The role of imagination in modern medicine

In Renaissance and early modern times, the concept of imagination (Latin imaginatio) was essential for the (natural) philosophical explanation of magic processes, especially in the anthropology of Paracelsus. He assumed that imagination was a natural vital power including cosmic, mental, phychical, and physical dimensions. The Paracelsians criticized traditional humor pathology ignoring their theory of' 'natural magic'. On the other hand, they were criticized by their adversaries as charlatans practicing 'black magic'. About 1800, in between enlightenment and romanticism, the healing concept of, animal magnetism' (Mesmerism) evoked an analogous debate, whether, magnetic' phenomena originated from a real (physical) power (so-called, fluidum') or were just due to fantasy or imagination (German Einbildungskraft). At the end of the 19th century, the French internist Hippolyte Bernheim created-against the background of medical hypnosis (hypnotism') as a consequence of Mesmerism - his theory of suggestion and autosuggestion: a new paradigm of psychological respectively psychosomatic medicine, which became the basis for the concept of, placebo' in modern biomedicine. From now on, all the effects of, alternative medicine' could easily be explained by the, placebo-effect', more or less founded - at least unconsciously - on fraud.     

The future of molecular medicine

Abstract

Humanities computing is an ‘interdiscipline’ concerned with the application of computing to the arts and letters. Although it has been practised since the late 1940s, it has only recently begun to gain institutional recognition and a measure of self-awareness. In this contribution to the vigorous debate among practitioners, I argue for a common methodological ground shared by computer using scholars and students across the disciplines of the humanities. In large part because of the commons, these individuals tend to come together physically in laboratory settings as well as virtually online, pursuing traditional research goals by the means they now share, or collaborating on numerous larger projects that computing has enabled. A useful model of their collaboration is Peter Galison's ‘trading zone’, an anthropological–linguistic metaphor he uses to describe interchange among researchers and technicians of the Manhattan Project. Humanities computing functions like a merchant trader in a Galisonian trading zone: it sees to a similar interchange of tools and techniques among the departmentalised cultures with which it deals, and for itself studies the effects and consequences. It thus exemplifies a true interdisciplinarity. Sufficient work has now been done for us to begin to map out a research agenda for humanitites computing as an interdiscipline, and this will help to identify the essential habits of mind and skills our colleagues and students must have to refurbish the humanities in the twenty-first century. Computing presents the humanities with the need and opportunity to reconceptualise and rebuild our inherited scholarly forms, which are as historically contingent as any human artefact. Rethinking how we do what we do in turn requires what Clifford Geertz has called ‘intellectual weed control’. A central project of humanities computing is to help in the construction of a worldwide digital library of resources and tools. Its role within this project is, I argue, primarily to articulate the powers of imagination that computing in the humanities demands of us.     

Lung cancer, chronic disease epidemiology, and medicine, 1948-1964

Beginning in the early 1950s, a series of epidemiological, biochemical, pathological, and animal studies demonstrated a link between cigarette smoking and lung cancer. A number of reputable scientists challenged these findings, but for a variety of reasons, including the behavior of the tobacco industry, historians have assumed that these objections were insubstantial and disingenuous. Viewing these objections in scientific and medical perspective, however, suggests that there was a legitimate and reasonable scientific controversy over cigarette smoking and lung cancer in the 1950s and early 1960s. That controversy had important consequences. A new chronic disease epidemiology emerged, transforming the role and importance of epidemiology to medical research. This new epidemiology supplemented Koch's postulates, establishing a statistical method that allowed for linking environmental factors to the etiology of chronic diseases. The 1964 report to the surgeon general, Smoking and Health, represented the denouement and codification of these developments. This reexamination of the scientific controversy over smoking in the 1950s and early 1960s provides an important context for understanding the subsequent public relations battles between the tobacco industry and public health after 1964.