Historical Development of the Dopamine Hypothesis of Schizophrenia

This review examines the history of discoveries that contributed to development of the dopamine hypothesis of schizophrenia. The origin of the hypothesis is traced to the recognition that neuroleptic drugs interfere with brain dopamine function. This insight was derived from two distinct lines of research. The first line originated from the discovery in 1956 that reserpine depletes brain serotonin. This finding resulted in a sequence of studies that led to the discovery that brain dopamine is involved in neuroleptic-induced extrapyramidal motor disturbances. The second line of research was aimed at determining the mechanism of action of psychomotor stimulants. This research produced evidence that stimulants directly or indirectly activate brain dopamine receptors. Because nonreserpine neuroleptics such as chlorpromazine block stimulant-induced movement, these findings suggested that neuroleptics were dopamine antagonists. Most previous accounts of the development of the dopamine hypothesis of schizophrenia emphasize the first line of research and ignore the second.     

Communication of Discoveries of Medieval Paintings,Etc

Abstract

Until 1965 Holy Trinity parish church, Much Wenlock (Shropshire), was believed to be wholly Norman and later. In that year it was proposed that the south chancel chapel and south nave aisle were Anglo-Saxon. Two vertical strips of squared stones, built into the upper part (a later heightening) of the aisle's south wall, were interpreted as Anglo-Saxon pilaster strips of the type later classified by Dr H. M. Taylor as ‘long-and-short’. If the upper part of that wall was Anglo-Saxon, the lower part must have been earlier Anglo-Saxon, and so must the chapel south wall, which is integral with the lower part of the aisle wall. The Norman nave and chancel must have been added to an-existing Anglo-Saxon structure.

We believe, however, that the aisle and chapel must have been added to an existing Norman structure, for the Norman nave had originally a south-east external clasping buttress. Structural and documentary evidence shows that the strips are probably of the later thirteenth or earlier fourteenth century. Moreover similar strips occur in another part of the church that is probably of that date or later. ‘Pilaster strips’ of ‘long-and-short’ appearance may evidently be looked for elsewhere in twelfth-century or later contexts, especially in the heightened parts of unsupported rubble walls.     

The British Archaeological Association Honorary Secretary’s Report For 1939

Abstract

In the Lady chapel at the east end of the north aisle of the church at Pucklechurch (Gloucestershire) are two effigial monuments, which have received little scholarly attention. The monuments are attributed to William de Cheltenham (d. between 1371 and 1374) and his wife Eleanor, and were set up in his lifetime within the chantry chapel dedicated to St Mary which William received licence to establish at Pucklechurch in 1337. Little remains of the chapel except an exquisite altar frontal. During the 19th century the two effigies were transposed. Various aspects of the conception and design of the Pucklechurch monuments reflect developments in monumental sculpture in Herefordshire.     

The Oldest Culture-Circles in Asia

The following essay is divided into three parts. In the first part, evidences are presented to show that, as a result of modern etymological researches, the traditional interpretation of as “what a man becomes after his death” can no longer be accepted as representing the primitive meaning of this character. In the second part, further evidences, both documentary and palaeographic, are adduced to show that was very probably the name given to some simian or anthropoid animal; and that its current significations of ghost, sprite, devil, etc. are but later modifications of this primitive notion. In the last part, the author makes a tentative classification of characters and terms which are the graphic, semantic or phonetic cognates of in the light of the above conclusions.