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The smart specialization literature has hardly addressed the role of geography in promoting novel approaches to local and regional innovation processes beyond classic clustering approaches. Based on empirical observations from five sparsely populated regions, the present article proposes original insights that contribute to the theoretical debate on the place-based nature and spatial dimension of entrepreneurial discovery, the key functional mechanism behind smart specialization. First, it advocates the added-value of integrating strategic spatial planning approaches at different stages of smart specialization implementation, from design to operationalization. Second, it suggests that more effective ways of creating domains through shared knowledge bases of existing sectors should aim at promoting collaboration between second-tier economic agents. Finally, the specificity of the territorial preconditions found in sparsely populated regions brings to the fore new forms of proximity relations based on institutional, cognitive and organizational proximity rather than on geographical clustering.  相似文献   
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A human femur diaphysis in the form of a burin was excavated from a secondary burial context containing osteological remains and industry in the Archaeological Complex of Perdigões (Portugal). The majority of these evidences are thermo‐altered and highly fragmented. Radiocarbon dates for this context place it in the middle 3rd millennium BC. Typological analyses indicate that the human femur fragment is a burin, and use‐wear comparisons suggest that it was used to drill hide. Copyright © 2016 John Wiley & Sons, Ltd.  相似文献   
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This paper discusses Amazonian agricultural development with emphasis on the interrelations between regional conditions and the economic context represented by the national economy. The extreme abundance of land relative to complementary factors, together with the position of the region as a price taker in both factor and output markets, create the conditions for environmentally destructive expansion of cultivation at the extensive margin. It is argued that policies to promote a more ecologically sensitive pattern of development must take into account these links with the larger Brazilian economy and society as well as conditions within the region itself.  相似文献   
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For the last ten years, within molecular life sciences, the reproducibility crisis discourse has been embodied as a crisis of trust in scientific images. Beyond the contentious perception of “questionable research practices” associated with a digital turn in the production of images, this paper highlights the transformations of gel electrophoresis as a family of experimental techniques. Our aim is to analyze the evolving epistemic status of generated images and its connection with a crisis of trust in images within that field. From the 1980s to the 2000s, we identify two key innovations (precast gels and gel docs) leading to a “two-tiered” gel electrophoresis with different standardization procedures, different epistemic statuses of the produced images and different ways of generating (dis)trust in images. The first tier, exemplified by differential gel electrophoresis (DIGE), is characterized by specialized devices processing images as quantitative data. The second tier, exemplified by polyacrylamide gel electrophoresis (PAGE), is described as a routine technique making use of image as qualitative “virtual witnessing.” The difference between these two tiers is particularly apparent in the ways images are processed, even though both tiers involve image digitization. Our account thus highlights different views on reproducibility within the two tiers. Comparability of images is insisted upon in the first tier while traceability is expected in the second tier. It is striking that these differences occur not only within the same scientific field, but even within the same family of experimental techniques. In the second tier, digitization entails distrust, whereas it implies a collective sentiment of trust in the first tier.  相似文献   
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