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Cervantes's deathbed novel, The Trials of Persiles and Sigismunda: A Northern Story, uses the pilgrimage of the two eponymous protagonists to show them as exemplars of the virtues not only necessary for ordinary life, but also those qualities essential to true leadership. The novel constitutes Cervantes's final written words, barely completed in partial rough draft before he expired, and accordingly might be considered his last words on the ideas and traits most important for human flourishing.  相似文献   
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We have amplified Mycobacterium leprae DNA from the skeleton of an adult human female exhibiting signs of lepromatous leprosy (LL). The remains were excavated from the site of Devkesken 6 on the Ustyurt plateau of Uzbekistan and date to between the 1st and 4th centuries AD. Recovered DNA was fragmented but of sufficient quality and quantity to allow a series of biomolecular genotyping methods to be applied. These methods included variable nucleotide tandem repeat (VNTR) typing of two microsatellite and one minisatellite regions and also single-nucleotide polymorphism (SNP) typing for nine informative loci.Genotyping showed that the causative strain of M. leprae exhibited a SNP-type 3 profile, characteristic of cases associated geographically with Europe and North Africa. Further SNP sub-typing was performed and the data obtained from the Uzbek leper was compared with the same loci amplified from a case of LL recovered from Blackfriars, Ipswich, UK dating to between the 13th and 16th centuries AD. Unique group 3 subtypes were found in both the Uzbek case and Ipswich 1914. These appear to be ancestral to recent type 3 strains. Mycolic acid analysis confirmed the presence of M. leprae in the Uzbek samples. Phylogenetically informative SNPs and other polymorphic loci will contribute to the study of human migrations, as well as the origin and spread of leprosy.  相似文献   
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We report on the detection, in a sediment core drilled in Lake Le Bourget (French Alps), of a fossil molecule (miliacin) that was synthesized by broomcorn millet cultivated in the watershed, and then exported to the sediment. The variation in abundance of this molecule allows us reconstructing the history of millet cultivation around Lake Le Bourget. Our results support the introduction of millet around −1700 BC in the region. After an intensive cultivation during the Late Bronze Age, the failure of millet cropping during the Hallstatt period coincides with a phase of climatic deterioration. Millet cultivation recovers during the Roman and Mediaeval periods before falling most probably due to the introduction of more productive cereals. These pioneering results constitute the first continuous record of an agrarian activity covering the last 6000 years and emphasize the close relationships between local hydrology, land use and agro-pastoral activities around Lake Le Bourget.  相似文献   
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Despite an increasing number of studies assessing the importance of institutions as regards to accountability, it still remains to be known whether and how an individual's national and regional identity shapes the attribution of responsibilities in multi‐level settings. By focusing on the economic crisis that affected Europe since 2008, we argue that identity‐based assessments of responsibility for the crisis will occur solely among individuals who hold exclusively national or regional identities and who live in regions that have nationalist aspirations. This will be in contrast to individuals that have exclusively identities who live in regions that lack nationalist aspirations, as well as dual‐identity individuals, irrespective of where they live. We test our arguments by using data from Catalonia and Madrid (Spain) and Bavaria and Lower Saxony (Germany). In line with our expectations, our results show that, in minority nationalist regions such as Catalonia, an individual's identity will crucially determine which level of government is blamed for the economic crisis, while this will not occur in regions with no nationalist aspirations. The article reveals the existence of an additional determinant of blame attribution in some specific multi‐level arrangements and contributes to the understanding of the tensions between identity politics and blame avoidance.  相似文献   
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Analyses of the Provisional IRA in Northern Ireland tend to underplay the influence of political strategy in the 1970s, preferring to emphasise militarism. Similarly, the persistence of militarism in the 1980s is often obscured by the attention paid to a ‘new’ republican political orientation. This article seeks to draw attention to the IRA's evolving attitude to the ‘problem’ of Ulster unionism, and republicanism's various estimations of the likely efficacy of violence throughout the period. Republicanism is best understood as a deeply rooted working-class ethno-nationalist movement interacting closely with the other agents of the Northern Ireland conflict: constitutional nationalism, unionism and the British government. ‘Armed struggle’ became a declining asset for republicanism as it came to be seen less as a form of ‘popular guerrilla warfare’ and more as ‘terrorism’. 1 [1] For valuable advice, thanks to Prof. Roy Foster. Opinions expressed are my own. View all notes  相似文献   
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