The myth of reserpine-induced depression: role in the historical development of the monoamine hypothesis

For five decades it has been generally accepted that reserpine, an antihypertensive and antipsychotic drug, causes depression. The discovery that reserpine depletes brain monoamines was an important factor in the development of the monoamine hypothesis of depression, and it continues to be widely cited in support of this hypothesis. The present paper argues that, contrary to prevailing belief, reserpine is not depressogenic. The reason for perpetuation of this myth is reluctance to discard the monoamine hypothesis. This hypothesis ushered the modern biochemical paradigm into psychiatry and is still of great importance. It serves as a heuristic to guide research, it enhances psychiatry's prestige, and it helps to validate and promote drug therapy for depression and other mental disorders.     

The serotonin hypothesis of schizophrenia: a historical case study on the heuristic value of theory in clinical neuroscience

Clinical examination of the reliability and coherence of the evidence concerning modern neurochemical theories of mental disorders has led some scholars to conclude that support for many of these theories is weak. Nevertheless, these theories continue to be widely promoted. One explanation that has been offered for continued adherence to questionable theory is that it stimulates and gives direction to research. The heuristic value of theory is examined in the present paper by tracing the discoveries that followed from an old theory of schizophrenia, which is--by current consensus--false. It is shown that the original serotonin hypothesis of schizophrenia did, in fact, lead to significant advances in neuropharmacology, neurology and psychiatry.     

Can't find a pulse? Celtic bean (Vicia faba L.) in British prehistory

Archaeobotanical research on prehistoric crops in Britain has primarily focussed on cereals and the potential importance of alternative crops, such as pulses, has often been overlooked. This paper reviews evidence for Celtic bean (Vicia faba L.) in British prehistory, using a database of archaeobotanical assemblages from 75 sites. Celtic bean is rare in the Neolithic – Early Bronze Age and it only becomes frequent from the Middle Bronze Age (ca. 1500 cal BC) onwards, particularly in southern England. Though there is a paucity of evidence at many sites, it is suggested that this reflects a preservation bias and in some areas at least, Celtic bean formed an important element of past agricultural systems.     

Exploring the Backstage of Victorian Respectability

This paper shares Andersson’s interest in exploring the ‘backstage’ of Victorian civility and respectability. The adroit media manipulation of high-status leading reformers and their associations and societies, with their often overlapping membership, has accorded them an inflated importance as a representation of the Victorian Age, and can distort our understanding. The argument here begins by problematizing the ways some historians have made use of contemporary statistics and terms such as ‘respectability’ or ‘vice’. For the Victorians these carried multiple meanings and cultural resonances, partially dependent on identities of class, gender, generation, Tory or Liberal political orientation, attitude to faith, and ethnicity. This meant that the complex nuances of understanding attached to activities sometimes labelled as unrespectable ‘vices’ such as drinking, sexual transgression and gambling could make them acceptable in a variety of cultural contexts despite the opposition of vociferous anti-‘vice’ groups. The paper concludes with a brief exploration of the potentiality of visual and digital resources for delving deeper into such issues.     

Global Value Chains,Industrial Policy and Economic Upgrading in Ethiopia's Apparel Sector

This article examines whether low-income countries can still benefit from participating in manufacturing global value chains (GVCs) in terms of broader industrial development in a global context of greater competition and higher requirements. It contends that developing internationally competitive local firms and domestic linkages, in addition to upgrading, is crucial for participation in GVCs to drive industrialization. The study focuses on Ethiopia's recent experience with developing an apparel export industry through strategic industrial policy. Based on original empirical data collected through firm-level surveys and interviews with government officials, industry experts and buyers, the article analyses the upgrading and localization trajectories of foreign and local apparel-exporting firms. It argues that value-capture benefits in assembly positions in apparel GVCs have become more difficult. The potential for localization benefits depends on the type of global buyers and foreign producers and their levels of embeddedness, but whether this potential is realized also depends on local firm characteristics and related industrial policy. Ethiopia's industrial policy has been relatively successful regarding national economy linkages, but less successful in developing competitive local export firms due to a weak local manufacturing tradition combined with a global context that has led to a supplier squeeze.     

From expectations to aspirations: State modernisation,urban policy,and the existential politics of welfare in the UK

The form and character of the British welfare state is undergoing another round of reform. Welfare modernisation now focuses on the creation of ‘aspirational citizens’ in deprived areas or communities, individuals, and groups who will ‘better’ themselves and become more like an imagined social ‘mainstream’. Old-fashioned policies that promoted expectations of improvement have been replaced by this focus on encouraging new forms of self-reliant, aspirational citizenship. This paper interrogates the nature of this discursive shift. It argues that an existential politics, built around notions of aspiration, is being rolled-out across the British welfare state and that this has significant material and political implications. It begins by critically assessing the terms aspiration and expectation. It then draws on recent urban and spatial policy agendas to empirically explore the nature of this shift and its wider effects on urban societies, economies, and environments before concluding with a discussion of possible future research directions and agendas.     

Determination of ancient geomagnetic strengths from specimens with multi-component magnetizations

Two methods have been devised for analysing data from Thellier-type investigations of specimens with two components of magnetization in different directions. Some results obtained on laboratory test specimens are presented and discussed.     

Politicisation but not Responsiveness: Preferences and Experiences of New Zealand Councillors

This article reports the responses of New Zealand local government councillors concerning their preferences for, and experiences of, council officer employment; and the values councillors perceive that council officers adopt in their dealings with councillors. This study received responses from slightly fewer than one hundred councillors in New Zealand local government out of 247 and therefore, the results presented here should be viewed as indicative only because of the small sample. Nevertheless the survey found that 54 per cent to 77 per cent would prefer to have influence over council officer employment, with council officers displaying deference to the authority of councillors. Councillors prefer to have frank and fearless advice but they prefer not to be under pressure from council officers to accept that advice. This ensures that they obtain the type of support they need to carry out the tasks and responsibilities that have been conferred on local authorities; and they – the councillors rather than council officers – remain in control of the council affairs.