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101.
102.
There is much concern in the UK about the effects on community cohesion of antisocial behaviour, but to date relatively little is known about the geography of such behaviour: for what sort of people, and in what sort of places, are high levels of antisocial behaviour a problem? What are the links, if any, between such behaviour and local socio-economic conditions, and how do such perceptions relate to local crime rates? Using data from the British Crime Survey and other secondary datasets, we develop and extend previous work that has investigated links between individual socio-economic characteristics, neighbourhood characteristics and individual perceptions of antisocial behaviour. A multilevel modelling approach is used to ensure that individual- and area-level effects are not conflated. Secondly we extend the substantive knowledge surrounding the relationship between neighbourhood ethnic heterogeneity and individual perceptions of antisocial behaviour. In so doing, we challenge recent contentions that heterogeneity is associated with declining social cohesion and trust. We conclude that at a small-area scale for England, the primary area-level determinants of high levels of antisocial behaviour lie in material circumstances, and that ethnic heterogeneity has no discernible effect on perceptions of antisocial behaviour.  相似文献   
103.
Using ancient DNA methods, we have examined in detail two archaeological cases of leprosy from Mediaeval England. The first was a child skeleton with rhino-maxillary changes typical of lepromatous leprosy (LL). The second case was the skeleton of a male adult who showed both typical rhino-maxillary changes and osteitis/periostitis on the leg and foot bones. Bone powder was sampled from both cases and DNA extracts were prepared. These were subjected to a series of polymerase chain reactions (PCRs) specific for regions on the Mycobacterium leprae genome. The repetitive element RLEP was used for confirmation of M. leprae DNA and then three polymorphic regions were successfully amplified and sequenced to determine the number of variable nucleotide tandem repeats (vntr) at these loci. These were the microsatellite regions ML2344 and ML2172 and the minisatellite region ML0058. Genotyping data from the strains preserved within the skeletal remains were compared with those obtained for a reference strain of M. leprae. Variation at these three loci was found between both burials and the reference strain, indicating that vntr typing of LL cases from the archaeological record is a useful way of confirming disease and an additional means of authenticating aDNA data. This demonstrates the feasibility of targeting multiple loci for phylogenetic studies of leprosy strains from archival sources.  相似文献   
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This article provides a framework for the evaluation of West Edmonton Mall within the broader context of the national regional shopping centre system. A particular focus is placed on the tenant mix and functional structure for those 37 shopping centres with a minimum gross leasable area of 750 000 sq. ft The analysis illustrates the similarity in the degree of chaining and corporate ownership in these major shopping facilities and describes their structural characteristics. The article concludes by evaluating both the development of the mega-mall phenomenon and speculates about the future position of these malls in the retail system.  相似文献   
106.
Identifying and removing access barriers to the timely provision of comprehensive health care is increasingly important for the wellbeing of Australia's rapidly ageing and frail populations, particularly those in non‐metropolitan settings. This study has examined if current general practice (GP) locations in non‐metropolitan South Australia (SA) and Western Australia (WA) are geographically accessible to the rapidly growing frail and prefrail populations known to have a high level of health service use and reduced mobility. Geospatial analysis linking 60‐kilometre GP service catchments, 2016 population counts, and 2027 population projections has estimated that the size of the frail and prefrail population that live outside these GP service catchments will double, reaching 7,800 people by 2027. The maldistribution of GP locations was most evident in WA. As regional and remote populations continue to age, the challenge of health service provision, including geographic access to care, must be resolved to ensure that populations in these areas have the best opportunity to age well. Geospatial methods linking service and demographic information, such as the approach used in this analysis, can aid in planning the equitable provision of health care for older Australians.  相似文献   
107.
While much attention has been paid to the ways in which the private sector is now embedded within the field of development, one group of actors — for-profit development consultancies and contractors, or service providers — has received relatively little attention. This article analyses the growing role of for-profit consultancies and contractors in British aid delivery, which has been driven by two key trends: first, the outsourcing of managerial, audit and knowledge-management functions as part of efforts to bring private sector approaches and skills into public spending on aid; and second, the reconfiguration of aid spending towards markets and the private sector, and away from locally embedded, state-focused aid programming. The authors argue that both trends were launched under New Labour in the early 2000s, and super-charged under successive Conservative governments. The resulting entanglement means that the policies and practices of the UK government's aid agencies, and the interests and forms of for-profit service providers, are increasingly mutually constitutive. Amongst other implications, this shift acts to displace traditional forms of contestation and accountability of aid delivery.  相似文献   
108.
The Church of the Holy Apostles was one of the most important buildings in Byzantine Constantinople. The mausolea of Constantine the Great (the main imperial burial place until the eleventh century) and of Justinian I were in the complex surrounding this vast cruciform church. Nothing of this complex appeared to have survived its demolition to clear the site of the Ottoman mosque complex of Fatih Camii after 1461. Fieldwork in 2001 recorded walls pre–dating the fifteenth–century phase of the mosque complex, still standing above ground level and apparently including a large rectilinear structure. This is identified as the Church of the Holy Apostles and an adjacent enclosure may be that containing the mausoleum of Constantine the Great. The reconstructed church plan resembles those of St John of Ephesus and St Mark's (San Marco), Venice – churches known to have been modelled on the Church of the Holy Apostles, Constantinople.  相似文献   
109.
Erosion in the 1960s resulted in exposure of human skeletal remains from a Norse Christian cemetery at Newark Bay, Orkney, Scotland. One set of remains showed osteological evidence of advanced lepromatous leprosy, but the absence of bones from the lower limbs precluded definitive diagnosis. The aim of the present study was to determine whether Mycobacterium leprae could be detected in bone extracts, as a means of confirming the diagnosis of leprosy. Bone samples were examined from the suspected leprosy case and from a second contemporary burial thought to be free of disease. DNA was amplified by polymerase chain reaction (PCR) using primers specific for a repetitive element (RLEP) characteristic of M. leprae. Additional PCR tests specific for Mycobacterium tuberculosis and for amelogenin (a human gene suitable for sex determination) were also applied to the samples. M. leprae DNA was detected only in the skull sample from the suspected leprosy case. The DNA sequence was identical to that found in present day isolates of M. leprae. Positive results were obtained only using a PCR reaction designed to amplify relatively short stretches of DNA (<175 bp), suggesting the microbial DNA had undergone extensive fragmentation. There was no evidence of M. tuberculosis DNA in bones from the leprosy suspect or control individual. The ability to recover ancient samples of DNA provides an opportunity to study long-term evolutionary changes that may affect the epidemiology of microbial pathogens.  相似文献   
110.
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