The Growth Cone as Seen Through Cajal's Original Histological Preparations and Publications

Abstract

Multiple sclerosis (MS) was first presented in a clinical setting in 1838. In this paper the presentation and treatment of a transient hemiparesis in a drummer in 1789 is discussed. This may have been an early case of MS and presents evidence against the theory that MS is an infectious disease beginning in the 19th century.     

Five thousand years of atmospheric Ni,Zn, As,and Cd deposition recorded in bogs from NW Iberia: prehistoric and historic anthropogenic contributions

The analysis of environmental archives from across the world has demonstrated that human perturbation of the geochemical cycles of trace metals and the resultant atmospheric metal contamination date back, at least, several millennia. However, an understanding of the local processes and timing of changes in trace metal deposition is also essential for a proper global interpretation. The Iberian Peninsula was a major mining area since prehistoric times and the analysis of environmental archives provides a good opportunity to improve our understanding of the history of mining and metallurgy in Europe. We present the results from three ¹⁴C dated peat cores from the Xistral Mountains (NW Iberia). These records are used to reconstruct past atmospheric deposition of Ni, Zn, As, and Cd. The chronology of the changes in concentrations and metal accumulation rates was found to be concordant in the three bogs, and showed great similarity to total Pb, Hg, and Pb isotope ratios as determined in previous investigations. They present a consistent view of changes in atmospheric pollution and the importance of metals in the development of human societies, especially: i) the first evidence of atmospheric metal pollution 3400 years ago, which is simultaneous with the expansion of the Atlantic Bronze Koine; ii) a pollution event between 2350 and 2150 years ago, associated to the development of so-called Celtic culture (local Late Iron Age); iii) a dramatic increase of metal fluxes in Roman times; iv) a severe and rapid increase in the last 250 years corresponding to the beginning of the industrial revolution in Europe, reflecting the emergence of the new dominant sources of pollution, and v) the increase of long range atmospheric transport of pollutants. Our data suggest that all detected ancient (until ca. 1450 cal BP) periods of enhanced Ni, Zn, As, and Cd accumulation may have had an anthropogenic origin, related to the onset and development of mining and metallurgy.     

The worm Palaeoscolex from the Cambrian of NW Argentina: extending the biogeography of Cambrian priapulids to South America

Over one hundred years of palaeontological research in northwestern Argentina has provided extensive knowledge of Andean lower Palaeozoic fossil assemblages, with trilobites, graptolites, brachiopods and echinoderms being among the most prominent groups. This record is enriched by the recent discovery of soft-bodied worms in Cambrian outcrops of northwestern Argentina. Palaeoscolex sp. cf. P. ratcliffei from the Furongian Lampazar Formation in Jujuy is described, considerably expanding the biogeographical range of this genus and filling the distributional gap, between the well-known early–middle Cambrian occurrences of Palaeoscolex and those of its Ordovician species.     

Urban geo-archaeology in medieval alzira (Prov. Valencia,Spain)

Alzira is situated in a cut-off meander loop of the Rio Júcar. Geo-archaeological study shows that the Islamic city wall was built during the second quarter of the 11th century AD, at a time when the river had a low-amplitude and low-energy flood regime. After mid-century, overbank silts began to invade the city as peak flood discharge increased, with a spate of destructive floods reflected by high-energy deposits during the late 11th century. Urban expansion within the city wall is dated to the later 11th or early 12th century, interrupted by local abandonment and moderate-energy flood silts. Major construction during the mid-12th century was followed by protracted abandonment (after a siege in AD 1171?) and further, moderate-energy flood silts that redistributed occupation and collapse debris. Reoccupation, during the late 14th century, was terminated by catastrophic floods in 1517 and 1571, after which much of the western end of Alzira was not rebuilt. Following further flood catastrophes during the 17th century, parts of the central walled city remained abandoned until the 19th century. with new occupation atop flood sands of yet another disaster in 1864. The change in flood regime after 1150 was a result of deforestation of the watershed, but progradation of a downstream tributary fan after 1517 created an unstable, aggrading floodplain increasingly prone to severe flooding. Climatic anomalies were responsible for periods of recurrent severe floods, archaeologically verified during the 11th and 12th centuries, and historically documented, beginning in 1318. The geo-archaeological methodology illuminates the constructional and settlement history of Alzira, allows distinction of fluvial and cultural components, and provides the necessary microstratigraphic detail and dating control to document the true complexity of alluvial processes during the last 1000 years.