Making the Brain Plastic: Early Neuroanatomical Staining Techniques and the Pursuit of Structural Plasticity, 1910–1970

The concept of neuronal plasticity is widely used, but seldom defined in the neurosciences. It can signify many different occurrences, such as structural alterations of axons and dendrites (Cotman & Nadler, 1978), behavioural adaptations (Rosenzweig & Bennett, 1996), or physiological changes in synapse formation (Martin et al., 2000) at different stages of health and disease. Although there is such a wealth of research from many disciplines, the neuroanatomical aspects of plasticity are the focus of this paper. It seeks to illuminate the evolution of different concepts of plasticity concerning the structure and circuitry of the central nervous system (CNS). Early modern morphological research on de- and regeneration phenomena in the 19th- and early 20th-century is well documented. These studies, however, almost exclusively concentrated on the peripheral nervous system (PNS). It was one of the major contributions of Santiago Ramón y Cajal (1852–1934), that he applied the concept of regenerative capacities to the CNS. But the term plasticity seemed to have disappeared for about two decades after his death. The ensuing comeback of the expression may be attributed, at least in part, to new neuroanatomical staining and tracing methods. The pursuit of these techniques will serve as a guidepost through varying approaches in different times: It was the 1950s which seemed to spawn the time for new departures in structural investigations of neuronal plasticity.     

The royal society: National committee for geography

The Geomorphology of the British Isles series: Ireland. By G. L. H. Davies and N. Stephens. 21 × 14, 250 pp. Methuen, 1978. £7.95.

Causes of Climate by J. G. Lockwood. 24 × 16, 10 + 260 pp. 22 photos, 102 diagrams, 34 tables, index (to text only), glossary. Edward Arnold, 1979. £5.95.

Humanistic Geography: Prospects and Problems. Edited by David Ley and Marwyn Samuels, i‐viii. 23 × 16, 337 pp. Croom Helm, London, 1978. £11.95.

South America. By Arthur Morris. 25 × 19, 271 pp., 59 maps and diagrams, 43 plates, appendices, bibliography, index. Hodder and Stoughton, London, 1979. Paper, £5.45.

The Fur Trade of the American West, 1807–1840. By D. J. Wishart. 22.5 x 14.5, 237 pp. Illustrations, references, bibliography, index. Croom Helm, London, 1979. £12.95.

Outlook Geography: Worldscapes. A. Ayres et al. 25 × 19, 136 pp. Oliver and Boyd, Edinburgh, 1978. £2.45.

The Changing Geography of Britain. By W. E. Marsden. 25 × 19, 196 pp. Oliver and Boyd, Edinburgh, 1978. £2.50.     

Inferences for Selected Location Quotients with Applications to Health Outcomes. 选择性区位商推断及其在医疗成效中的应用

The location quotient (LQ) is an index frequently used in geography and economics to measure the relative concentration of activities. This quotient is calculated in a variety of ways depending on which group is used as a reference. Here, we focus on a simultaneous inference for the ratios of the individual proportions to the overall proportion based on binomial data. This is a multiple comparison problem and inferences for LQs with adjustments for multiplicity have not been addressed before. The comparisons are negatively correlated. The quotients can be simultaneously tested against unity, and simultaneous confidence intervals can be constructed for the LQs based on existing probability inequalities and by directly using the asymptotic joint distribution of the associated test statistics. The proposed inferences are appropriate for analysis based on sample surveys. Two real data sets are used to demonstrate the application of multiplicity‐adjusted LQs. A simulation study is also carried out to assess the performance of the proposed methods to achieve a nominal coverage probability. For the LQs considered, the coverage of the simple Bonferroni‐adjusted Fieller intervals for LQs is observed to be almost as good as the coverage of the method that directly takes the correlations into account.     

Performance of different luminescence approaches for the dating of known-age glaciofluvial deposits from northern Switzerland

Luminescence properties of two samples taken from sand lenses in proglacial outwash de-posits of a piedmont glacier that reached the Swiss midlands during the Last Glacial Maximum are investigated in detail. Deconvolution of CW-OSL decay curves shows that the fast component dominates the OSL signal of quartz. The chemistry of single feldspar grains, in particular the K content in different grains, is determined using wavelength dispersive spectrometry (electron microprobe), revealing an average 12.9 wt.% K of the grains contributing to the IRSL signal. D _e distributions are investigated in order to gain insights into partial bleaching, and agreement is found for quartz OSL and feldspar IR₅₀ and pIRIR₂₂₅ ages for small aliquots and single grains when applying the Minimum Age Model. These ages are also consistent with independent age control. For one sample, ages determined using the Central Age Model result in highly overestimated ages for both feldspar and quartz.     

The general will beyond Rousseau: Sieyès’ theological arguments for the sovereignty of the Revolutionary National Assembly

Cultural history's recent treatments of Sieyès’ political theory have understood his political writings in their convergences with and divergences from Rousseau's political theory. By sketching a thoroughgoing analogy between the ecclesiological arguments in Malebranche's Entretiens sur la Métaphysique et sur la Religion (1688) and the arguments that Sieyès offers on the floor of the National Assembly concerning the nature of representation, I suggest that we should recontextualize Sieyès’ speeches vis-à-vis the broader discourse of the ‘general will,’ which was theological at its root. That is, the arguments Sieyès offers for the sovereignty of the National Assembly, separately and in combination, appear to have been shaped by a malebranchiste ecclesiology that grew out of the particular context of the Jansenist challenge to the Church. This argument has ramifications not just for our understanding of Sieyès and revolutionary political theory but also for what have been called the “religious origins of the French Revolution.”     

Female domestic servants as desirable refugees: gender, labour needs and immigration policy in Belgium, The Netherlands and Great Britain

The immigration policies adopted by Western European states during the interwar period were marked by increasing restriction, especially after 1933. One notable exception to this was the relatively generous treatment afforded to women who were prepared to take up employment as domestic servants. This article looks at the reasons behind this anomaly and compares the responses of three states that were in the front line of the refugee efflux from Germany and Eastern Europe in the years leading up to the Second World War.