Mycobacterium leprae genotype amplified from an archaeological case of lepromatous leprosy in Central Asia

We have amplified Mycobacterium leprae DNA from the skeleton of an adult human female exhibiting signs of lepromatous leprosy (LL). The remains were excavated from the site of Devkesken 6 on the Ustyurt plateau of Uzbekistan and date to between the 1st and 4th centuries AD. Recovered DNA was fragmented but of sufficient quality and quantity to allow a series of biomolecular genotyping methods to be applied. These methods included variable nucleotide tandem repeat (VNTR) typing of two microsatellite and one minisatellite regions and also single-nucleotide polymorphism (SNP) typing for nine informative loci.Genotyping showed that the causative strain of M. leprae exhibited a SNP-type 3 profile, characteristic of cases associated geographically with Europe and North Africa. Further SNP sub-typing was performed and the data obtained from the Uzbek leper was compared with the same loci amplified from a case of LL recovered from Blackfriars, Ipswich, UK dating to between the 13th and 16th centuries AD. Unique group 3 subtypes were found in both the Uzbek case and Ipswich 1914. These appear to be ancestral to recent type 3 strains. Mycolic acid analysis confirmed the presence of M. leprae in the Uzbek samples. Phylogenetically informative SNPs and other polymorphic loci will contribute to the study of human migrations, as well as the origin and spread of leprosy.     

Millet cultivation history in the French Alps as evidenced by a sedimentary molecule

We report on the detection, in a sediment core drilled in Lake Le Bourget (French Alps), of a fossil molecule (miliacin) that was synthesized by broomcorn millet cultivated in the watershed, and then exported to the sediment. The variation in abundance of this molecule allows us reconstructing the history of millet cultivation around Lake Le Bourget. Our results support the introduction of millet around −1700 BC in the region. After an intensive cultivation during the Late Bronze Age, the failure of millet cropping during the Hallstatt period coincides with a phase of climatic deterioration. Millet cultivation recovers during the Roman and Mediaeval periods before falling most probably due to the introduction of more productive cereals. These pioneering results constitute the first continuous record of an agrarian activity covering the last 6000 years and emphasize the close relationships between local hydrology, land use and agro-pastoral activities around Lake Le Bourget.     

Nested or exclusive? The role of identities on blame attribution during the Great Recession

Despite an increasing number of studies assessing the importance of institutions as regards to accountability, it still remains to be known whether and how an individual's national and regional identity shapes the attribution of responsibilities in multi‐level settings. By focusing on the economic crisis that affected Europe since 2008, we argue that identity‐based assessments of responsibility for the crisis will occur solely among individuals who hold exclusively national or regional identities and who live in regions that have nationalist aspirations. This will be in contrast to individuals that have exclusively identities who live in regions that lack nationalist aspirations, as well as dual‐identity individuals, irrespective of where they live. We test our arguments by using data from Catalonia and Madrid (Spain) and Bavaria and Lower Saxony (Germany). In line with our expectations, our results show that, in minority nationalist regions such as Catalonia, an individual's identity will crucially determine which level of government is blamed for the economic crisis, while this will not occur in regions with no nationalist aspirations. The article reveals the existence of an additional determinant of blame attribution in some specific multi‐level arrangements and contributes to the understanding of the tensions between identity politics and blame avoidance.     

Irish Republican Politics and Violence before the Peace Process, 1968–1994

Analyses of the Provisional IRA in Northern Ireland tend to underplay the influence of political strategy in the 1970s, preferring to emphasise militarism. Similarly, the persistence of militarism in the 1980s is often obscured by the attention paid to a ‘new’ republican political orientation. This article seeks to draw attention to the IRA's evolving attitude to the ‘problem’ of Ulster unionism, and republicanism's various estimations of the likely efficacy of violence throughout the period. Republicanism is best understood as a deeply rooted working-class ethno-nationalist movement interacting closely with the other agents of the Northern Ireland conflict: constitutional nationalism, unionism and the British government. ‘Armed struggle’ became a declining asset for republicanism as it came to be seen less as a form of ‘popular guerrilla warfare’ and more as ‘terrorism’. 1 [1] For valuable advice, thanks to Prof. Roy Foster. Opinions expressed are my own. View all notes     

Uranium-series dating rock art in East Timor

At many sites throughout the world rock art paintings have been covered by naturally deposited calcite laminations, which we demonstrate can be individually dated by recently improved uranium-series methods. Here we report the application of multi-collector inductively coupled plasma mass spectrometry to measure the ages for carbonate coatings that bracket red pigment at Lene Hara cave, East Timor, which could be evidence of human painting. These analyses establish the feasibility of dating milligram samples of finely layered calcite deposits associated with archaeological evidence of human occupation. In addition to confirming an age of less then 6300 years for the visible red paintings on the carbonate surface we also report a substantially older age of 24,000 to 29,300 years for a similar, older red pigment lamination providing possible evidence for an earlier painting episode.     

Tell Abraq during the second and first millennia BC: site layout,spatial organisation,and economy

Research recommenced at Tell Abraq in 2007, carried out by Bryn Mawr College with an international team in co‐operation with the Sharjah Archaeology Authority. Between 2007 and 2010 fieldwork was limited to documenting sections of the previous excavations and one small sounding while our attention focused mainly on the nearby shell‐midden site of Hamriya and the fortified Iron Age settlement site of Muweilah. Since 2010, large‐scale excavations have been conducted which have fundamentally altered our understanding of the layout of the settlement and its economic relations during the second and first millennia BC. In this report, we detail the results of this work and present preliminary interpretations.     

Policy versus Practice. Behind the Scenes in Dutch Development Aid, 1949–1989

The history of development aid has often been analyzed on the level of international politics and ground breaking ideas on big overriding issues. But the policies developed in the various Western capitals do not in themselves provide a full picture of foreign aid. It is important to examine the field more closely: what did actually happen ‘on the ground’ as a result of intentions and agreements on aid? Did the practice of aid projects influence aid effectiveness? The present article looks at the history of aid provided by the Netherlands, a country that for a long time liked to portray itself as occupying a guiding role in the vanguard of international development. It is based on archival study of project files, set in countries that were at the core of the Dutch aid effort. They are taken from the time span of four decades in which the aid effort was developed and flourished, before the end of the Cold War changed the scenery in 1989. The article aims to shed new light on how policy aims were translated and provides an indication as to why the desired results failed to come about.