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I examine the sustainability of a spatial economy consisting of an advanced region and a developing region. The advanced region aids the developing region with technological knowledge on pollution abatement. The model is based mainly on that of van den Bergh and Nijkamp (1995) but differs in that the aids are determined through an optimal control method. The numerical simulation shows that the optimal control policy is thought to be effective in the sense that almost all trajectories of the welfare index of the advanced region are single-peaked with a fairly long duration of growth, and the policy favorably affects the welfare level of the developing region.  相似文献   
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The antiquity of rheumatoid arthritis (RA) is still in dispute, due to the difficulty of conclusively differentiating peripheral polyarthritis, especially from spondyloarthropathy, in archaeological populations. In view of the importance of genetic factors in developing spondyloarthropathy and of the far lower prevalence of the disease in modern Japanese, a rarity of peripheral polyarthritis would be anticipated in the ancient Japanese population, given that RA had not been present there. One hundred and sixty adult Japanese skeletons of the late and final Jomon period (3400–2400 years bp ) were examined to find peripheral polyarthritis. There was one male skeleton with peripheral polyarthritis, showing marginal and surface erosions in the joints of the hands, feet, ankle and zygoapopheseal joints of the thoracic vertebrae. RA is suggested as the most probable cause of this pathology. This report raises the significance of further studies to consider whether more cases than anticipated exist in skeletal populations that would have been resistant to developing spondyloarthropathy. Copyright © 1999 John Wiley & Sons, Ltd.  相似文献   
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Two types of spatial heterogeneity can exist simultaneously: continuous variations across an entire space and significant changes that occur only in specific spatial units. Moreover, each of these can act across multiple spatial scales. To effectively detect both continuous and discrete spatial heterogeneity across different scales, this study proposes a novel approach that combines the random effects eigenvector spatially filtering-based spatially varying coefficient (RE-ESF-SVC) model and the generalized lasso (GL) technique. Additionally, a restricted maximum likelihood estimation (REML)-based two-step iterative algorithm is developed for parameter estimation. Simulation experiments and an empirical application using rental price data confirm the ability of the proposed model to identify multiscale continuous and discrete spatial heterogeneity.  相似文献   
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Healed bone fractures were quantitatively analyzed in an ancient Japanese population. The sample studied consisted of the skeletal remains of 160 adult individuals from the Yoshigo shell mound (ca. BP 3400‐2400), Aichi prefecture, Japan. Healed fractures were diagnosed from the presence of callus formation and/or angular deformity. Fractures were frequently seen in small bones of the hand and foot such as the metacarpals, rather than in large long bones such as the clavicle, humerus, radius, ulna, femur, tibia and fibula. Of a total of 517 intact large long bones, only four fractures (0.8%) were recognized. The prevalence and pattern of bone fractures in the Yoshigo population reflects the relative lack of stress in their life‐style. Copyright © 1999 John Wiley & Sons, Ltd.  相似文献   
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