The search for a precise method of measurement in psychical experiments

Presents three brief case studies to show how cognition and psychic activity were explored as energetic and economic transactions in a variety of experimental settings. First, in the 1870's German psychiatrist Emil Kraepelin began a search for an objective measurement of cognitive performance in which he engaged for several decades. His investigations resulted in a graphic representation of cognitive efficiency, the Arbeitscurve, delineating numbers of additions per time interval in close resemblance to representations of machine efficiency. Second, at the turn of the century American nutrition scientist and agronomist Wilbur Olin Atwater convinced himself in a series of precision measurements that the human motor was a perfectly closed input-output system and that any mental surplus in the form of cognitive energy transformation did not count as contradictions to the principle of the conservation of energy. Third, at the beginning of the 20th century and on the basis of Atwater's results, German psychiatrist Hans Berger stipulated a special form of psychic energy for mediating between the principle of the conservation of energy and mental causality. Berger attempted to quantify psychic energy as one factor of brain metabolism. In the three cases of precision investigations into psychic life presented here, the experimental space of psychophysiology turned mental activity into a form of machine-like behavior.     

The correspondence of Johann Bartholomäus Trommsdorff (1770-1837): more then a source book of pharmaceutical history

The aim of this paper is to present the publication of the correspondence of Johann Bartholom?us Trommsdorff (1770 bis 1837) and to inform about the history of this project as well as the methodical proceedings and the content of these letters. The opportunities and limitations of the modern Trommsdorff research, based on the publication of his correspondence, will be shown. His contacts have been manifold and expansive. He corresponded with many famous scientists in pharmacy, chemistry, medicine and with important people of intellectual origin. Trommsdorff was a highly important person of the international European relationships in the field of pharmacy. Many publications certify the importance of the Trommsdorff-correspondence. The publication of these letters has opened new biographical aspects and allows to follow the connections and ways of communication in the new age of the foundation of scientific pharmacy.     

Friedrich Heinrich Lewy (1885-1950) and his work

In 1912, Friedrich Heinrich Lewy first described the inclusion bodies named after him and seen in paralysis agitans (p.a.). Tretiakoff had found (1919) that the nucleus niger is most likely to be affected but in a subsequent large-scale series of post-mortem examinations (1923). Lewy was able to confirm this for a minority of cases only, with the exception of those that displayed postencephalitic Parkinsonism (and an unknown number of atypical Parkinson syndrome cases not identified until the 1960s). In a speculative paper (1932), he saw similarities between inclusion bodies in p.a. and viral diseases like lyssa and postulated a viral genesis of p.a. In a historical review of basal ganglia diseases (1942), he did not mention the putative significance of the inclusion bodies for the post-mortem diagnosis. It seems that their importance was seen only after Lewy's death, long after Tretiakoff's initial naming of the 'corps de Lewy'. Lewy, however, had already described their diffuse and cortical distribution (1923). An identification of diffuse Lewy body disease or dementia followed much later. Lewy's career in many diverse branches of neurology and internal medicine was strongly affected by World War I and the difficult situation faced by Jews in Germany. Shortly after the Neurological Institute was founded in Berlin in 1932 (as a clinic and research institute), he was forced, in 1933, to emigrate. His exile in England and the United States mirrors the fate of many German Jews and academics in the first half of the 20th century.