Historical development of the dopamine hypothesis of schizophrenia

This review examines the history of discoveries that contributed to development of the dopamine hypothesis of schizophrenia. The origin of the hypothesis is traced to the recognition that neuroleptic drugs interfere with brain dopamine function. This insight was derived from two distinct lines of research. The first line originated from the discovery in 1956 that reserpine depletes brain serotonin. This finding resulted in a sequence of studies that led to the discovery that brain dopamine is involved in neuroleptic-induced extrapyramidal motor disturbances. The second line of research was aimed at determining the mechanism of action of psychomotor stimulants. This research produced evidence that stimulants directly or indirectly activate brain dopamine receptors. Because nonreserpine neuroleptics such as chlorpromazine block stimulant-induced movement, these findings suggested that neuroleptics were dopamine antagonists. Most previous accounts of the development of the dopamine hypothesis of schizophrenia emphasize the first line of research and ignore the second.     

Gaining a “sense of place”: students’ affective experiences of place leading to transformative learning on international fieldwork

This paper reveals the extent to which undergraduate students demonstrate transformative learning whilst on international fieldwork in Barcelona, Spain. Groups of students create a series of discrete active learning situations that allow them and their peers to engage more fully with their locale and in turn experience a deeper understanding of “place”. Reflective field trip notebooks are used to capture the experiences of students. Results show that through the use of the affective domain (Krathwohl’s taxonomy) and applying cyclic experiential learning (Kolb) combined with critical reflection (Mezirow), students demonstrate progression and, in some cases, regression along Krathwohl’s taxonomy.     

Tourism planning and place making: place-making or placemaking?

ABSTRACT

Tourism destination planning and marketing are fundamentally place making actions intended to shape the image and imageability of a place. Place making is an innate human behavior, ranging from the organic and unplanned actions of individuals, defined here as ‘place-making,’ to planned and intentional global theming by governments and tourism authorities, defined here as ‘placemaking.’ Place-making and placemaking are ends on a continuum of options, with most places have a mix of local and global elements. These elements also range from the tangible (base in urban design) to the intangible (peoplescapes and imaginations). The tools of place making are essentially the same for both organic place-making and planned placemaking, but the intentions and outcomes can vary enormously. Tourism development, as an economic activity, almost always has a neoliberal planned placemaking agenda. Organic place-making emerges through individual agency, which if allowed to proceed, will make its imprint even in a heavily master planned tourism landscape. An understanding of place-making and placemaking gives insight into research questions on the political economy of tourism and the roles of hosts and guest in co-producing tourism places. Examining the elements of place making in a tourism landscape can more clearly identify how different worldview perspectives have contribute over time to the making of tourism places, and thereby assist in planning for the future development of destination communities.     

Gamming Chairs and Gimballed Beds: Seafaring Women on Board Nineteenth-Century Ships

During the nineteenth century, many captains’ wives from New England took up residence on the ships their husbands commanded. This article focuses on how those women at sea attempted to use material culture to domesticate their voyaging space. While writing in their journals, they referred to not only the small personal things such as books and knitting needles that they brought in their trunks, but also large items, built for and used by women, such as gamming chairs, deckhouses, parlor organs, sewing machines, and gimballed beds. Mary Brewster attempted to retreat from the ship’s officers in her small deckhouse, Annie Brassey slept in the gimballed bed, and Lucy Lord Howes disembarked in a gamming chair when captured by Confederates during the Civil War. Evidence of these artifacts found during shipwreck archaeology could be used to further what is known of the culture aboard ships on which women lived. Analysis of the material culture reveals how a captain’s wife domesticated space, altered her environment, and made a home on the ship for her family.     

The Maritime Cultural Landscape of Northern Patagonia

This article is a contribution to the study of the indigenous navigation and its boats in the region of northern Patagonia. This article also aims to contribute to the understanding of indigenous navigation practices and technologies and their origins from prehistoric times to the mid-twentieth century. It presents and discusses the concept of Westerdahl’s Maritime Cultural Landscape in relation to other landscape concepts. This model is applied to northern Patagonia in order to discuss if it is possible to speak of a true maritime culture in the region. For this purpose, archaeological, historical and ethnographic data are presented in an integrative and innovative methodology for the discipline. Finally, the Maritime Cultural Landscape model will allow the integration of aquatic and terrestrial landscapes as routes traveled by native inhabitants of northern Patagonia and southern Chile, and propose an important and diversified maritime, river and lake tradition.     

Prehispanic Dugout Canoes in Mexico: A Typology Based on a Multidisciplinary Approach

Navigation implies a deep knowledge of the environment in which it is practised as well as the development of correlated technologies and techniques. In fact, sailing in lakes, rivers, along coasts or in high seas requires specific skills. This is why watercraft reflect the specific expertise of cultures in relation to the available resources and materials. Navigation as a means of movement and boats as modes of transportation is a well-documented topic in Europe, Asia and the Pacific Ocean, whether focusing on antiquity or the present. Nonetheless, in the New World, especially in Mesoamerica where the Aztec, Tarascan and Mayan Empires flourished, indigenous maritime history has been thoroughly under-investigated. This article explores the first prehispanic dugout canoes of the region, based on a multidisciplinary approach for the Mexico and Pátzcuaro Basins, in the Late Postclassic period (AD 1325-1521). For the first time, a typology of these dugout types is proposed, with a discussion of the importance of dugout canoes as a means of transportation in Mesoamerican civilizations, where wheels and draught animals did not exist.     

Walking the Land: Aboriginal Trails,Cultural Landscapes,and Archaeological Studies for Impact Assessment

Aboriginal people have occupied northern Alberta since the end of the last ice age. For most of that time they travelled across the land by foot, producing complex networks of trails, many of which may have great antiquity. Aboriginal people also modified the landscape extensively by the use of controlled burning. Lastly, they are immersed in and “read” the land as places with multiple cultural meanings, which in turn helped shape their cultures and identities. Together, these elements indicate the existence of a series of overlapping cultural landscapes for which the cross-country trails and waterways provide the grid. This article addresses the importance of traditional trails for identifying the cultural landscapes of northeastern Alberta and points to the rapid disappearance today of knowledge about such trails. It considers how archaeological investigations done in Alberta for Impact Assessment purposes fail to consider either trails or cultural landscapes in their surveys or to consult with Aboriginal people. As a result, government Review Panels making recommendations for whether or not an industrial project should be approved are basing their findings on incomplete information about Aboriginal land uses and meanings.