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1.
    
Just when molecular biology is arguably delivering on some of its long-promised medical applications—think mRNA vaccines, monoclonal antibody drugs, PCR testing, and gene therapies—the history of molecular biology has lost much of its shine. What not too long ago seemed like a burgeoning field of research with endless possibilities, is now often reduced to the “central dogma” that saw its apotheosis in the effort to sequence the human genome but has since unraveled. The essay will discuss several possible answers to this apparent paradox.  相似文献   

2.
In this paper, I ask about the broader context of the history and philosophy of biology in the German-speaking world as the place in which Hans-Jörg Rheinberger began his work. Three German philosophical traditions—neo-Kantianism, phenomenology, and Lebensphilosophie—were interested in the developments and conceptual challenges of the life sciences in the late nineteenth and early twentieth centuries. Their reflections were taken up by life scientists under the terms theoretische Biologie (theoretical biology) and allgemeine Biologie (general biology), i. e., for theoretical and methodological reflections. They used historical and philosophical perspectives to develop vitalistic, organicist, or holistic approaches to life. In my paper, I argue that the resulting discourse did not come to an end in 1945. Increasingly detached from biological research, it formed an important context for the formation of the field of history and philosophy of biology. In Rheinberger's work, we can see the “Spalten” and “Fugen”—the continuities and discontinuities—that this tradition left there.  相似文献   

3.
When Hans-Jörg Rheinberger proposed the concept of epistemic things, he drew inspiration from the art historian George Kubler, who had considered the aesthetic object as resulting from problem-solving processes in The Shape of Time (1962). Kubler also demonstrated that a sequence of objects could retrace the progress that led to a solution that was afterwards accepted as the most classical. Parallel to Kubler, Rheinberger demonstrates how temporally extended activities of experimentation are condensed in the object, revealing the moments of innovation that lead to it. In the history of science as well as in art history, various trajectories can thus be grasped in the materially given. Rheinberger conceives of an object as a network of heterogeneous time strings. However, these are manifold: they cannot be thought of as making up a homogeneous temporality encompassing all the others as a temporal container and synchronizing them within it. Since the discovery of the Anthropocene, we no longer separate natural from cultural time, and no hegemonic historical narrative can be taken as unifying all the others. Historical epistemology as proposed by Rheinberger will be read as a contribution to constructing new models of natural as well as of cultural time.  相似文献   

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