monoamine hypothesis of depression, and it continues to be widely cited in support of this hypothesis. The present paper argues that, contrary to prevailing belief, reserpine is not depressogenic. The reason for perpetuation of this myth is reluctance to discard the monoamine hypothesis. This hypothesis ushered the modern biochemical paradigm into psychiatry and is still of great importance. It serves as a heuristic to guide research, it enhances psychiatry's prestige, and it helps to validate and promote drug therapy for depression and other mental disorders.     

The serotonin hypothesis of schizophrenia: a historical case study on the heuristic value of theory in clinical neuroscience

Clinical examination of the reliability and coherence of the evidence concerning modern neurochemical theories of mental disorders has led some scholars to conclude that support for many of these theories is weak. Nevertheless, these theories continue to be widely promoted. One explanation that has been offered for continued adherence to questionable theory is that it stimulates and gives direction to research. The heuristic value of theory is examined in the present paper by tracing the discoveries that followed from an old theory of schizophrenia, which is--by current consensus--false. It is shown that the original serotonin hypothesis of schizophrenia did, in fact, lead to significant advances in neuropharmacology, neurology and psychiatry.     

Can't find a pulse? Celtic bean (Vicia faba L.) in British prehistory

Archaeobotanical research on prehistoric crops in Britain has primarily focussed on cereals and the potential importance of alternative crops, such as pulses, has often been overlooked. This paper reviews evidence for Celtic bean (Vicia faba L.) in British prehistory, using a database of archaeobotanical assemblages from 75 sites. Celtic bean is rare in the Neolithic – Early Bronze Age and it only becomes frequent from the Middle Bronze Age (ca. 1500 cal BC) onwards, particularly in southern England. Though there is a paucity of evidence at many sites, it is suggested that this reflects a preservation bias and in some areas at least, Celtic bean formed an important element of past agricultural systems.     

Exploring the Backstage of Victorian Respectability

This paper shares Andersson’s interest in exploring the ‘backstage’ of Victorian civility and respectability. The adroit media manipulation of high-status leading reformers and their associations and societies, with their often overlapping membership, has accorded them an inflated importance as a representation of the Victorian Age, and can distort our understanding. The argument here begins by problematizing the ways some historians have made use of contemporary statistics and terms such as ‘respectability’ or ‘vice’. For the Victorians these carried multiple meanings and cultural resonances, partially dependent on identities of class, gender, generation, Tory or Liberal political orientation, attitude to faith, and ethnicity. This meant that the complex nuances of understanding attached to activities sometimes labelled as unrespectable ‘vices’ such as drinking, sexual transgression and gambling could make them acceptable in a variety of cultural contexts despite the opposition of vociferous anti-‘vice’ groups. The paper concludes with a brief exploration of the potentiality of visual and digital resources for delving deeper into such issues.     

Global Value Chains,Industrial Policy and Economic Upgrading in Ethiopia's Apparel Sector

This article examines whether low-income countries can still benefit from participating in manufacturing global value chains (GVCs) in terms of broader industrial development in a global context of greater competition and higher requirements. It contends that developing internationally competitive local firms and domestic linkages, in addition to upgrading, is crucial for participation in GVCs to drive industrialization. The study focuses on Ethiopia's recent experience with developing an apparel export industry through strategic industrial policy. Based on original empirical data collected through firm-level surveys and interviews with government officials, industry experts and buyers, the article analyses the upgrading and localization trajectories of foreign and local apparel-exporting firms. It argues that value-capture benefits in assembly positions in apparel GVCs have become more difficult. The potential for localization benefits depends on the type of global buyers and foreign producers and their levels of embeddedness, but whether this potential is realized also depends on local firm characteristics and related industrial policy. Ethiopia's industrial policy has been relatively successful regarding national economy linkages, but less successful in developing competitive local export firms due to a weak local manufacturing tradition combined with a global context that has led to a supplier squeeze.     

A radiocarbon chronology for the complete Middle to Upper Palaeolithic transitional sequence of Les Cottés (France)

The Middle to Upper Palaeolithic transition is the key period for our understanding of Neanderthal and modern human interactions in Europe. The site of Les Cottés in south-west France is one of the rare sites with a complete and well defined sequence covering this transition period. We undertook an extensive radiocarbon dating program on mammal bone which allows us to propose a chronological framework of five distinct phases dating from the Mousterian to the Early Aurignacian at this site. We found that the Mousterian and Châtelperronian industries are separated from the overlying Protoaurignacian by a gap of approximately 1000 calendar years. Based on a comparison with Upper Paleolithic sites in Europe we see an overlap in the ages of Châtelperronian industries and Aurignacian lithic assemblages, which are usually associated with Anatomical Modern Humans, which is consistent with an acculturation at distance model for these late Neanderthals. The Proto and Early Aurignacian appear contemporaneous indicating that this transition was rapid in this region. Anatomically Modern Humans are present at the site of Les Cottés at least at 39,500 cal BP roughly coincident with the onset of the cold phase Heinrich 4.     

Radiocarbon reservoir effects in human bone collagen from northern Iceland

Human bone collagen from a series of Icelandic human pagan graves was radiocarbon (¹⁴C) dated to aid understanding of early settlement (landnám) chronologies in northern Iceland. These individuals potentially consumed marine protein. The ¹⁴C age of samples containing marine carbon requires a correction for the marine ¹⁴C reservoir effect. The proportion of non-terrestrial sample carbon was quantified via measurement of carbon stable isotopes (δ¹³C) using a simple mixing model, based on δ¹³C measurements of archaeofaunal samples. Non-terrestrial carbon was also quantified in six pig bones from the archaeofaunal dataset. Assuming all non-terrestrial carbon in human and pig bone collagen was marine-derived, calibrated age ranges calculated using a mixed IntCal09/Marine09 calibration curve were consistent with an early settlement date close to landnám, but several samples returned pre-landnám age ranges. Measurements of nitrogen stable isotopes (δ¹⁵N) strongly suggest that many of the human bone collagen samples contain freshwater diet-derived carbon. Icelandic freshwater systems frequently display large freshwater ¹⁴C reservoir effects, of the order of 10,000 ¹⁴C years, and we suggest that the presence of freshwater carbon is responsible for the anomalously early ages within our dataset. In pig samples, the majority of non-terrestrial carbon is freshwater in origin, but in human samples the proportion of freshwater carbon is within the error of the marine component (±10%). This presents a major obstacle to assessing temporal patterns in the ages of human remains from sampled graves, although the majority of grave ages are within the same, broad, calibrated range.