Cajal's views on the Nobel Prize for physiology and medicine (October 1904)

In this report we present and discuss an unpublished letter written by Santiago Ramon y Cajal in October 1904 in relation to his possible nomination for the Nobel Prize for Physiology and Medicine. This letter shows that Cajal was aware of his previous nominations for the Prize. He was convinced that these nominations had not been successful because neither anatomy nor histology were among the sciences included in the Nobel Statutes' definition of Physiology or Medicine. He gives a list of the merits he thought might be used for a new nomination, which included only works concluded during the previous five years.     

European influence on Russian neurology in the eighteenth and nineteenth centuries

In this study we consider the development of clinical neurology in the eighteenth and the nineteenth centuries focusing on European influence on Russian medicine. Russian physicians readily accepted newly described clinical signs, theories, and classification of nervous diseases designed in Europe. This influence initiated neurology's separation from general medicine and its transformation into a new clinical discipline. In Russia this happened already in the 1860s, decades before the similar trend in Europe. The Russian example is nearly unknown in the general history of neurology. It illustrates the relationships between physiology and practical neurology at the moment of establishment of the new discipline. It also shows that the Russian physicians of the time readily accepted European medical knowledge putting it immediately into medical practice and education.     

A synthesis of macro and micro approaches to explaining migration: evidence from inter-state migration in the United States

The interrelationships between macro and micro factors in the analysis of interstate migration in the United States are explored. A synthesis between these factors is attempted "by combining objectively calibrated characteristics of states with their subjectively measured counterparts....First, the relationships between the objective variables and their subjective counterparts are analyzed. Second, both sets of variables are used to explain residential preferences and migration. Third, a series of path models are constructed to indicate how the subjective variables act as intervening variables between their objective counterparts and migration."     

Marital instability in a rural population in south-west Uganda: implications for the spread of HIV-1 infection

"The aim of this study was to examine people's beliefs about the causes of marital instability in a rural population cohort in south-west Uganda. Results from a baseline survey of HIV-1 infection in the cohort of over 4,000 adults (over 12 years old) showed a twofold increase in risk of infection in divorced or separated persons when compared with those who are married. A purposive sample of 134 respondents (seventy-two males, sixty-two females) selected to represent different ages, religions and marital status were asked in semi-structured interviews to comment on the reasons for continuing marital instability in their community. The most common reasons suggested for marital instability were sexual dissatisfaction, infertility, alcoholism and mobility....HIV infection was not mentioned as a direct cause of separation, but a small independent study revealed that seven out of ten couples separated on learning of a positive HIV test result of one or both partners. Marital instability is not uncommon in this population; there is evidence that HIV infection is making the situation worse." (SUMMARY IN FRE)     

Animal electricity at the end of the eighteenth century: the many facets of a great scientific controversy

In the 1790s, Luigi Galvani and Alessandro Volta were the main protagonists of a lively debate on the role of electricity in animal organisms. Significant developments originated from this debate, leading to the foundation of two new disciplines, electrodynamics and electrophysiology, that were to play a crucial role in the scientific and technological progress of the last two centuries. The Galvani-Volta controversy has been repeatedly reconstructed, sometimes in an attempt to identify the merits and the errors of one or the other of the two protagonists, sometimes with the aim of demonstrating that the theories elaborated by the two Italian scholars were irreconcilable, reflecting completely different ways of looking at phenomena and conceiving of scientific research. In this article a different interpretation is offered, based on a discussion of the scientific issues that were central to Galvani's and Volta's research, and with reference to the context of science and society of the eighteenth century.     

The Tuskegee Syphilis Study and the scientific concept of racial nervous resistance

In 1932, the U.S. Public Health Service began a study of untreated syphilis among black men in Macon County, Alabama. This project, later known as the Tuskegee Syphilis Study, became one of the most notorious ventures of twentieth-century medicine. Much has been written on it. Historians have suggested that scientific racism strongly influenced the study. But specific links between earlier racial science and the scientific conduct of the study have remained unexplored. The examination in this paper of the concept of a racially determined resistance to syphilis in the nervous system establishes such a link. Discussion of nervous resistance to syphilis appeared in the medical literature in the early twentieth century as a conjecture about the natural inferiority of blacks. White physicians used the concept to interpret racial differences in neurosyphilis as evidence of the rudimentary development of the brain. A small community of African American physicians joined other national experts in syphilis who chose to explain apparent racial differences through alternate mechanisms. But the scientific advisors to the Tuskegee Syphilis Study favored the concept of a racial resistance to neurosyphilis and steered the early design of the study to help to elucidate it. The Tuskegee Syphilis Study was an examination of untreated syphilis, but it also became a demonstration of a putative racial characteristic of syphilis long considered evidence of the natural inferiority of blacks. An examination of the concept of racial nervous resistance and its influence on the research in Macon County helps to define the influence of scientific racism on this notorious medical study.