Highland Lodge,Kilkelly, County Mayo: An Autobiographical Sketch

Fragments of neurology can be found in the oldest medical writings in antiquity. Recognizable cerebral localization is seen in Egyptian medical papyri. Most notably, the Edwin Smith papyrus describes hemiplegia after a head injury. Similar echoes can be seen in Homer, the Bible, and the pre-Hippocratic writer Alcmaeon of Croton. While Biblical writers thought that the heart was the seat of the soul, Hippocratic writers located it in the head. Alexandrian anatomists described the nerves, and Galen developed the ventricular theory of cognition whereby mental functions are classified and localized in one of the cerebral ventricles. Medieval scholars, including the early Church Fathers, modified Galenic ventricular theory so as to make it a dynamic model of cognition. Physicians in antiquity subdivided the brain into separate areas and attributed to them different functions, a phenomenon that connects them with modern neurologists.     

Camillo Golgi on the Structure of the Hippocampus

Golgi's only paper on the pes Hippocampi major was published in 1883 and then reprinted and translated a number of times. In it he stated that the fascia dentata provided the best information available to date on how nerve fibers and nerve cells are related. Based on the revolutionary silver chromate method he had introduced a decade earlier, Golgi described two sources of axons from the fascia dentata: one consisted of direct axons from the granule cells, and the other consisted of indirect axons from a diffuse neural net or reticulum that was generated from collaterals of the direct axons. The same basic arrangement was described for Ammon's horn, but neither was illustrated, and it is important to bear in mind that this work was published before the ‘neuron doctrine’ and ‘law of functional polarity’ were elaborated in the 1890s.     

Camillo Golgi on the structure of the hippocampus

Golgi's only paper on the pes Hippocampi major was published in 1883 and then reprinted and translated a number of times. In it he stated that the fascia dentata provided the best information available to date on how nerve fibers and nerve cells are related. Based on the revolutionary silver chromate method he had introduced a decade earlier, Golgi described two sources of axons from the fascia dentata: one consisted of direct axons from the granule cells, and the other coonsisted of indirect axons from a diffuse neural net or reticulum that was generated from collaterals of the direct axons. The same basic arrangement was described for Ammon's horn, but neither was illustrated, and it is important to bear in mind that this work was published before the "neuron doctrine" and "law of functional polarity" were elaborated in the 1890's.     

Vesalius on the Anatomy and Function of the Recurrent Laryngeal Nerves: Medical Illustration and Reintroduction of a Physiological Demonstration from Galen

The purpose of this article is to review the anatomical illustrations and physiological demonstrations of sixteenth-century Flemish-born anatomist and physician Andreas Vesalius concerning the recurrent laryngeal nerves. Although Vesalius was primarily an anatomist, he also used vivisection as a pedagogical device to help his students understand the function of structures within the fabric of the body that they had previously studied in anatomical detail. Vesalius’s masterwork, De humani corporis fabrica or simply the Fabrica (1543, 1555), was ostensibly an anatomy text, but Vesalius included textual and figural references to his use of vivisection to explicate the function of specific structures. Even as he began to criticize the errors in Galen’s anatomical works, Vesalius nevertheless adopted some of Galen’s classic physiological demonstrations, in particular the ligation (and subsequent release) of the recurrent laryngeal nerves of a pig to demonstrate their role in generating the pig’s squeal. Vesalius’s illustrations concerning the recurrent laryngeal nerve in the Fabrica were of two types: elegant anatomical woodcut plates—unsurpassed for their clarity, accuracy, and detail — and the distinctly inelegant historiated initial Q, depicting a throng of putti busily engaged in vivisecting a pig. Vesalius’ anatomical plates were heavily plagiarized while the historiated initials, showing the rough work of an anatomist or surgeon, were largely ignored and remain little recognized today. While Vesalius’ anatomical illustrations of the recurrent laryngeal nerves contained some errors, they were a dramatic departure from prior meager efforts at medical illustration and indeed far surpassed all contemporary published illustrations by others. Vesalius was also influential in reviving Galen’s approach to vivisection, at least for pedagogical purposes, if not really then yet as a full-fledged investigative technique.     

Vision and the Dimensions of Nerve Fibers

Vision provided the obvious source of determining the dimensions of nerve fibers when suitable achromatic microscopes were directed at neural tissue in the 1830s. The earlier microscopes of Hooke and Leeuwenhoek were unable to resolve such small structures adequately. However, it was not Hooke’s microscope that led to an estimate of the dimensions of nerve fibers, but his experiments on the limits of visual resolution; he determined that a separation of one minute of arc was the minimum that could normally be seen. Descartes had earlier speculated that the retina consisted of the ends of fibers of the optic nerve, and that their size defined the limits of what could be seen. Estimates of the diameters of nerve fibers were made on the basis of human visual acuity by Porterfield in 1738; he calculated the diameters of nerve fibers in the retina as one 7,200^th part of an inch (0.0035 mm), based on the resolution of one minute as the minimum visible. In the same year, Jurin questioned the reliability of such estimates because of variations in visual resolution with different stimuli.     

The Early Modern Sensorium: The Rosary in Seventeenth-Century Rome†

My purpose in this article is to explore the relationship between emotion and the senses in relation to the rosary and rosary confraternities in seventeenth-century Rome, with a particular emphasis on the experience of women.The rosary is well suited to an approach grounded in sensory methodology, as it is defined both as a prayer and as an object. As a object it was always kept close to the body. Praying the rosary was not only tactile (each bead was handled during prayer) but also auditory, as the prayer was said aloud. Scented rosaries were also common, adding an olfactory component to the ritual. The sense of sight was also important: as confraternities of the rosary obtained their own chapels, large altarpieces of the Madonna of the Rosary were commissioned as visual aids to prayer. Artists incorporated haptic and olfactory prompts into these images, knowing that the audience would be praying in front of them. The rosary, therefore, constituted a ‘sensorium’, defined here as the intertwining and interdependence of multiple sense modalities.The complex interaction in the rosary between prayer, bead and the scenes from the mysteries, developed gradually from older tradition of prayer beads, which is summarised here.     

Galen and the ventricular system

This paper examines the anatomy and physiology, together with the pathophysiology, of the ventricular system of the brain, as it was understood by arguably its greatest exponent in Western Antiquity, Galen. According to him, the purpose of the ventricles was to elaborate, store and distribute psychic pneuma, the motive force of Galenic neurology, throughout the nervous system. However, impressive as the delineation of the ventricular system is, the details of this distribution are not forthcoming from Galen. Finally, I discuss the ventricles as the site of intellect, a notion only tentatively advanced by Galen, but cast into dogma by his successors. For all the mistakes Galen made in anatomy and physiology, the study of the ventricular system reveals a mind not dissimilar to our own.     

Stone Tool-Making and Brain Activation: Position Emission Tomography (PET) Studies

This study introduces to archaeology a new experimental technique for examining the relationship between stone tool-making and brain function. The principal focus of this exploratory study was the development of effective methods for the identification and examination of the regions of the modern human brain recruited during the manufacture of simple (Oldowan or Mode I) stone tools. The functional brain imaging technique employed, Positron Emission Tomography (PET), examines task-related brain activity by assessing changes in regional cerebral blood flow during specific tasks. The single-subject study reported here represents a heuristic, initial exploration of this subject. Results indicate that during stone tool-making there was heavy activation of cortical and subcortical regions of the brain associated with motor and somatosensory processing. Especially interesting was the high degree of activation in areas known to be involved with complex spatial cognition requiring integration of diverse sensory inputs (e.g. vision, touch, and proprioception, or sense of body position and motion). Expansion of such higher-order association areas has been particularly important during the course of human evolution. This single-subject pilot study demonstrates the application of the PET brain imaging technique to the study of early stone technologies and suggests hypotheses to be tested in more comprehensive studies in the future.     

The search for a sixth sense: the cases for vestibular,muscle, and temperature senses

The five senses of sight, hearing, smell, taste, and touch, enumerated by Aristotle, were incremented in the early-nineteenth century by the muscle sense, multiple dimensions of touch, and a movement sense. Aristotle explicitly excluded a sixth sense, and five remains the number of senses in popular imagination. The division of touch into several sensations was entertained and rejected by Aristotle, but it was given anatomical, physiological and psychophysical support in the late-nineteenth century. A separate muscle sense was proposed in the late-eighteenth century, with experimental evidence to support it. However, before these developments, behavioral evidence of the vestibular (movement) sense was available from studies of vertigo, although it was not integrated with the anatomy and physiology of the labyrinth until the nineteenth century. The history of the search for a sixth sense is outlined, and the evidence adduced to support the divisions is assessed. Behavioral evidence generally has been accorded less weight than that from anatomy and physiology.     

The Search for a Sixth Sense: The Cases for Vestibular,Muscle, and Temperature Senses

The five senses of sight, hearing, smell, taste, and touch, enumerated by Aristotle, were incremented in the early-nineteenth century by the muscle sense, multiple dimensions of touch, and a movement sense. Aristotle explicitly excluded a sixth sense, and five remains the number of senses in popular imagination. The division of touch into several sensations was entertained and rejected by Aristotle, but it was given anatomical, physiological and psychophysical support in the late-nineteenth century. A separate muscle sense was proposed in the late-eighteenth century, with experimental evidence to support it. However, before these developments, behavioral evidence of the vestibular (movement) sense was available from studies of vertigo, although it was not integrated with the anatomy and physiology of the labyrinth until the nineteenth century. The history of the search for a sixth sense is outlined, and the evidence adduced to support the divisions is assessed. Behavioral evidence generally has been accorded less weight than that from anatomy and physiology.     

A history of the concept of the stimulus and the role it played in the neurosciences

The term stimulus, as it was used in science from its earliest appearance in the sixteenth century up to the beginning of the nineteenth century, shows a gradual progress in denotation from the physical object designed to produce nervous and muscular excitation to the generically conceived event or object that initiates sensory or motor activity. To this shift corresponds a shift in the understanding of sensory experience. Johannes Muller's law of specific energy of sensory nerves played a major role in the shift, and Hermann von Helmholtz gave the shift its most thorough philosophical explanation.     

Walter Moxon, MD, FCRP (1836-1886): the cerebro-vascular system and the syndrome of "congestion of the brain": an analysis of his 1881 Croonian Lectures

Walter Moxon, MD, FRCP lived, practiced medicine, taught and wrote in the mid- to late- nineteenth-century Victorian England, mostly at Guy's Hospital, London. He was widely informed in the "Art of Physic," writing on a range of issues from cerebral lateralization of articulate speech to angina pectoris. The present paper will trace briefly his contributions to the newly discovered asymmetry of articulate speech in the left frontal lobe (1866) and will in more detail trace and analyze his 1881 Croonian Lectures at the Royal College of Physicians on a medical shibboleth referred to as "congestion of the brain." In a series of ingenious and rhetorically creative arguments with imaginative tropes, demonstrations, evolutionary accounts of cognition and blood metabolism for human/biped cognition, and cogent citations from the medical literature of the day, Moxon skillfully instructs his medical audience against the misleading notion of cerebral "congestion" as an underlying pathology for cognitive, motor, and sensory deficits seen in the clinic. In so doing, he provides the medical community with an in-depth glimpse at the circulatory system, its flow dynamics, and how they serve to meet the cognitive, motor, and sensory demands of upright bipedal man.     

Reply to Flesher–Rick Rylance

Walter Moxon, MD, FRCP lived, practiced medicine, taught and wrote in the mid- to late- nineteenth-century Victorian England, mostly at Guy's Hospital, London. He was widely informed in the “Art of Physic,” writing on a range of issues from cerebral lateralization of articulate speech to angina pectoris. The present paper will trace briefly his contributions to the newly discovered asymmetry of articulate speech in the left frontal lobe (1866) and will in more detail trace and analyze his 1881 Croonian Lectures at the Royal College of Physicians on a medical shibboleth referred to as “congestion of the brain.” In a series of ingenious and rhetorically creative arguments with imaginative tropes, demonstrations, evolutionary accounts of cognition and blood metabolism for human/biped cognition, and cogent citations from the medical literature of the day, Moxon skillfully instructs his medical audience against the misleading notion of cerebral “congestion” as an underlying pathology for cognitive, motor, and sensory deficits seen in the clinic. In so doing, he provides the medical community with an in-depth glimpse at the circulatory system, its flow dynamics, and how they serve to meet the cognitive, motor, and sensory demands of upright bipedal man.     

A History of the Concept of the Stimulus and the Role it Played in the Neurosciences

The term stimulus, as it was used in science from its earliest appearance in the sixteenth century up to the beginning of the nineteenth century, shows a gradual progress in denotation from the physical object designed to produce nervous and muscular excitation to the generically conceived event or object that initiates sensory or motor activity. To this shift corresponds a shift in the understanding of sensory experience. Johannes Müller's law of specific energy of sensory nerves played a major role in the shift, and Hermann von Helmholtz gave the shift its most thorough philosophical explanation.     

Luis Simarro Lacabra [1851–1921]: From Golgi to Cajal Through Simarro,via Ranvier

Knowledge of cerebral structure and function in its modern form can be traced to the neurone doctrine based largely on the work of Santiago Ramón y Cajal [1852–1934] and his lifelong exploitation of the Golgi method. Cajal openly acknowledged his debt to the neuropsychiatrist Luis Simarro Lacabra [1851–1921] who introduced him to the method in 1887, and recalled that the sight of the silver-impregnated nerve cells was the turning point which led him to abandon general anatomy and concentrate on neurohistology. Simarro, who dissipated his free time in trying to improve not only the scientific but also the political world around him, was able to produce exciting Golgi preparations of the cerebral cortex after he returned from voluntary exile in Paris from 1880 to 1885. Certainly it was there that he learned the methods of experimental histology from Louis-Antoine Ranvier [1835–1922] whose laboratory exercises, in the guise of lectures, he attended assiduously.     

‘One single ivory cell’: Oscar Wilde and the Brain

This paper considers Oscar Wilde's ongoing interest in the image of a single brain cell as a souvenir of human autonomy in a world of matter. Taking a long view of Wilde's career that demonstrates the relevance to his literary work of his college interests in physiology and philosophy, this paper shows how Wilde's socialism can be explained by his uniquely aesthetic take on the brain. For many late Victorians brain science threatened both the autonomy of human action and the legitimacy of beauty because it had the potential to invalidate conscious experience, but writers whose work Wilde knew, like Ernst Haeckel, W.K. Clifford and John Tyndall, apply aesthetic vocabularies to their own discussions of cells. Their theories illuminate Wilde's representation of the cell as an aesthetic object. Wilde's art collaborates with science to reject action, as action is conventionally understood, without relinquishing beauty as his ultimate value. His discovery of beauty in matter that is beyond the pale of human experience, yet intimately and strangely constitutive of our experience, directs the senses to a new field of experience that values the molecular life the species holds in common, in which individuals and their actions matter less to the possibility of social change than does the necessity of pleasure.     

Dietrich Bonhoeffer's Repudiation of Protestant German War Theology

Dietrich Bonhoeffer was a revolutionary in two senses. Obviously, his role in the conspiracy to overthrow Hitler, when it was discovered, stamped him as a political revolutionary. Beyond that, however, Bonhoeffer was a theological revolutionary in that he repudiated and refuted the prevailing Lutheran‐Hegelian‐Rankean Geschichtsbild, i.e., image of German history, that had become paradigmatic for his class, the so‐called Bildungsbürgertum, the highly educated upper middle class. Central to this image was the idea of the Creator God as essentially a “warrior” God who realized the history of salvation via the power struggles of nation states. Bonhoeffer, in his confrontation with the Third Reich, came to the conclusion that its evil triumph had a great deal to do with the image of history that underpinned it. This article traces the evolution of the doctrine of the Power State rooted as it was in Luther's doctrine of the two kingdoms or realms, and shows how Bonhoeffer via his reflections expressed in the fragments known as Ethics, overturned that doctrine and thereby wrought an intellectual‐historical achievement of immense significance not only for Germany, but also for the modern world.     

Aspects of the history of the nerves: Bell's theory, the Bell-Magendie law and controversy, and two forgotten works by P.W. Lund and D.F. Eschricht

The French physiologist Fran?ois Magendie showed, in 1822, that the anterior roots of the spinal nerves are motor and the posterior sensory. The English anatomist Charles Bell claimed the discovery, but his claim was based on republications of papers in which the wording had been altered to be consistent with Magendie's findings. Bell also appropriated Herbert Mayo's discoveries of the functions of the fifth and seventh cranial nerves. Bell repeated his claims in a number of influential publications, supported by his brothers-in-law John and Alexander Shaw. And for a century and a half, Bell figured as the discoverer in most references to the subject. During this period, several reviewers did go back to Bell's original papers, disclosing Bell's falsifications in the republished texts. But Magendie was not definitely acknowledged as the discoverer of the function of the spinal nerve roots until Cranefield's (1974) treatise. Cranefield, as did all other reviewers, overlooked accounts from 1825 by P.W. Lund and F.D. Eschricht. They critically reviewed Bell's early publications and reached conclusions similar to those of Cranefield concerning the roles of Bell and Magendie in the discovery of the function of the spinal nerve roots.     

John Owen and John Locke: confessionalism,doctrinal minimalism,and toleration

ABSTRACT

The present article compares John Locke’s and John Owen’s approaches to toleration. Owen, a towering figure of the Puritan revolution and a Protestant scholastic whose work is still the object of significant appreciation in Reformed circles, was Locke’s dean during his time as a student in Oxford. There is a number of treatises on toleration by Owen, especially during the mid-1640s, and later again after the Restoration, in his role as a nonconforming divine. There has also been some speculation regarding the involvement of both Owen and Locke in the circle around Shaftesbury. Together with their writings against Parker and Stillingfleet, this would seem to draw Owen and Locke quite close to each other. Both authors are, however, divided in their approach to Christian doctrine: Owen represents classical confessionalism and Locke modern doctrinal minimalism. The article explores the ways in which these oppositional approaches to doctrine relate to their views of toleration.