Historical development of the dopamine hypothesis of schizophrenia

This review examines the history of discoveries that contributed to development of the dopamine hypothesis of schizophrenia. The origin of the hypothesis is traced to the recognition that neuroleptic drugs interfere with brain dopamine function. This insight was derived from two distinct lines of research. The first line originated from the discovery in 1956 that reserpine depletes brain serotonin. This finding resulted in a sequence of studies that led to the discovery that brain dopamine is involved in neuroleptic-induced extrapyramidal motor disturbances. The second line of research was aimed at determining the mechanism of action of psychomotor stimulants. This research produced evidence that stimulants directly or indirectly activate brain dopamine receptors. Because nonreserpine neuroleptics such as chlorpromazine block stimulant-induced movement, these findings suggested that neuroleptics were dopamine antagonists. Most previous accounts of the development of the dopamine hypothesis of schizophrenia emphasize the first line of research and ignore the second.     

Gaining a “sense of place”: students’ affective experiences of place leading to transformative learning on international fieldwork

This paper reveals the extent to which undergraduate students demonstrate transformative learning whilst on international fieldwork in Barcelona, Spain. Groups of students create a series of discrete active learning situations that allow them and their peers to engage more fully with their locale and in turn experience a deeper understanding of “place”. Reflective field trip notebooks are used to capture the experiences of students. Results show that through the use of the affective domain (Krathwohl’s taxonomy) and applying cyclic experiential learning (Kolb) combined with critical reflection (Mezirow), students demonstrate progression and, in some cases, regression along Krathwohl’s taxonomy.     

Tourism planning and place making: place-making or placemaking?

ABSTRACT

Tourism destination planning and marketing are fundamentally place making actions intended to shape the image and imageability of a place. Place making is an innate human behavior, ranging from the organic and unplanned actions of individuals, defined here as ‘place-making,’ to planned and intentional global theming by governments and tourism authorities, defined here as ‘placemaking.’ Place-making and placemaking are ends on a continuum of options, with most places have a mix of local and global elements. These elements also range from the tangible (base in urban design) to the intangible (peoplescapes and imaginations). The tools of place making are essentially the same for both organic place-making and planned placemaking, but the intentions and outcomes can vary enormously. Tourism development, as an economic activity, almost always has a neoliberal planned placemaking agenda. Organic place-making emerges through individual agency, which if allowed to proceed, will make its imprint even in a heavily master planned tourism landscape. An understanding of place-making and placemaking gives insight into research questions on the political economy of tourism and the roles of hosts and guest in co-producing tourism places. Examining the elements of place making in a tourism landscape can more clearly identify how different worldview perspectives have contribute over time to the making of tourism places, and thereby assist in planning for the future development of destination communities.     

Perceptions of trekking tourism and social and environmental change in Nepal's Himalayas

The Himalayas are among the world's youngest mountain ranges. In addition to the geologic processes of mountain building and erosion, they are also highly vulnerable to human influenced change, occurring at local, national, regional, and international scales. A photo-elicitation methodology is employed to show how residents perceive those changes from historical perspectives, as well as their current conditions and impacts on their daily lives. Nepal's Khumbu region has undergone major social and environmental transformations since the 1960s when international trekking first began to influence the area's economy. The current perceptions of Khumbu residents of these changes are assessed through photo-elicitation interviews. Their responses are placed in the historical context of: (1) institutional and political changes, most of which have been driven by national government policies; (2) social and economic changes, for which the tourism economy has been central; and (3) environmental changes, reflecting the impacts of resource management and climate change. The mostly positive perceptions of Khumbu residents toward how their region has changed reflects general improvements in the physical and cultural landscapes of the Khumbu over time, as well as its continuing geographic isolation, which has helped to slow the rate of globalization, while also keeping the region a dynamic and popular tourist destination.     

TOCQUEVILLE AND THE FRENCH REVOLUTION

Tocqueville Unveiled : The Historian and His Sources for The Old Regime and the Revolution . By Robert T. Gannett Jr.