Charcot-Marie-Tooth disease from first description to genetic localization of mutations

Charcot-Marie-Tooth disease is a hereditary motor and sensory neuropathy first described in 1886. Our increasing knowledge of this disease correlates well with the development of methods used in neurology over the past 100 years. Although its physiopathology and treatment is still not fully understood, current developments in techniques are opening the way to future discoveries. We have divided its history into three theoretical periods: the first from 1886 to 1956, which was devoted to clinical and pathological study of the disease; the second from 1956 to 1982, which saw the development of electromyography in the investigation of neuromuscular diseases; and the last and current period based upon genetic research, using the methods of molecular biology.     

Neutron activation analysis of stone from the Chadron Formation and a Clovis Site on the Great Plains

Cryptocrystalline silicates from the Chadron Formation were widely used by prehistoric human groups in the Great Plains of North America. There are two documented quarry areas: Flattop Butte in Colorado and the White River Badlands of South Dakota. Cryptocrystalline silicates from these sources are visually indistinguishable, making it difficult to determine the sources of artefacts found at archaeological sites. In this investigation, neutron activation analysis is used to distinguish the two sources. This technique also identifies lithic material from the Clovis-age Eckles site in Kansas as being from Flattop Butte.     

CORPORATE IDEOLOGY AND THE POLITICS OF ENTREPRENEURISM IN NEW ORLEANS

In this article, Louis F. Miron presents a case study of the effects of local ideology and culture on corporate-lead progrowth movements in New Orleans. Miron borrows from critical theory to illustrate how "hegemonic" ideologies such as economic growth may be resisted in local settings. The findings suggest that economic structural relations do not predetermine the course of human agency, and that the success of progrowth movements is contingent upon local cultural conditions and ethos. Through a document analysis of "fiscal reform," a pro-growth ideology advanced by corporate and political elites in New Orleans and throughout Louisiana, the author probes the connections among material conditions, ideology, and the politics of entrepreneurism.     

ANALYSIS OF THEORETICAL,METHODOLOGICAL AND EMPIRICAL RESEARCH IN THE JOURNAL OF REGIONAL SCIENCE*

ABSTRACT. This paper examines the impacts of JRS articles in the areas of theory, methods and empirical analysis, as represented by subsequent citations reported in the Social Sciences Citation Index. A model relating the mix of theoretical, methodological and empirical research published in the JRS to subsequent citations is estimated. The time distribution of theoretical and empirical citations also indicates that the knowledge diffusion process in these two areas may be segmented.     

Heterodoxe lehren und ihre widerlegung im Kālacakra-tantra

Summary At the end of the second chapter of the Buddhist Klacakra-Tantra (dated c. 10th century) we find a group of verses in which several doctrines are characterized and criticized: Brahmanism, Vaisnavism, aivism, materialism, Islam and Jainism. Moreover the text refers to Buddhism itself as well as the so-called heterodox Buddhist schools. It is the only old Sanskrit text known until now in which the Islam is mentioned and recognized as a doctrine.