Human Genetics As a Bridging Science

Abstract

The history of the biological sciences since 1900 shows that genetic theory has to act as a unifying principle bringing together various, and sometimes quite different, fields in the analysis of common problems. This historical process can be studied especially well in the development of human genetics – a branch of science that, mainly through hybridisation, first with biochemistry, then with cytogenetics, and recently with molecular biology, developed from an outsider's hobby into one of the most challenging fields of biological and medical research. Concepts and approaches derived from genetic theory are now influencing and, in part, determining the structure of an increasing number of scientific specialities – especially in medicine – leading to important practical applications. Genetic theory and methods might also become increasingly useful for analysis of brain function in relation to behaviour.     

The Obvious in a Nutshell: Science,Medicine, Knowledge,and History

The scope and mission of the history of science have been constant objects of reflection and debate within the profession. Recently, Lorraine Daston has called for a shift of focus: from the history of science to the history of knowledge. Such a move is an attempt at broadening the field and ridding it of the contradictions deriving from its modernist myth of origin and principle of demarcation. Taking the move from a pluralistic concept of medicine, the present paper explores the actual and possible contributions that a history of knowledge can offer to the history of medicine in particular. As we will argue, the history of medicine has always been a history of knowledge, but for good reasons has always stuck to the concept of medicine as its object and problem throughout the ages, including the modern, scientific one. We argue that, in the history of medicine, the demarcation between scientific and non‐scientific represents an accident, but is not foundational as in the case of natural science. Furthermore, the history of medicine programmatically played a role in at least two academic domains (history proper and medical education), adjusting historical narratives of medical knowledge to its audience. Accordingly, we underscore that the history of both science and medicine, as traditionally defined, already provides room for almost the whole spectrum of approaches to history. Moreover, their different myths of origin can, and indeed must, be included in the reflexivity of the historical gaze. We argue that the position towards a history of science, medicine, or knowledge is not a question of narrative or theory, rather, it is a question of relevance and awareness of extant contexts.     

War on the Mind

Abstract

The new biology, a formidable triad of the disciplines of biochemistry, genetics and cell biology, has given an entirely new insight into disease processes. It is forcefully argued here that this interdisciplinary approach should be applied to tropical diseases. The detailed strategy and possible engineering of a malaria vaccine, as developed at the author's Institute, are cited as an example. But finally, society must decide if the new biology is to be used for research on the diseases of the rich or the poor peoples of this planet.     

Science,Technology and Constitutional Rights: An Interdisciplinary Forecast for the US Congress

Abstract

In honor of the bicentennial of the United States Constitution, a Congressional agency undertook an interdisciplinary analysis of the implications of new and emerging science-based technologies for constitutionally protected civil rights and liberties. Four areas of scientific research and development were identified as most likely to give rise to significantly new technological capabilities. Some of these could challenge established assumptions about individual responsibility, civil liberties, and the powers of government: information science, molecular biology, materials science, and social science, particularly as they find applications in communications and publishing, criminal justice, medicine, public health, and bioengineering. Constitutional precedents related to freedom of the press, open scientific communications, the rights of those accused or convicted of crime, due process, equal protection of laws, and individual privacy will have to be re-examined. Science is offering individuals new choices and forcing them to make new decisions, even as it brings into question some assumptions about free will and accountability.     

"Polyhybrid heterogeneous bastards": promoting medical genetics in America in the 1930s and 1940s

I examine three American researchers in the 1930s and 1940s who populate the no-man's-land of medical genetics, between the heyday of "mainline" eugenics and the medical turn in human genetics in the 1950s. In scientists' narratives, William Allan, Madge Macklin, and Laurence Snyder appear as pioneers of medical genetics and genetic education. Allan was a country doctor with an interest in heredity. Snyder, a Harvard-trained geneticist, entered medical genetics through population-genetic studies of human blood groups. Macklin came from a background in academic medicine. Allan, Snyder, and Macklin believed in a genetic approach to medicine well before genetics offered clinical benefits. Although hereditary diseases had begun to overtake infectious diseases as causes of death and illness, formal genetics offered medicine little more than a few explanatory principles. These researchers made their case by a) listing mostly hopeful potential applications of genetics to disease; b) blurring the distinction between genetics and heredity; and c) engaging in preventive genetic medicine, that is, eugenics. Examining their careers reveals some of the texture of eugenic thought in American medicine as well as the continuities between the early eugenic phase of human genetics and the professional medical genetics that today's practitioners take as the origin of their field.     

Interdisciplinary Search for Early Life Forms and for the Beginning of Life on Earth

Abstract

The evolution of life and the nature of the oldest organisms depend on the atmospheric, hydropheric and lithospheric conditions during very early terrestrial history. Specialists, working in different fields of scientific endeavour, assume that the various proposed early atmospheric, hydrospheric and lithospheric models are established; this is not the case as some of the proposed models are contradictory. The results of prebiological chemical evolution simulation experiments, actual chemical analyse of very ancient rocks and ancillary micropaleontological studies also lack agreement.

This article represents the first time a critical interdisciplinary inquiry has been attempted, based on astronomy geophysics, geochemistry, geology, atmospheric physics, oceanography, hydrology, chemistry and biology. Prebiological organic compounds have yet to be found in rocks. The oldest known rock (~3800 million years) of sedimentary origin, found in S.W. Greenland has not yet revealed microfossils and carbon compound other than methane. The (~3400 m years) Onverwacht sedimentary rocks in South Africa may or may not contain biological substances. A Transvaal stromatolite (~2300 m years) contains blue-green algal microfossils having physiologically diversified cells: these fossile algae may have modern living analogs. Artificial compounds in this small rock may well attest complex biochemistry ~2300 m years ago.     

Representing Science that Isn’t: Harvest as Science Fiction Theatre

Abstract

Engaging with the difficulty of plausibly staging scientific developments that have not yet been realized (or even those which might never occur), Manjula Padmanabhan’s 1997 play Harvest relies upon science fictional developments in two technologies, communications and medicine. Rather than merely working around them, Padmanabhan’s play makes use of the challenges inherent in staging a fictional future, calling both representation and power into question. In so doing the play exemplifies the increasing openness of science drama to science fictional ideas.     

The Responsibility of Science for the Future of Mankind

Abstract

Science and technology have brought immense benefits to man, yet through them he has become divorced from nature and he has failed to understand them. Adverse effects have been deliberately hidden, and when they became obvious, have turned science into a scapegoat. Scientists are here presented as unconcerned with the social consequences of their work, whether it affects industry or politics. The endless scientific future is now seen to have strict limits, and, the author proposes, scientists must devote themselves to the problems of mankind's future. Above all, scientists must explain their work in a language which all can understand, so that man can feel again at ease in his scientific civilization.     

Claude Bernard and an introduction to the study of experimental medicine: "physical vitalism," dialectic, and epistemology

This article explores the profound impact of the thought of Claude Bernard (1813-78) and his philosophy of experimentalism elaborated in his masterwork An Introduction to the Study of Experimental Medicine. I argue that Bernard's far-ranging theoretical impact on medicine and biology marks the end of conventional vitalism and the elusive notion of a "vital force" as a legitimate scientific concept. His understanding of medicine is as epistemologically significant in its time as Newton's contribution was to the physical sciences in the seventeenth century. This essay treats Bernard's philosophical ambitions seriously, exploring his important, even central, role in the mental world of nineteenth-century France. This includes his influence on Henri Bergson (1859-1941) and other late-nineteenth century thinkers. The subtext of Bernard's experimental epistemology is also contrasted with a key idealist philosopher of the period, the German Arthur Schopenhauer (1788-1860), and placed in the context of the larger European philosophical sphere. In contrast to much of mid-nineteenth-century philosophy, Bernard, in creating the framework for experimental medicine, argued for an experimental approach in which a priori assumptions were to be strictly constrained. Bernard's thoughts on the nature of experiment put an end to "systems" in medicine, ironically by replacing all previous medical philosophies with the all-embracing "system" of experiment. And yet, while "vital forces" fade after Bernard, a form of vitalism still flourishes. Even in Bernard's own work, in the struggle with concepts like determinism, complexity, and causality, there is a realization of the unique character of living function in a kind of "physical vitalism."     

A Review of: “Michael Hagner,Geniale Gehirne. Zur Geschichte der Elitegehirnforschung”

Charcot and Pasteur were scientific contemporaries, but their relationship has not been extensively studied. We analyzed available source documents from the Charcot Library, Bibliothèque Nationale, Institute Pasteur, and Pasteur Library. These documents demonstrate that in spite of geographical proximity, international and local recognition, Charcot and Pasteur largely pursued their careers independent of one another. Although the Paris scientific climate was one of active debate, Pasteur's and Charcot's interactions remained distanced but mutually respectful and did not descend into rivalry or contention. With different primary interests and different etiological views, side by side, they exemplified two models of French medicine at the close of the nineteenth century: medical scientist and scientific physician.     

Geography in higher education in the USSR

Abstract

Soviet geography in higher education stems from a solid tradition long pre‐dating 1917, but in Soviet times the subject's practical relevance to environmental problems has been especially emphasised. University courses are very specialised, yet in certain respects they are also extraordinarily broad by British standards. Geography graduates usually enter either teaching or scientific/ research bodies, to which they are readily suited by their training. The practical emphasis of geographical education, however, occasionally produces certain strains in the discipline.     

Midwives as expert witnesses in the 18th-century Finnish courts of justice

ABSTRACT

In this article, I will explore how legalized Finnish midwives acted as expert witnesses in court hearings before 1809, how they worded the statements they gave in court, on what grounds they decided a woman was pregnant or had given birth, and what signs they considered as indicating a miscarriage or the birth of a full-term infant. Their work as expert witnesses relied on their midwifery training as well as their learned knowledge of the anatomy of the female body and the physiology of birth. Ultimately, their knowledge was supported by contemporary guidebooks on midwifery and forensic medicine. As expert witnesses, the trained and legalized midwives of the eighteenth century can be seen as having been legally literate women, who had a duty to provide oral or written evidence to the court and other instances who demanded it. Midwives were capable of using understandable medical and legal terminology in terms of the processing of the court case in their testimony. The forensic examinations carried out by legalized midwives and the expert witness statements they gave also demonstrate the professional skills and expertise of these women.. Their testimonies also show that they were familiar with the characteristics of infanticide referred to in the Swedish medical and forensic literature.     

The Electrophoretic Revolution in the 1960s: Historical Epistemology Meets the Global History of Science and Technology**

This paper uses zone electrophoresis, one of the most frequently used tools in molecular biology, to explore two ideas derived from Hans-Jörg Rheinberger's reflections on experiments. First, the constraining role played by technical objects—instrumentation and material conditions—in the production of knowledge or epistemic things. Second, the production of interconnected experimental systems by such technical objects, which results in the unexpected entanglement of research fields and experimental cultures. By the beginning of the 1960s, the inception of zone electrophoresis in laboratories around the world transformed—some say, revolutionized—the study of proteins. Even today, electrophoresis continues to open research venues and questions in biomedicine, molecular biology, human genetics, and in the field of molecular evolution. In my essay, I seek to look at the interconnected lives of zone electrophoresis and address the broader social, and even global context, in which this apparently humble technique became a salient tool in the production of biological knowledge. In so doing, I aim to take the past and present of the history and historiography of experimental systems to the future, where experiments and technologies are interrogated as they are used in different geographies and contexts, including contexts of poverty.     

Missing or Misdiagnosed? General Paralysis of the Insane,Yaws, and Syphilis in Fiji, 1884–1940

ABSTRACT

General Paralysis of the Insane (GPI) was a deadly disease, once common in Fiji’s lunatic asylum and, by the early 20th century, thought to be caused by syphilis. The conundrum is that the majority of GPI sufferers in the asylum were Indigenous Fijians, considered to have immunity to syphilis. This immunity was probably through the prevalence of yaws amongst Indigenous Fijians. Yaws had symptoms similar to GPI and syphilis with which it was easily confused. Yaws and syphilis also invoked divergent scientific and moral discourses, with implications for how medical and scientific knowledge about the aetiology of GPI and associated moral discourses were transferred to Fiji. This paper discusses European nosology and diagnosis of GPI, yaws and syphilis, asking if GPI was misdiagnosed in Fiji, or if reports of GPI among Fijians and the effects of yaws on the nervous system are missing from tropical medicine orthodoxy.     

The dark side of human rights1

Edmund Burke argued that abstract or universal rights to food and medicine were less valuable than the aid of ‘the farmer and the physician’. His point remains unanswered. Human rights receive universal lip service, but their status and justification remain murky. From one view they are universal requirements matched by counterpart universal obligations: but if so they cannot be defined or created by international Covenants. From another view they are defined by convention and have force only when states ratify international Covenants: but if so, they are not universal. This matters particularly for rights to goods and services, such as rights to food and health care. These rights require the active collaboration of those who are to deliver needed goods and services: yet this active engagement is endangered by imposing overly complex requirements in the name of compliance with human rights. Excessive demands for compliance, and excessive emphasis on complaint, compensation and blame as remedies for non‐compliance, endanger the effective contribution of the farmer and the physician, and of others on whom the provision of needed goods and services most depends.     

Colonial ethnology and political rationality in french west Africa

This article explores the circular and mutually reinforcing relationship between professional anthropology and new technologies of administration that emerged after the First World War in French West Africa. Local administrators wrote fieldwork monographs that were formative for metropolitan science, while new native policies concerned with protecting yet improving indigenous social institutions incorporated the methods and insights of professional ethnologists. Together they created a shared field of colonial ethnology, a scientific‐administrative complex through which practical science and scientific administration constituted one another, whether deliberately or despite actors' self‐understanding. The goal is neither to dismiss anthropology as tainted by colonial history nor to accuse individual anthropologists of supporting colonial violence. Instead, this article analyzes how ethnologists' (contradictory) characterizations of African social relations and (contradictory) native policies were intrinsically related to, and did not simply influence, one another. These administrative and scientific imperatives constituted colonial humanism, a doubled and contradictory political rationality, even as they were its products. The French administration thus produced terms and data taken up by French ethnology that then shaped policies, which fueled administrative ethnographies that generated metropolitan scholarship and vice versa.     

Racial science now: histories of race and science in the age of personalized medicine

The revitalization of race-based science and medicine at the very monient in which the history of "race" in science gained such widespread critical attention forces difficult questions regarding the success of the field. This article outlines the current debate over race in contemporary biomedical research and offers a case study of the RaceSci: A History of Race in Science Web project. One of the earliest electronic resources devoted to the history of race in science, RaceSci was relaunched in early 2007 to expand its focus on the present. To date, historians are generally absent from the academic and public dialogue on the "return" of racial science. In response, RaceSci aims to better engage historians with the raced-based organization of current scientific research, particularly in genetics, drug development, and the rise of so-called "personalized" medicine.     

Structural boundaries that effect the representation of gender and disability in works of fiction from the United States and United Kingdom

Abstract

Discussions of intellectual disability are found in medical journals, published biographies, and disability research. However, outside the realm of medicine or personal reminiscence intellectual disability struggles for spaces of social, historical, cultural and imaginative representation. This article addresses these struggles for space and specifically focuses on the imagined space of narrative fiction. Being imagined spaces they should easily be able to accommodate people with disability, and yet, very few characters with intellectual disability are represented or more importantly have agency in narrative fiction. Drawing on work from feminist geographies and literary geographies this article addresses the limiting narrative structures that have been used against fictional characters who have a disability and ways authors may move beyond these limitations. Reconciling feminist geographies and literary geographies allows new critical spatial knowledge around disability to emerge. It is not enough to write characters with disabilities into narrative fiction if the structures surrounding them remain limiting and prejudiced. This article discusses the three main limiting structures in narrative fiction: character representation, narrative voice and genre. Looking at narrative fiction through feminist and literary geographies reveals how these limiting structures function as power hierarchies, and importantly, shows how these imposed structures can be subverted and changed.