Evolution of the Concept of ‘Extracellular Matrix’ in the Brain

The question as to whether an extracellular matrix exists between cells in the adult brain has been debated since the end of the last century. In the early years, zones containing neuropil and glial processes were mistakenly believed to represent this substance. But Golgi's discovery of the “perineuronal net” paved the way for future study of the true extracellular matrix. In the 1950s, application of histochemical techniques established the existence of interstitial material between nerve cells. Unfortunately the similarity between the pericellular distribution of this material and Golgi's “pericellular nets” was overlooked. The detection of an extracellular volume fraction in the central nervous system furnished further indirect proof for the existence of an extracellular matrix in the brain. However, the repeated failure of electron microscopy to reveal a substantial space between cell processes undermined the acceptance of the concept of “extracellular matrix” in the central nervous system. Nowadays this concept has, however, been firmly established.     

What Kind of Entrepreneurship Drives Regional Development in European Non-core Regions? A Literature Review on Empirical Entrepreneurship Research

Regional policies across Europe aim at stimulating regional development in non-core regions through fostering entrepreneurship. However, the policies applied in non-core regions and the concepts of entrepreneurship these policies are based on differ. Therefore, the goal of this review is to identify different understandings of entrepreneurship and their role for regional development processes in European non-core regions. To this end, empirical studies investigating entrepreneurship in European non-core regions from 1999 to 2011 were analysed. The results of the analysis are presented along three drivers and outcomes of entrepreneurship identified inductively from the literature: innovation, social capital and institutional change. We made out seven different types of entrepreneurship in European non-core regions. These seven types of entrepreneurship comprise particular mechanisms through which they stimulate regional development. Further research should study the interplay between these different mechanisms of regional development in non-core regions which may induce a more territorial approach to understand entrepreneurship in non-core regions across Europe.     

Effects of Geometrical Features on the Seismic Response of Historical Masonry Towers

ABSTRACT

Historical masonry structures are often located in earthquake-prone regions and the majority of them are considered to be seismically vulnerable and unsafe. Historical masonry towers are slender structures that exhibit unique architectural features and may present many inadequacies in terms of seismic performance. The seismic protection of such typologies of structures and the design of effective retrofitting interventions require a deep understanding of their behavior under horizontal loads. This paper presents the results of the seismic performance evaluation of historical masonry towers located in Northern Italy. A large set of case studies is considered, comprising a significant number of towers with high slenderness and marked inclination. First, a preliminary assessment of the dynamic behavior of the different towers is carried out through eigenfrequency analyses. Then, non-linear dynamic simulations are performed using a real accelerogram with different peak ground accelerations. A damage plasticity material model, exhibiting softening in both tension and compression, is adopted for masonry. The huge amount of results obtained from the non-linear dynamic simulations allows a comparative analysis of the towers to be performed in order to assess their seismic vulnerability and to show the dependence of their structural behavior on some geometrical characteristics, such as slenderness, inclination, and presence of openings and belfry. The evaluation of different response parameters and the examination of tensile damage distributions show the high vulnerability of historical masonry towers under horizontal loads, mainly in the presence of marked inclination and high slenderness. Some general trends of the seismic behavior of the towers are deduced as a function of the main typological features.     

Success of a flexible behavior. Considerations on the manufacture of Late Epigravettian lithic projectile implements according to experimental tests

It is generally recognized that the function and modality of hafting are the main factors influencing mental templates, and consequently, stone tool standardization. But what role do technical knowledge and traditions play? In this study, we investigate the interaction between mental templates and technological choices in the manufacture of Late Epigravettian projectile implements. The examined specimens come from different dwelling phases of the Dalmeri rock shelter (Italian Alps). Technological analyses suggest that lithic production systems gradually simplified their structure over time, implying a shift in technical investment from shaping on the core to a subsequent shaping on the derived flake blank. However, correlations between the dimensions and morphological features among the armatures from the different units suggest that mental templates remained unchanged throughout the Alleröd. Experimentation attests to the frequent combined application of different retouching techniques. Further, the variability in their arrangement denotes the absence of strict rules and the Epigravettian capability to recognize the most situationally suitable method. In the Dalmeri rock shelter, the standardization of lithic projectile implements is therefore a result of flexibility in retouching, framed in a production system characterized by a progressive simplification. A such rapidly produced and responsive technology must have been encouraged by Late Glacial climatic and environmental changes and the occupation of alpine territories previously inaccessible. Thus, the flexibility of technical behaviors turns out to be a key element in the transformation of Late Epigravettian societies during this period, enabling them to adapt and evolve in response to environmental, social, and economic changes.     

A Further Proposal for the Hull Lines of the Madrague de Giens Ship (c.70 BC)

A review of studies carried out since 1978 on the Madrague de Giens ship remains have enabled a reassessment of the vessel's shell‐first construction process. Hypotheses concerning moulding criteria are developed, with the profile (sheer plan), main cross section (body plan), and active sections and reference planks used to mould the hulll proposed and evaluated. These are compared to the Marsala (3rd century BC), and Yass?ada 2 (4th century AD) ships, which have similar wine‐glass‐shaped bottoms. Some aspects of these moulding criteria appear common to those used in the Mediterranean during the Middle Ages and the Renaissance.     

The impact of EU Objective 1 funds on regional development: Evidence from the U.K. and the prospect of Brexit

Brexit means that regions of the United Kingdom will lose access to the EU Cohesion Policy. Have EU funds been effective, and what might be the consequences of an interruption of EU financial support? This paper studies the impact of “Objective 1” funding—the highest form of EU aid—in Cornwall and South Yorkshire, two of the U.K.’s most subsidized regions. Counterfactual methodologies assessing their labor market and economic performance provide evidence of a positive effect of EU Objective 1 funds. When in 2006 South Yorkshire lost Objective 1 eligibility, this massively reduced its share of EU funds and the region was unable to sustain the gains obtained in previous years. This suggests that while Structural Funds may be effectively improving socio‐economic conditions of poorer regions, the performance of subsidized areas could be deeply affected by a reduction (or worse, an interruption) of EU aid.