Magic Bullets for Mental Disorders: The Emergence of the Concept of an “Antipsychotic” Drug

When “antipsychotic” drugs were introduced into psychiatry in the 1950s, they were thought to work by inducing a state of neurological suppression, which reduced behavioral disturbance as well as psychotic symptoms. This view was reflected in the name “neuroleptic.” Within a few years, however, the idea that the drugs were a disease-specific treatment for schizophrenia or psychosis, and that they worked by modifying the underlying pathology of the condition, replaced this earlier view, and they became known as “antipsychotics.” This transformation of views about the drugs' mode of action occurred with little debate or empirical evaluation in the psychiatric literature and obscured earlier evidence about the nature of these drugs. Drug advertisements in the British Journal of Psychiatry reflect the same changes, although the nondisease-specific view persisted for longer. It is suggested that professional interests rather than scientific merit facilitated the rise of the disease-specific view of drug action. The increasing popularity of atypical antipsychotics makes it important to examine the origins of the assumptions on which modern drug treatment is based.     

Birdmen, cemís and duhos: material studies and AMS C dating of Pre-Hispanic Caribbean wood sculptures in the British Museum

This paper presents 19 AMS radiocarbon dates from nine pre-Hispanic Caribbean (Taíno/Lucayan) wooden sculptures in the British Museum collections, provenanced to Jamaica, Hispaniola and the Bahamas. Together with strontium isotope results and wood and resin identifications, these data build a material and chronological context for some of the most recognised examples of Taíno art – from duhos (ceremonial seats) and cemís (free standing depictions of deities, ancestors and spirits) to canopied stands used to hold hallucinogenic drugs during the cohoba ceremony. Each sculpture widens our understanding of Caribbean carving traditions, stylistic variation, chronologies and material resource utilisation. A group of three sculptures recovered from Carpenters Mountains, Jamaica, carved by AD 1300 and brought together as a ceremonial ‘set’, each appear to have had their inlays renewed over a century later, suggesting long-term use. Three key examples of the main Caribbean duho categories (high-back, low-back and extended), provide insights into the diversity of styles present in the region post-AD 1100. The British Museum's corpus enables an exploration of regional styles, and potentially the work of individual artists.     

Investigating perceptions of antisocial behaviour and neighbourhood ethnic heterogeneity in the British Crime Survey

There is much concern in the UK about the effects on community cohesion of antisocial behaviour, but to date relatively little is known about the geography of such behaviour: for what sort of people, and in what sort of places, are high levels of antisocial behaviour a problem? What are the links, if any, between such behaviour and local socio-economic conditions, and how do such perceptions relate to local crime rates? Using data from the British Crime Survey and other secondary datasets, we develop and extend previous work that has investigated links between individual socio-economic characteristics, neighbourhood characteristics and individual perceptions of antisocial behaviour. A multilevel modelling approach is used to ensure that individual- and area-level effects are not conflated. Secondly we extend the substantive knowledge surrounding the relationship between neighbourhood ethnic heterogeneity and individual perceptions of antisocial behaviour. In so doing, we challenge recent contentions that heterogeneity is associated with declining social cohesion and trust. We conclude that at a small-area scale for England, the primary area-level determinants of high levels of antisocial behaviour lie in material circumstances, and that ethnic heterogeneity has no discernible effect on perceptions of antisocial behaviour.     

Teardrops at the Lake: Chemistry of New Kingdom to Makuria Glass Beads and Pendants Between the First and Second Nile Cataracts

International expeditions extensively excavated Lower Nubia (between the First and Second Nile Cataracts) before it was submerged under the waters of Lake Nasser and Lake Nubia. The expeditions concentrated on monumental architecture and cemeteries, including sites at Qustul and Serra East, where the New Kingdom, and Napatan, Meroitic, Nobadian, and Makurian-period elites and common people were buried, ca. 1400 BC–AD 1400. Although the finds abound in adornments, including bead imports from Egypt and South India/Sri Lanka, only a few traces of local glass bead-making have been recorded in Nubia so far. Based on results of laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) analysis of 76 glass beads, pendants, and chunks from Qustul and Serra East contexts, dated between the New Kingdom and the Makuria Kingdom periods, this paper discusses the composition and provenance of two types of plant-ash soda-lime (v-Na-Ca) glass, two types of mineral soda-lime glass (m-Na-Ca), and two types of mineral-soda-high alumina (m-Na-Al) glass. It also presents the remains of a probable local glass bead-making workshop dated to the period of intensive long-distance bead trade in Northeast Africa, AD 400–600.