Interdisciplinarity in the neurosciences

Abstract

The study of the human brain and of the biological nature of the mind and consciousness remains one of the greatest of all scientific challenges. Neuroscience can also lay claim to being one of the most interdisciplinary fields of scientific enquiry, and this has been true since well before the concept of interdisciplinarity was itself invented. Neuroscience draws on insights and developments in disciplines as diverse as molecular biology, electronics, biomedical engineering, statistics, psychology, biophysics, pharmacology, and linguistics. This paper examines the historical, transdisciplinary roots of modern neuroscience and reviews its contemporary interdisciplinary character, before examining two 'case studies', the emergence of functional neuroimaging as a powerful new neuroscientific tool and the ongoing dialogue between computer science and the neurosciences.     

Inclusiveness and coherency in the history of the neurosciences

The International Society for the History of the Neurosciences (ISHN) defines "neurosciences" broadly, and we want to encourage the widest possible range of scholarly approaches to our subject. However, this deliberate inclusiveness could potentially cause problems with internal coherency in our organization and in the scholarship that we are trying to create. In other words, we need to avoid the pitfalls of the internalist-externalist tension without losing the benefits of both perspectives. In fact, I think that there is a large and interesting "gray zone," where the boundary between these supposedly separate approaches is both artificial and porous. This should be one of the most rewarding intellectual domains for the study of neuroscience history, because our subject is always culturally loaded by the mind/body problem and by the assumptions that it entails. Of course, neuroscience history is also influenced by all of the other cultural and scientific aspects of the milieus in which it is conducted. Understanding neuroscience history in all of its multiple historical contexts will require the participation of a wide range of scholarly viewpoints. To keep ourselves coherent in the process, we will have to educate each other.     

Women and the history of the neurosciences

Since the closing decades of the nineteenth century, women have been contributing in a significant way to the neurosciences. This article looks at the contributions of some of the leading women pioneers in this field. It also deals with women who have written on the history of the neurosciences and the representation of women in the International Society for the History of the Neurosciences, the largest neuroscience history organization. Trends suggest that books and articles from and about women in the history of the neurosciences will increase markedly in the future.     

Neurobiographies: writing lives in the history of neurology and the neurosciences

This essay surveys the present state of biographical writing in the history of neurology and neuroscience. Individual lives play a significant role in practitioner-historians' narratives, whereas academic historians tend to be more nonindividualistic and a-biographical. Autobiographies by neurologists and neuroscientists, and particularly autobiographical collections, are problematic as an historical genre. Neurobiographies proper are published with several aims in mind: some are written as literary entertainment, others as contributions to a cultural and social history of the neurosciences. Eulogy, panegyrics and commemoration play a great role in neurobiographical writing. Some biographies, finally, are written to provide role-models for young neuroscientists, thus reviving the classical, Plutarchian biographical tradition. Finally, a recent cooperative biography of Charcot is mentioned as an example of how the biographical genre can help overcome the alleged dichotomy between the historiographies of practitioner-historians and academic historians.     

Deficiencies and challenges in the study of ancient tuberculosis DNA

We explore the standards of research and reporting needed to justify the destructive analysis of archaeological human bone for biomolecular studies of ancient tuberculosis (TB). Acceptable standards in osteological interpretation have been met in some biomolecular papers, but there are also cases where insufficient care has been taken in distinguishing between pathognomonic lesions and those that are ‘consistent with’ a diagnosis of TB. Some biomolecular studies have failed to recognize that archaeological bones might be contaminated with environmental mycobacteria whose DNA could give rise to false positives in polymerase chain reactions directed at members of the Mycobacterium tuberculosis complex. The difficulties of applying spoligotyping to ancient DNA have also been underestimated and conclusions drawn from such analyses are often weakly supported. Assumptions that mycobacterial DNA preserves better than human DNA, and that contamination with modern DNA is less of a problem, has led in some cases to a laxity in research standards with insufficient attention paid to the need to authenticate ancient DNA results. We illustrate our concerns by reference to a recent paper reporting biomolecular detection of ancient TB DNA in skeletons from the eastern Mediterranean Neolithic settlement of Atlit-Yam. We are unconvinced that the skeletal evidence presented in this paper gives sufficient indication of TB to warrant destructive analysis, and we are concerned that during the biomolecular part of the project inadequate attention was paid to the possibility that results might be due to laboratory cross-contamination or to amplification of environmental mycobacterial DNA present in the bones.     

The study of ethnicity in historical archaeology

Despite increasing interest in the archaeological study of ethnic groups few historical archaeologists have addressed the broad question of how such groups form and change. This paper presents a theory of ethnic group formation and change drawn from both anthropological and sociological research. The theory is based on the examination of the relationship of three variables: competition, ethnocentrism, and differential power. Of these variables, the differential distribution of power is given the most weight in determining changes in ethnic boundary maintenance. The development of ethnic boundaries in southern Arizona between 1854 and the early 1900s provides an example of the interrelationships among these variables. Consideration of archaeological material from this time period illustrates the necessity of archeaological data for testing the proposed theory. Further suggestions are made for the testing of the proposed theory, using historical and archaeological data.     

The original spaciality of the body itself: phenomenology and neurosciences

The phenomenological tradition stands opposed to contemporary cognitive science in this, that so far from being a mere thing in the physical world, a thing whose mind would contain some mental representation, the lived body is constituted in its sense of being for the subject by being used and actively appropriated by this self-same subject, as agent. Though not already generally acknowledged, there are important similarities between this conception and one, which emerges from the literature of brain cartography over the last twenty years, that of a functional morphogenetic neurodynamics, induced and modulated by experience in a relatively autonomous way, in relation both to the anatomic structures of the body, as well as the cytoarchitectonic frontiers of brain tissue. Taking advantage of the latter similarities, neuroscientific data can be employed to confirm the Husserlian theory of constitution against the attempts on the part of cognitive science to discredit it, and this whether we are talking about its later modification at the hands of Merleau-Ponty or the original version, which is that of a subjective (transcendental) auto-constitution of the lived body on the basis of the practico-kinaesthetic experience of .     

A history of the concept of the stimulus and the role it played in the neurosciences

The term stimulus, as it was used in science from its earliest appearance in the sixteenth century up to the beginning of the nineteenth century, shows a gradual progress in denotation from the physical object designed to produce nervous and muscular excitation to the generically conceived event or object that initiates sensory or motor activity. To this shift corresponds a shift in the understanding of sensory experience. Johannes Muller's law of specific energy of sensory nerves played a major role in the shift, and Hermann von Helmholtz gave the shift its most thorough philosophical explanation.     

历史分期的概念与历史编纂学的实践

历史编纂学中对历史的分期有自然的或技术性的分期与理论性的分期两种。中国和西方传统时代的历史学家都不注重运用历史的理论分期来编纂历史。对理论化的历史分期的热情是启蒙时代以来社会、自然和历史观念变化所激发起来的,对于中国历史学家说来是外来的。凡理论化的历史分期,其理论的根据都远远超出历史学之外,所以对于历史编纂学来说是无法从理论角度判断的,而只能从其对历史编纂学的实际产生怎样的作用来判断。任何理论模式都具有主观性。所以理论性的历史分期对于历史编纂学说来是假说、工具和方法。     

The origin of the term plasticity in the neurosciences: Ernesto Lugaro and chemical synaptic transmission

The Italian psychiatrist Ernesto Lugaro can be regarded as responsible for introducing the term plasticity into the neurosciences as early as 1906. By this term he meant that throughout life the anatomo-functional relations between neurons can change in an adaptive fashion to enable psychic maturation, learning, and even functional recovery after brain damage. Lugaro's concept of plasticity was strongly inspired by a neural hypothesis of learning and memory put forward in 1893 by his teacher Eugenio Tanzi. Tanzi postulated that practice and experience promote neuronal growth and shorten the minute spatial gaps between functionally associated neurons, thus facilitating their interactions. In addition to discovering the cerebellar cells known by his name and advancing profound speculations about the functions of the glia, Lugaro lucidly foresaw the chemical nature of synaptic transmission in the central nervous system, and was the first to propose the usage of the terms "nervous conduction" and "nervous transmission" in their currently accepted meaning.