D’Arcy Thompson’s Legacy in Contemporary Studies of Patterns and Morphology

Abstract

D’Arcy Thompson’s views on the forms of biomaterials are assessed in the light of current thinking on biomorphology in selected areas of biology. It is clear that his guiding concepts — that biological materials are structured in response to physical forces, and that the biological and abiotic realms share many common features — remain valid. Advances in the physical and biological sciences are discussed, from quantum mechanics and molecular biology to liquid crystalline materials and macroscopic forms. These reveal Thompson’s clear-sighted view of the role of physical and mathematical sciences in biology, as well as his blind-spots.     

The Electrophoretic Revolution in the 1960s: Historical Epistemology Meets the Global History of Science and Technology**

This paper uses zone electrophoresis, one of the most frequently used tools in molecular biology, to explore two ideas derived from Hans-Jörg Rheinberger's reflections on experiments. First, the constraining role played by technical objects—instrumentation and material conditions—in the production of knowledge or epistemic things. Second, the production of interconnected experimental systems by such technical objects, which results in the unexpected entanglement of research fields and experimental cultures. By the beginning of the 1960s, the inception of zone electrophoresis in laboratories around the world transformed—some say, revolutionized—the study of proteins. Even today, electrophoresis continues to open research venues and questions in biomedicine, molecular biology, human genetics, and in the field of molecular evolution. In my essay, I seek to look at the interconnected lives of zone electrophoresis and address the broader social, and even global context, in which this apparently humble technique became a salient tool in the production of biological knowledge. In so doing, I aim to take the past and present of the history and historiography of experimental systems to the future, where experiments and technologies are interrogated as they are used in different geographies and contexts, including contexts of poverty.     

Origins of molecular neurobiology: the role of the physicists

The revolution in the foundations of physics at the beginning of the twentieth century suggested to several of its most prominent workers that biology was ripe for something similar. In consequence, a number of physicists moved into biology. They were highly influential in initiating a molecular biology in the 1950s. Two decades later it seemed to several of these migrants, and those they had influenced, that the major problems in molecular biology had been solved, and that it was time to move on to what seemed to them the final problem: the nervous system, consciousness, and the age-old mind-body problem. This paper reviews this "double migration" and shows how the hopes of the first generation of physicist-biologists were both realized and dashed. No new physical principles were discovered at work in the foundations of biology or neuroscience. On the other hand, the mind-set of those trained in physics proved immensely valuable in analyzing fundamental issues in both biology and neuroscience. It has been argued that the outcome of the molecular biology of the 1950s was a change in the concept of the gene from that of "a mysterious entity into that of a real molecular object" (Watson, 1965, p.6); the gates and channels which play such crucial roles in the functioning of nervous systems have been transformed in a similar way. Studies on highly simplified systems have also opened the prospect of finding the neural correlatives of numerous behaviors and neuropathologies. This increasing understanding at the molecular level is invaluable not only in devising rational therapies but also, by defining the material substrate of consciousness, in bringing the mind-body problem into sharper focus.     

古代人骨的分子考古学研究现状与展望

本文重点讨论分子生物学在考古学研究中的应用。根据对人类学研究的回顾与展望,在以研究人类的起源和进化为首要任务的人类学研究领域,由于现代分子生物学理论和方法的应用,为人类学的发展提供了科学可信的研究方法和具发展前景的研究方向。     

In the Circulation Sphere of the Biomolecular Age: Economics and Gender Matter**

This contribution draws attention to the circulation of materialities and persons as a central feature in the constitution of experimental cultures. The protein and ribosome research at the Max Planck Society (MPG)—with a main focus on the research conducted by Brigitte Wittmann-Liebold at the Max Planck Institute for Molecular Genetics—serves as an example to highlight some of the central conditions that determined the material circulation in molecular biology: the very organizational framework of gender and economics. In doing so, this contribution argues for a historical narrative that stresses the conditions facilitating the circulation of technologies, materials, and personnel. Histories of this kind contribute to an integrated view of the scientific, technological, social, political, economic, and cultural specificities of experimental cultures.     

Spatial Competition and Bounded Rationality: Retailing at the Edge of Chaos

The spatial dimension of competition among retail outlets is well researched and typically captured with spatial interaction models. A stream of theoretical research has studied the consequences of incorporating various types of dynamics into these models. We build on this research by incorporating a behavioral decision process based on bounded rationality, and by allowing for unexpected adversity in the environment in the form of exogenous shocks. Given these characteristics—spatial competition, boundedly rational decision making, and environmental adversity—we study the long-run dynamics of a model retail industry. The model reaches a stochastic steady state which is “poised,” in the sense that a shock may—or may not—trigger a wave of innovation which sweeps the entire system. Detailed investigation of this steady state shows that it has the characteristics of a general type of organization, known as self-organized criti-cality, that has been described in both theoretical biology and statistical physics.     

From Organismic Biology as History and Philosophy to the History and Philosophy of Biology—the Work of Hans-Jörg Rheinberger in the German Context**

In this paper, I ask about the broader context of the history and philosophy of biology in the German-speaking world as the place in which Hans-Jörg Rheinberger began his work. Three German philosophical traditions—neo-Kantianism, phenomenology, and Lebensphilosophie—were interested in the developments and conceptual challenges of the life sciences in the late nineteenth and early twentieth centuries. Their reflections were taken up by life scientists under the terms theoretische Biologie (theoretical biology) and allgemeine Biologie (general biology), i. e., for theoretical and methodological reflections. They used historical and philosophical perspectives to develop vitalistic, organicist, or holistic approaches to life. In my paper, I argue that the resulting discourse did not come to an end in 1945. Increasingly detached from biological research, it formed an important context for the formation of the field of history and philosophy of biology. In Rheinberger's work, we can see the “Spalten” and “Fugen”—the continuities and discontinuities—that this tradition left there.     

Origins of Molecular Neurobiology: The Role of the Physicists

The revolution in the foundations of physics at the beginning of the twentieth century suggested to several of its most prominent workers that biology was ripe for something similar. In consequence, a number of physicists moved into biology. They were highly influential in initiating a molecular biology in the 1950s. Two decades later it seemed to several of these migrants, and those they had influenced, that the major problems in molecular biology had been solved, and that it was time to move on to what seemed to them the final problem: the nervous system, consciousness, and the age-old mind-body problem. This paper reviews this “double migration” and shows how the hopes of the first generation of physicist-biologists were both realized and dashed. No new physical principles were discovered at work in the foundations of biology or neuroscience. On the other hand, the mind-set of those trained in physics proved immensely valuable in analyzing fundamental issues in both biology and neuroscience. It has been argued that the outcome of the molecular biology of the 1950s was a change in the concept of the gene from that of “a mysterious entity into that of a real molecular object” (Watson, 1965 Watson, JD. 1965. The Molecular Biology of the Gene, New York: Benjamin.  [Google Scholar], p.6); the gates and channels which play such crucial roles in the functioning of nervous systems have been transformed in a similar way. Studies on highly simplified systems have also opened the prospect of finding the neural correlatives of numerous behaviors and neuropathologies. This increasing understanding at the molecular level is invaluable not only in devising rational therapies but also, by defining the material substrate of consciousness, in bringing the mind-body problem into sharper focus.     

Afghanistan: ‘spoilers’ in the regional security context

The ongoing international military withdrawal from Afghanistan has set the stage for energising the activities of Afghanistan's external stakeholders to re-evaluate their activities. The possible return of the Taliban in some form could compel Afghanistan's current external partners—Iran, India and Russia—to turn into limited spoilers. The absence of an international guarantor in Afghanistan from December 2014 is likely to encourage Pakistan—a greedy spoiler—to intensify its meddling as a means to reposition the Taliban—a total spoiler—at the helm of Afghan affairs. The combination of limited, greedy and total spoilers threatens to undermine security and state-building processes.     

Economic development and industrial policy in Baden — Württemberg: Small firms in a benevolent environment

Baden‐Württemberg is one of the strongest regional economies in Germany. Quite commonly, its success is explained by the technological competence of its industry, by the flexibility and ingenuity of its many small and medium‐sized firms, and by the impact of an active industrial policy. Today, however, the region has to cope with severe economic problems, and there is some evidence that these problems — at least partially — are due to its praised specific industry structure. On the other hand, there is reason to believe that the region will manage the required structural adjustment — not at least because of its well developed institutional profile. Thus, although the story of success of Baden‐Württemberg has to be revised somewhat, there are lessons to be learned with regard to industrial policy and the promotion of (regional) economic development.     

The Politics of Sources Meets the Practices of the Librarian: An Interview with Esther Chen**

[I] want to single out one phenomenon that could be called the ‘politics of sources’. It points to the extent to which the histories that both scientists and historians can write are artifacts of the available sources. The Rockefeller Foundation not only opened its archives very early on for historical work but also invested a lot in making the archives readily available for historical exploration. During the 1980s, many young historians took advantage of this opportunity. Thus, in a relatively early phase of the professional historiography of molecular biology, one could have gained the impression that the development of the new biology as a whole was a bio-politically directed enterprise of the Rockefeller Foundation sustained by the vision that social processes could ultimately be controlled by biological processes.     

Tactile Vision,Epistemic Things and Data Visualization**

Hans-Jörg Rheinberger constructed his historical epistemology of epistemic things by analyzing experimental practices in molecular biology during the 1970s and 80s. With genetic sequencing and multi-omics approaches, data has become a new resource in the life sciences, questioning the applicability of his concept of experimental system. By historicizing Rheinberger's epistemology, the paper focuses on its relatedness to Ludwik Fleck's notion of an aviso of resistance and points to a gradual shift in Rheinberger's emphasis, moving from an initial focus on writing and its differentiality to work on materials, preparations, and representations. By anchoring visualization in these material practices, Rheinberger also sheds new light on the changing conditions of experimentation in the life sciences due to big data, where visualization emphasizes patterns and correlations rather than substrates.     

Twenty‐first Century Industrial Policy in a Small Developing Country: The Challenges of Reviving Manufacturing in Rwanda

The Rwandan government — widely lauded for its political commitment to development — has refocused its efforts on reviving growth in the manufacturing sector. This article examines how pressures from different levels — international, regional and domestic — have shaped the evolving political economy of two priority sectors (apparel and cement). To achieve its goals of manufacturing sector growth, the Rwandan government aims to access foreign markets (on preferential terms) and larger regional markets while developing effective state–business relationships with locally based firms. Despite the government's political commitment to reviving its manufacturing sector, its strategy has been both shaped and impeded by shifting pressures at the international level (through Rwanda's recent suspension from the African Growth and Opportunity Act), the regional level (through competition from regional firms) and the domestic level (through over‐reliance on single firms). Within the current industrial policy literature, there is limited reflection on how developing countries are dealing with the multi‐scalar challenges of enacting industrial policy in a much‐changed global trading environment. This article contributes to the industrial policy literature by addressing this lacuna.     

Causal pathways and causal processes: Studying the evolutionary prehistory of human diversity in language,customs, and biology

An issue of continuing interest to Pacific archaeologists—the “question of Polynesian origins”—is examined (1) to illustrate a set of basic concepts (pattern, pathway, and process) helpful when talking about the origins, maintenance, and stability of similarities and differences among human populations, and (2) to document, by case example, how one particular temporal pathway of development leading to one historically specific pattern of human variability may tell us something in general, as well as something in particular, about the evolutionary processes leading to human diversity in language, customs, and biology. Contrary to the conventional assumption that the first Polynesians migrated from a homeland located somewhere in Southeast Asia, a simple biological model based on perhaps no more than three types or kinds of event sequences—i.e., causal processes—suggests how modern Polynesian speakers may be derived from an ancestral population(s) once resident in the region of the Pacific we now speak of as Melanesia.     

Charcot-Marie-Tooth disease from first description to genetic localization of mutations

Charcot-Marie-Tooth disease is a hereditary motor and sensory neuropathy first described in 1886. Our increasing knowledge of this disease correlates well with the development of methods used in neurology over the past 100 years. Although its physiopathology and treatment is still not fully understood, current developments in techniques are opening the way to future discoveries. We have divided its history into three theoretical periods: the first from 1886 to 1956, which was devoted to clinical and pathological study of the disease; the second from 1956 to 1982, which saw the development of electromyography in the investigation of neuromuscular diseases; and the last and current period based upon genetic research, using the methods of molecular biology.     

New powers in the club: the challenges of global trade governance

No good deed goes unpunished: the WTO's timely response to accommodate the new powers—Brazil, India and China—at the heart of its decision‐making has produced new inefficiencies, has heightened its proclivity to deadlock, and has exacerbated disengagement and disillusionment among all its stakeholders. Particularly in the context of a major economic crisis, a reliable international institution is necessary to ensure the continued provision of freer trade—well‐recognized as the route to recovery. With the WTO's recent record to provide these necessary public goods under doubt, where do the solutions lie? This article discusses the changing role of the new powers in the WTO, and further analyses the opportunities and challenges that these developments generate. The concluding section examines possible routes to reform. While very little can, or indeed should, be done to alter the balance of power itself, it is argued that appropriate institutional reform can help the multilateral trading system retain the advances it has made on grounds of fairness and further address the concerns of efficiency that are central to the crisis that it faces today.     

Recovery and analysis of human genetic material from mummified tissue and bone

Using sensitive techniques of molecular biology, we have been able to demonstrate the presence of genomic material of human origin in samples of mummified human tissue and bone from selected archaeological sites in Greenland. This result has far-reaching consequences for both evolutionary and archaeological studies of past human populations.     

The Role of Metallurgy in Transforming Global Forests.

Forest degradation—both past and present—has been a significant research focus of many disciplines in recent decades, and it is an area in which the multidisciplinarity and long-term perspectives of archaeological endeavour has the potential to make a particularly valuable contribution. One of the past craft activities that has long been linked to significant socio-economic change and associated accelerations in forest cover reduction and environmental decline is the intensification of early iron production—an industry reliant on the consumption of charcoal as fuel for much of its history. However, the impact of iron production on the transformation of woodlands is dependent on a suite of interrelated factors—climatic, ecological, technological and cultural—only some of which have so far been adequately scrutinised. This paper explores the theoretical context that links iron production with deforestation in academic and popular cultures, examining the role that archaeology can play in investigating this association, before reviewing recent methodological approaches that aim to interrogate the relationship between metallurgy and the environment in archaeological settings.     

Positivism as cultural policy: art and social change in the works of Comte and Saint-Simon

When discussing positivism today, it almost systematically falls into the realm of epistemological discourse. This discursive turn is primarily the by-product of the social sciences’ now-traditional approach to positivism—a turn which has been seen as largely dismissive of positivism for its antiquated and reductionist approaches to research. Without trying to make an apologetic account of positivism, this article reframes it in its broader social and historical dimensions. In particular, this article aims to illustrate how positivism—as a social and political movement—conveyed a cultural policy. In other words, this article attempts to re-engage with the intellectual legacy of positivism to resituate its significance in cultural and artistic terms in French culture, society and beyond. By drawing on the notion of implicit cultural policy, this article retraces the steps of positivism and specifically builds a case for its influence on French cultural policy in the Third Republic.