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Joanna Moncrieff 《Journal of the history of the neurosciences》2013,22(1):30-46
When “antipsychotic” drugs were introduced into psychiatry in the 1950s, they were thought to work by inducing a state of neurological suppression, which reduced behavioral disturbance as well as psychotic symptoms. This view was reflected in the name “neuroleptic.” Within a few years, however, the idea that the drugs were a disease-specific treatment for schizophrenia or psychosis, and that they worked by modifying the underlying pathology of the condition, replaced this earlier view, and they became known as “antipsychotics.” This transformation of views about the drugs' mode of action occurred with little debate or empirical evaluation in the psychiatric literature and obscured earlier evidence about the nature of these drugs. Drug advertisements in the British Journal of Psychiatry reflect the same changes, although the nondisease-specific view persisted for longer. It is suggested that professional interests rather than scientific merit facilitated the rise of the disease-specific view of drug action. The increasing popularity of atypical antipsychotics makes it important to examine the origins of the assumptions on which modern drug treatment is based. 相似文献
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Joanna Ostapkowicz Christopher Bronk Ramsey Fiona Brock Caroline Cartwright Rebecca Stacey Mike Richards 《Journal of archaeological science》2013
This paper presents 19 AMS radiocarbon dates from nine pre-Hispanic Caribbean (Taíno/Lucayan) wooden sculptures in the British Museum collections, provenanced to Jamaica, Hispaniola and the Bahamas. Together with strontium isotope results and wood and resin identifications, these data build a material and chronological context for some of the most recognised examples of Taíno art – from duhos (ceremonial seats) and cemís (free standing depictions of deities, ancestors and spirits) to canopied stands used to hold hallucinogenic drugs during the cohoba ceremony. Each sculpture widens our understanding of Caribbean carving traditions, stylistic variation, chronologies and material resource utilisation. A group of three sculptures recovered from Carpenters Mountains, Jamaica, carved by AD 1300 and brought together as a ceremonial ‘set’, each appear to have had their inlays renewed over a century later, suggesting long-term use. Three key examples of the main Caribbean duho categories (high-back, low-back and extended), provide insights into the diversity of styles present in the region post-AD 1100. The British Museum's corpus enables an exploration of regional styles, and potentially the work of individual artists. 相似文献
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Sermo Doctorum: Compilers,Preachers, and their Audiences in the Early Medieval West. Edited by Maximilian Diesenberger,Yitzhak Hen and Marianne Pollheimer. Sermo: Studies on Patristic,Medieval, and Reformation Sermons and Preaching 9. Turnhout: Brepols. 2013. ix + 452 pp. + 2 b/w figures + 5 b/w tables. €110. ISBN 978 2 503 53515 9. 下载免费PDF全文
Joanna Thornborough 《Early Medieval Europe》2017,25(2):228-231
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Joanna Taylor Liz Twigg John Mohan 《Transactions (Institute of British Geographers : 1965)》2010,35(1):59-75
There is much concern in the UK about the effects on community cohesion of antisocial behaviour, but to date relatively little is known about the geography of such behaviour: for what sort of people, and in what sort of places, are high levels of antisocial behaviour a problem? What are the links, if any, between such behaviour and local socio-economic conditions, and how do such perceptions relate to local crime rates? Using data from the British Crime Survey and other secondary datasets, we develop and extend previous work that has investigated links between individual socio-economic characteristics, neighbourhood characteristics and individual perceptions of antisocial behaviour. A multilevel modelling approach is used to ensure that individual- and area-level effects are not conflated. Secondly we extend the substantive knowledge surrounding the relationship between neighbourhood ethnic heterogeneity and individual perceptions of antisocial behaviour. In so doing, we challenge recent contentions that heterogeneity is associated with declining social cohesion and trust. We conclude that at a small-area scale for England, the primary area-level determinants of high levels of antisocial behaviour lie in material circumstances, and that ethnic heterogeneity has no discernible effect on perceptions of antisocial behaviour. 相似文献