Molecular identification and characterization of Mycobacterium tuberculosis complex in ancient Egyptian mummies

A considerable number of molecular studies have provided evidence for the presence of Mycobacterium tuberculosis complex (MTB) DNA in ancient skeletal and mummified material. Moreover first studies on the differentiation of sub‐types of the MTB (M. tuberculosis, M. bovis, M. africanum, M. microti, M. canettii) have successfully been performed on ancient tissue samples. In our present study we extend previous analyses and investigate bone and soft tissue samples from 118 ancient Egyptian mummies and skeletons from the Pre‐ to Early Dynastic site of Abydos and different tomb complexes in Thebes West, which were built and used between the Middle and New Kingdom until the Late Period (c. 2050–500 BC). The samples were tested for the presence of MTB DNA and further identified by spoligotyping. Twenty‐six samples provided molecular evidence for the presence of ancient mycobacterial DNA by amplification of a 123 base pair fragment of the repetitive element IS6110. Out of the 26 positive samples, 12 provided a complete spoligotyping signature, which was compared to an international database. Ten further cases showed an incomplete, patchy hybridization pattern, while in four cases no spoligotyping signature could be obtained. Interestingly, they all show either a M. tuberculosis or M. africanum pattern, but none revealed a M. bovis specific pattern. In the material from a Middle Kingdom tomb (used exclusively between c. 2050–1650 BC) several samples revealed a M. africanum type specific spoligotyping signature, while samples from later periods provided patterns typical for M. tuberculosis. This study clearly shows that spoligotyping can be used for the characterization of members of the MTB in historic tissue samples. In addition, our results do not support the theory that M. tuberculosis originated from the M. bovis type. Copyright © 2004 John Wiley & Sons, Ltd.     

Daughters,Decisions and Domination: An Empirical and Conceptual Critique of Household Strategies

This article focuses upon the decision-making process in the household with regard to young women and factory employment in Java and Taiwan, and critically examines to what extent these processes reflect household strategies. While Javanese daughters may seek factory employment against parents' wishes, Taiwanese daughters may be obliged to submit to parental decisions and work for years in order to contribute income. The concept of ‘household strategies’, however, inadequately describes both situations, masking relations of power, resistance and inequality within the household. The assumptions underlying the concept of household strategies and their broader analytical implications are explored, leading to the conclusion that a more differentiated view of the household is needed, taking power relations and struggles between genders and generations into account.     

The Right to Rule by Thumb: A Comment on Epistemology in “A Route Map for Successful Applications of Geographically-Weighted Regression”

Comber et al. provide an important contribution to the future of quantitative geography and Geographical Analysis. The contribution is chiefly in their development of a “GWR Route Map,” a diagram showing the sequence of analytical steps that “successful” specification searches in local modeling tend to follow. Geographically weighted techniques have been rapidly expanding, both in terms of complexity, users, and disciplinary reach. With geographically weighted methods now in so many more analysts' hands, any new rule of thumb will have a major imprint. But, by what right does the thumb rule the analysts? That is, what “counts” as valid knowledge about local models in general? In the following comment, I argue that we probably should use theory, not route maps to decide specifications. But, if we are pressed to build route maps, we sorely need better epistemological foundations for them. I discuss a few previous examples of strongly grounded route maps and offer a few paths to these better grounds as well as two ways to the exit.     

Crises and policy responses within the political trilemma: Europe, 1929–36 and 2008–11

The recent debate on the Eurozone failed to appreciate a particular characteristic of European crisis experiences, namely their fundamentally political character. To make my argument, I borrow from Dani Rodrik (2000) the framework of a “political trilemma” between cross-border economic integration, national institutions and democracy (in the sense of mass politics) and discuss its relation to the more commonly known “macroeconomic trilemma” as well as some limitations of the framework. The recent experience of a European debt crisis and the experience of Europe's Great Depression can be interpreted as a “political trilemma”: both reflect the problem of designing effective policy responses to major economic shocks within the environment of deep economic integration across political boundaries and the regime choices that this involves. Within this framework I highlight some aspects of the 1930s that are informative to the policy choices in Europe today. Once we accept that some policy choices should be avoided, attention should be shifted to the remaining options and the obstacles that prevent their implementation, notably the challenge to transform democracy beyond national borders.     

Is it really bridging the gap? Fiber internet's impact on housing values and homebuyer demographics

Fiber internet expansion represents a path to improved economic vitality for Americans, but it is unclear who benefits from it and by how much. We examine the effects of subsidized fiber internet expansion on home prices and homebuyer demographics using data from Wisconsin and an IV approach to correct for fiber network endogeneity. We find fiber internet increases urban and rural housing values by 1.83% ($3,462) and decreases the likelihood a homebuyer is white by 2.88%, but in urban areas only. Fiber internet therefore does not appear to drive minority homebuyers away but may contribute to the urban-rural racial divide.