The 4.2 ka BP climate event was a phase of severe global drought. Its evidence has been attested in many regions of the world and was reported to have played an important role in the collapse of major ancient civilizations. This article provides a comprehensive literature review using several proxies on the 4.2 ka BP climate event in Ancient Egypt. It applies a multidisciplinary approach that integrates archaeological, geoarchaeological, and bioarchaeological evidence. The conclusion is that the event had critical environmental, economic, and political impacts. It led to aridification, a decline in the Nile level and Nile-fed lakes, encroachment of aeolian desert sand into the Nile Valley, lower crop yields, and famine across ancient Egypt. Therefore, as a compound event, it played an important role in the collapse of the Old Kingdom (ca. 2181 BC), and its effect continued in the First Intermediate Period (ca. 2181–2055 BC) when Egypt witnessed political fragmentation.
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